GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
UNC5B
FullNmae
unc-5 netrin receptor B
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:12568
EnsembleID
ENSG00000107731
Uniprot
Q8IZJ1
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
UNC5B
ferroptosis
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
UNC5B
apoptosis
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
UNC5B
apoptosis
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
Go Annotation:
GeneSymbol
Go id
UNC5B
GO:0001525,GO:0005042,GO:0005515,GO:0005886,GO:0006915,GO:0033564,GO:0038007,GO:0043524,GO:0045121,GO:0051897,GO:2001240
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
UNC5B
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
GATA2
UNC5B
18971253
19941826
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
UNC5B
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
PRDM14
UNC5B
18971253
20953172
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
SMARCA4
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXP1
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TRIM28
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
ZNF263
UNC5B
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TP53
UNC5B
N/A
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00001A7F58
UNC5B
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS00000AA464
UNC5B
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS0000105D19
UNC5B
24374217
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001A6D0C
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00003E5ECC
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000014F13C
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000279B6F
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001DA458
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000015A0D9
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000235862
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000383DF4
UNC5B
20371350
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000334286
UNC5B
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001CE046
UNC5B
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000236310
UNC5B
23313552
23824327
25416803
27418678
mrna cleavage,inhibition
clip
TarBase
URS000018C928
UNC5B
23313552
23824327
25416803
27418678
mrna cleavage,inhibition
clip
TarBase
URS000076B539
UNC5B
23313552
23824327
25416803
27418678
mrna cleavage,inhibition
clip
TarBase
URS0000170CF4
UNC5B
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000003575B
UNC5B
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000085F64
UNC5B
23313552
23824327
25416803
27418678
mrna cleavage,inhibition
clip
TarBase
URS00005ACA7C
UNC5B
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000568FF8
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS00001D4A78
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS0000160683
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS00005F9738
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS00000913AC
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS00001F14FE
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
URS000075B538
UNC5B
25416803
26701625
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
NEO1
UNC5B
25361965
interaction type
N/A
PTMCode2
UNC5B
NEO1
25361965
interaction type
N/A
PTMCode2
NTN1
UNC5B
25361965
interaction type
N/A
PTMCode2
UNC5B
NTN1
25361965
interaction type
N/A
PTMCode2
UNC5B
NTN4
25361965
interaction type
N/A
PTMCode2
NTN4
UNC5B
25361965
interaction type
N/A
PTMCode2
UNC5B
DAPK1
25361965
interaction type
N/A
PTMCode2
DAPK1
UNC5B
25361965
interaction type
N/A
PTMCode2
Source
Target
Pmid
Interactiontype
Methods
Database
TUBG1
UNC5B
25348397
N/A
physical interaction
ComPPI
NTRK1
UNC5B
25348397
N/A
physical interaction
ComPPI
CANX
UNC5B
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
PPP2CA
UNC5B
25348397
N/A
physical interaction
ComPPI
NTN1
UNC5B
18719102
24234451
25348397
physical association
anti bait coimmunoprecipitation,physical interaction
ComPPI,IntAct
PPP2R1B
UNC5B
25348397
N/A
physical interaction
ComPPI
TGOLN2
UNC5B
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
BET1
UNC5B
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
UNC5B
DAPK1
14525934
15729359
25348397
N/A
experimental interaction detection,physical interaction
ComPPI,HPRD
UNC5B
CIP2A
25348397
N/A
physical interaction
ComPPI
UNC5B
TMEM17
24234451
25348397
26638075
association
physical interaction,proximity-dependent biotin identification
ComPPI,IntAct
UNC5B
TMEM216
24234451
25348397
26638075
association
physical interaction,proximity-dependent biotin identification
ComPPI,IntAct
UNC5B
LRRIQ1
25348397
N/A
physical interaction
ComPPI
UNC5B
NEO1
18719102
24234451
25348397
physical association
anti bait coimmunoprecipitation,physical interaction
ComPPI,IntAct
UNC5B
LAMP1
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
UNC5B
PPP2R3B
15729359
27898060
stimulant
N/A
OmniPath
UNC5B
DAPK1
15729359
21172653
27898060
inhibition,stimulant
N/A
OmniPath
NTN1
UNC5B
27898060
9126742
stimulant
N/A
OmniPath
Visualization