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GENE：VDAC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VDAC2
FullNmae voltage dependent anion channel 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12672
EnsembleID ENSG00000165637
Uniprot P45880

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VDAC2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VDAC2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
VDAC2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VDAC2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
VDAC2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VDAC2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
VDAC2 GO:0000166,GO:0001669,GO:0005515,GO:0005634,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0006820,GO:0007339,GO:0008308,GO:0008308,GO:0015288,GO:0015485,GO:0016020,GO:0031210,GO:0031966,GO:0032272,GO:0042645,GO:0046930,GO:0097001,GO:0097225,GO:0097345,GO:0098656,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VDAC2 hsa:7417 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04216 Ferroptosis - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04217 Necroptosis - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04218 Cellular senescence - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05010 Alzheimer disease - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05012 Parkinson disease - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05016 Huntington disease - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05020 Prion disease - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
VDAC2 hsa:7417 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BAK1 VDAC2 12881569 19706873 22039431 23430059 23850759 26192618 association N/A ACSN
BCL2L1 VDAC2 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
VDAC2 BCL2L1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
VDAC2 BAK1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOS3 VDAC2 22842492 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDK2 VDAC2 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR VDAC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 VDAC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 VDAC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 VDAC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 VDAC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC VDAC2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 VDAC2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00003CF1AD VDAC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C VDAC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002FC5B0 VDAC2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 VDAC2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000045B99E VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D VDAC2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004407DC VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000022B729 VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AD450 VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000247AC6 VDAC2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFB9 VDAC2 25348397 N/A physical interaction ComPPI
ATP5PO VDAC2 25348397 N/A physical interaction ComPPI
RPN1 VDAC2 25348397 N/A physical interaction ComPPI
STX12 VDAC2 25348397 N/A physical interaction ComPPI
ATP5F1B VDAC2 25348397 N/A physical interaction ComPPI
TRAF6 VDAC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ACTB VDAC2 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
CYCS VDAC2 25348397 27898060 9615439 N/A in vivo ComPPI,OmniPath
JAGN1 VDAC2 25348397 N/A physical interaction ComPPI
SLC38A1 VDAC2 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
CD4 VDAC2 25348397 N/A physical interaction ComPPI
SND1 VDAC2 25348397 N/A physical interaction ComPPI
JUN VDAC2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2L3 VDAC2 25348397 N/A physical interaction ComPPI
U2AF2 VDAC2 25348397 N/A physical interaction ComPPI
VAPA VDAC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB7A VDAC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBA52 VDAC2 25348397 N/A physical interaction ComPPI
