GENE：USP28
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | USP28 |
| FullNmae | ubiquitin specific peptidase 28 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12625 |
| EnsembleID | ENSG00000048028 |
| Uniprot | Q96RU2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| USP28 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| USP28 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| USP28 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| USP28 | GO:0000077,GO:0000077,GO:0004843,GO:0004843,GO:0004843,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0008283,GO:0010212,GO:0016579,GO:0016579,GO:0016604,GO:0031647,GO:0031647,GO:0032991,GO:0034644,GO:0042771,GO:0071947,GO:0101005 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | USP28 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | USP28 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | USP28 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | USP28 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000FC8EB | USP28 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | USP28 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000170CF4 | USP28 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000B989F | USP28 | 21572407 23389829 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,quantitative reverse transcription pcr,clip | TarBase |
| URS0000007FBA | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | USP28 | 21572407 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | USP28 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E3523 | USP28 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | USP28 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | USP28 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | USP28 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | USP28 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | USP28 | 25416803 27988424 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000157F5 | USP28 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | USP28 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | USP28 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077AED | USP28 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATM | USP28 | 22135298 | phosphorylation | N/A | PhosphoSite |
| USP28 | CLSPN | 25361965 | interaction type | N/A | PTMCode2 |
| CLSPN | USP28 | 25361965 | interaction type | N/A | PTMCode2 |
| USP28 | TP53BP1 | 25361965 | interaction type | N/A | PTMCode2 |
| TP53BP1 | USP28 | 25361965 | interaction type | N/A | PTMCode2 |
| USP28 | MDC1 | 25361965 | interaction type | N/A | PTMCode2 |
| MDC1 | USP28 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| USP20 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| JOSD1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| NSMCE2 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | USP28 | 14525934 16901786 19615732 24234451 25348397 29656893 | association,physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification | ComPPI,HPRD,IntAct |
| FBXW7 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| PRKD1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP7 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| CIT | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| UBC | USP28 | 22626734 25348397 25359778 26268556 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PLA2G2A | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USO1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | USP28 | 24234451 25348397 25593058 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MYC | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP4 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| SUMO2 | USP28 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TRIM63 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP8 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| RCHY1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| MDC1 | USP28 | 14525934 16901786 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| UCHL1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP33 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| PJA1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| STAM | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| MTNR1A | USP28 | 24234451 25348397 26514267 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ELAVL1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| TWF1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| KDM1A | USP28 | 24075993 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| STAMBP | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| BAP1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| CLSPN | USP28 | 14525934 16901786 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| SENP2 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| UCHL3 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM55 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| UCHL5 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP21 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| OTUB2 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP5 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| AP5Z1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| KLHL2 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | AQR | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| USP28 | USP25 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| USP28 | RFFL | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | USP51 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | OTUB1 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | ATXN3L | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | USP15 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | ESPL1 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | SENP8 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | USP14 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | ZC3H4 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | ZCCHC8 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | PFAS | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | MAP3K1 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | FOXK1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| USP28 | ZNF304 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | MRPS7 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | SPPL2B | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | TP53 | 22653443 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ST6GAL1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| COMTD1 | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| USP28 | MYC | 17558397 17873522 19680264 23389829 25716680 27898060 | inhibition,stimulant | N/A | OmniPath |
| USP28 | FBXW7 | 20399964 27898060 | inhibition | N/A | OmniPath |
| USP28 | SKP1 | 17873522 27898060 | inhibition | N/A | OmniPath |
| ATM | USP28 | 16901786 27898060 | stimulant | N/A | OmniPath |
| USP28 | CLSPN | 16901786 19680264 27898060 | inhibition,stimulant | N/A | OmniPath |