Gene Information gene info

GENE:UNC5B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UNC5B
FullNmae unc-5 netrin receptor B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12568
EnsembleID ENSG00000107731
Uniprot Q8IZJ1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UNC5B ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UNC5B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UNC5B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
UNC5B GO:0001525,GO:0005042,GO:0005515,GO:0005886,GO:0006915,GO:0033564,GO:0038007,GO:0043524,GO:0045121,GO:0051897,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UNC5B hsa:219699 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DAPK1 UNC5B 12598906 17703233 18582460 19543238 20173780 20495383 21172648 21172653 22920895 26192618 interaction type N/A ACSN
NTN1 UNC5B 12598906 17703233 18582460 19543238 20173780 20495383 21172653 22920895 26192618 interaction type N/A ACSN
UNC5B PPP2CB 12598906 17703233 18582460 19543238 20495383 21172648 21172653 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR UNC5B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 UNC5B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 UNC5B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 UNC5B 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 UNC5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 UNC5B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A7F58 UNC5B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 UNC5B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000105D19 UNC5B 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000279B6F UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DA458 UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 UNC5B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 UNC5B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 UNC5B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 UNC5B 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000018C928 UNC5B 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 UNC5B 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000170CF4 UNC5B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B UNC5B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 UNC5B 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005ACA7C UNC5B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001D4A78 UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000913AC UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001F14FE UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075B538 UNC5B 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NEO1 UNC5B 25361965 interaction type N/A PTMCode2
UNC5B NEO1 25361965 interaction type N/A PTMCode2
NTN1 UNC5B 25361965 interaction type N/A PTMCode2
UNC5B NTN1 25361965 interaction type N/A PTMCode2
UNC5B NTN4 25361965 interaction type N/A PTMCode2
NTN4 UNC5B 25361965 interaction type N/A PTMCode2
UNC5B DAPK1 25361965 interaction type N/A PTMCode2
DAPK1 UNC5B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TUBG1 UNC5B 25348397 N/A physical interaction ComPPI
NTRK1 UNC5B 25348397 N/A physical interaction ComPPI
CANX UNC5B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PPP2CA UNC5B 25348397 N/A physical interaction ComPPI
NTN1 UNC5B 18719102 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B UNC5B 25348397 N/A physical interaction ComPPI
TGOLN2 UNC5B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BET1 UNC5B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UNC5B DAPK1 14525934 15729359 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UNC5B CIP2A 25348397 N/A physical interaction ComPPI
UNC5B TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
UNC5B TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
UNC5B LRRIQ1 25348397 N/A physical interaction ComPPI
UNC5B NEO1 18719102 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UNC5B LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UNC5B PPP2R3B 15729359 27898060 stimulant N/A OmniPath
UNC5B DAPK1 15729359 21172653 27898060 inhibition,stimulant N/A OmniPath
NTN1 UNC5B 27898060 9126742 stimulant N/A OmniPath

Visualization