NTRK1 VDAC2 25348397 N/A physical interaction ComPPI
PHKG2 VDAC2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CANX VDAC2 22045338 24234451 25348397 29568061 colocalization,association cosedimentation through density gradient,pull down ComPPI,IntAct
RPS3A VDAC2 25348397 N/A in vitro ComPPI
SSBP1 VDAC2 25348397 N/A physical interaction ComPPI
PHB VDAC2 25348397 N/A physical interaction ComPPI
HNRNPU VDAC2 25348397 N/A physical interaction ComPPI
CFTR VDAC2 25348397 N/A physical interaction ComPPI
MAPK6 VDAC2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC1 VDAC2 24234451 25348397 29128334 association,physical association cross-linking study,physical interaction,blue native page ComPPI,IntAct
PDHA1 VDAC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB1A VDAC2 25348397 N/A physical interaction ComPPI
ECT2 VDAC2 25348397 N/A physical interaction ComPPI
TRAP1 VDAC2 25348397 N/A physical interaction ComPPI
CLTC VDAC2 25348397 N/A physical interaction ComPPI
ABCE1 VDAC2 25348397 N/A physical interaction ComPPI
VDAC2 BAK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
VDAC2 HK1 25348397 27898060 8420959 N/A in vitro ComPPI,OmniPath
VDAC2 SERINC3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 SNCA 18614564 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
VDAC2 MME 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 HDAC5 25348397 N/A physical interaction ComPPI
VDAC2 CDK2 25348397 N/A physical interaction ComPPI
VDAC2 PRKN 25348397 N/A physical interaction ComPPI
VDAC2 APP 25348397 N/A physical interaction ComPPI
VDAC2 RPSA 25348397 N/A physical interaction ComPPI
VDAC2 VDAC3 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 ATP6V1H 25348397 N/A physical interaction ComPPI
VDAC2 SFXN3 25348397 N/A physical interaction ComPPI
VDAC2 DDOST 25348397 N/A physical interaction ComPPI
VDAC2 FLOT2 25348397 N/A physical interaction ComPPI
VDAC2 MPV17 25348397 N/A physical interaction ComPPI
VDAC2 SCP2 25348397 N/A physical interaction ComPPI
VDAC2 ZFR 25348397 N/A physical interaction ComPPI
VDAC2 SUGP1 25348397 N/A physical interaction ComPPI
VDAC2 ELAVL1 25348397 N/A physical interaction ComPPI
VDAC2 FAM162A 15082785 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
VDAC2 THOC6 25348397 N/A physical interaction ComPPI
VDAC2 SEPTIN11 25348397 N/A physical interaction ComPPI
VDAC2 ATP6V1F 25348397 N/A physical interaction ComPPI
VDAC2 UTP14A 25348397 N/A physical interaction ComPPI
VDAC2 ACAA2 25348397 N/A physical interaction ComPPI
VDAC2 MDC1 25348397 N/A physical interaction ComPPI
VDAC2 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 FN1 25348397 N/A physical interaction ComPPI
VDAC2 ITGA4 25348397 N/A physical interaction ComPPI
VDAC2 ADRB2 25348397 N/A physical interaction ComPPI
VDAC2 FBXO6 25348397 N/A physical interaction ComPPI
VDAC2 FOXRED2 25348397 N/A physical interaction ComPPI
VDAC2 EMC1 25348397 N/A physical interaction ComPPI
VDAC2 PPT1 25348397 N/A physical interaction ComPPI
VDAC2 ARF5 25348397 N/A physical interaction ComPPI
VDAC2 ATP5F1A 25348397 N/A physical interaction ComPPI
VDAC2 ATP5F1D 25348397 N/A physical interaction ComPPI
VDAC2 ATP5ME 25348397 N/A physical interaction ComPPI
VDAC2 ATP6V0D1 25348397 N/A physical interaction ComPPI
VDAC2 BCAP31 25348397 N/A physical interaction ComPPI
VDAC2 CISD1 25348397 N/A physical interaction ComPPI
VDAC2 CISD2 25348397 N/A physical interaction ComPPI
VDAC2 GPX4 25348397 N/A physical interaction ComPPI
VDAC2 MAGT1 25348397 N/A physical interaction ComPPI
VDAC2 NDUFA12 25348397 N/A physical interaction ComPPI
VDAC2 NDUFA8 25348397 N/A physical interaction ComPPI
VDAC2 NDUFA9 25348397 N/A physical interaction ComPPI
VDAC2 NDUFV1 25348397 N/A physical interaction ComPPI
VDAC2 PHB2 25348397 N/A physical interaction ComPPI
VDAC2 RER1 25348397 N/A physical interaction ComPPI
VDAC2 SGPL1 25348397 N/A physical interaction ComPPI
VDAC2 SLC25A5 25348397 N/A physical interaction ComPPI
VDAC2 SSR3 25348397 N/A physical interaction ComPPI
VDAC2 STX7 25348397 N/A physical interaction ComPPI
VDAC2 TOMM40 25348397 N/A physical interaction ComPPI
VDAC2 TSPO 25348397 N/A physical interaction ComPPI
VDAC2 UQCRQ 25348397 N/A physical interaction ComPPI
VDAC2 ABCC1 25348397 N/A physical interaction ComPPI
VDAC2 ABCC3 25348397 N/A physical interaction ComPPI
VDAC2 ACADM 25348397 N/A physical interaction ComPPI
VDAC2 ATP1A1 25348397 N/A physical interaction ComPPI
VDAC2 ATP1A2 25348397 N/A physical interaction ComPPI
VDAC2 ATP1A3 25348397 N/A physical interaction ComPPI
VDAC2 ATP1B3 25348397 N/A physical interaction ComPPI
VDAC2 ATP5F1C 25348397 N/A physical interaction ComPPI
VDAC2 ATP5PB 25348397 N/A physical interaction ComPPI
VDAC2 ATP6V1A 25348397 N/A physical interaction ComPPI
VDAC2 CYC1 25348397 N/A physical interaction ComPPI
VDAC2 IMMT 25348397 N/A physical interaction ComPPI
VDAC2 MTCH1 25348397 N/A physical interaction ComPPI
VDAC2 MTCH2 25348397 N/A physical interaction ComPPI
VDAC2 MT-CO2 25348397 N/A physical interaction ComPPI
VDAC2 NDUFS4 25348397 N/A physical interaction ComPPI
VDAC2 SLC25A11 25348397 N/A physical interaction ComPPI
VDAC2 TECR 25348397 N/A physical interaction ComPPI
VDAC2 TMX1 25348397 N/A physical interaction ComPPI
VDAC2 UQCRC2 25348397 N/A physical interaction ComPPI
VDAC2 MED23 25348397 N/A physical interaction ComPPI
VDAC2 HERC2 25348397 N/A physical interaction ComPPI
VDAC2 HERC2P3 25348397 N/A physical interaction ComPPI
VDAC2 RAB5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 MTX2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 TRIM33 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 FAF2 25348397 N/A physical interaction ComPPI
VDAC2 DENR 25348397 N/A physical interaction ComPPI
VDAC2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 DHRS2 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
VDAC2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC2 ACAD9 23260140 24234451 25348397 association blue native page ComPPI,IntAct
VDAC2 HTT 17500595 24234451 25348397 association pull down ComPPI,IntAct
VDAC2 SLC38A9 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC2 DUX4L9 24234451 25348397 26816005 physical association two hybrid ComPPI,IntAct
VDAC2 DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
VDAC2 TUBA1A 24234451 25348397 27291054 association pull down ComPPI,IntAct
VDAC2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC2 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VDAC2 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VDAC2 TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VDAC2 AIFM1 24234451 25348397 29568061 association pull down ComPPI,IntAct
VDAC2 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
NEDD4L VDAC2 25348397 N/A physical interaction ComPPI
ATF2 VDAC2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 VDAC2 25348397 N/A physical interaction ComPPI
ILVBL VDAC2 25348397 N/A physical interaction ComPPI
MGST3 VDAC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MKI67 VDAC2 24234451 26949251 association anti tag coimmunoprecipitation IntAct
METTL14 VDAC2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
VDAC2 LRRC42 24234451 30021884 physical association cross-linking study IntAct
VDAC2 LRP2 24234451 30021884 physical association cross-linking study IntAct
VDAC2 CHCHD2P9 24234451 30021884 physical association cross-linking study IntAct
RPS19 VDAC2 24234451 30021884 physical association cross-linking study IntAct
VDAC2 DDX21 24234451 30021884 physical association cross-linking study IntAct
VDAC2 PZP 24234451 30021884 physical association cross-linking study IntAct
AKAP9 VDAC2 24234451 30021884 physical association cross-linking study IntAct
HNRNPCL2 VDAC2 24234451 30021884 physical association cross-linking study IntAct
RALY VDAC2 24234451 30021884 physical association cross-linking study IntAct
HNRNPC VDAC2 24234451 30021884 physical association cross-linking study IntAct
VDAC2 AHNAK 24234451 30021884 physical association cross-linking study IntAct
VDAC2 DRD2 24234451 30021884 physical association cross-linking study IntAct
BCL2L1 VDAC2 22705850 27898060 N/A N/A OmniPath
VDAC2 BAK1 12881569 17353931 22705850 27898060 inhibition,stimulant N/A OmniPath

Visualization










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