GENE：WNT4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT4 |
| FullNmae | Wnt family member 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12783 |
| EnsembleID | ENSG00000162552 |
| Uniprot | P56705 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT4 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WNT4 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT4 | GO:0001658,GO:0001822,GO:0001837,GO:0001838,GO:0001889,GO:0003714,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0005886,GO:0008543,GO:0008584,GO:0008584,GO:0008585,GO:0009267,GO:0009986,GO:0010629,GO:0010894,GO:0022407,GO:0030182,GO:0030237,GO:0030325,GO:0030336,GO:0030501,GO:0030666,GO:0031012,GO:0032349,GO:0032967,GO:0033080,GO:0040037,GO:0042445,GO:0045165,GO:0045596,GO:0045669,GO:0045836,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0048018,GO:0048599,GO:0051145,GO:0051496,GO:0051894,GO:0060008,GO:0060070,GO:0060070,GO:0060126,GO:0060129,GO:0060231,GO:0060748,GO:0061045,GO:0061180,GO:0061184,GO:0061205,GO:0061369,GO:0070062,GO:0071560,GO:0072033,GO:0072034,GO:0072162,GO:0072174,GO:0072273,GO:0097190,GO:0140013,GO:1904238,GO:2000019,GO:2000066,GO:2000180,GO:2000225,GO:2001234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT4 | hsa:54361 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT4 | hsa:54361 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SOX11 | WNT4 | 23180781 24681958 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SFRP1 | WNT4 | 11287180 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| SFRP2 | WNT4 | 11287180 18988627 23331499 9853965 | interaction type | N/A | SignaLink,SignaLink |
| WNT4 | FZ | 12205098 23331499 | stimulation | N/A | SignaLink,SignaLink |
| WNT4 | FZ2 | 12205098 23331499 | stimulation | N/A | SignaLink,SignaLink |
| WNT4 | FZ4 | 12205098 23331499 | stimulation | N/A | SignaLink,SignaLink |
| WNT4 | FZD3 | 14671310 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EGR1 | WNT4 | 18281035 18971253 21436631 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| ETS1 | WNT4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | WNT4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | WNT4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | WNT4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PAX9 | WNT4 | 25270402 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | WNT4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX3 | WNT4 | 22171134 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF7L2 | WNT4 | 21436631 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF4 | WNT4 | 21436631 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272A3D | WNT4 | 21436257 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | WNT4 | 21436257 25416803 26484393 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001CF056 | WNT4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | WNT4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | WNT4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | WNT4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000011166D | WNT4 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | WNT4 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047944F | WNT4 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048F59D | WNT4 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCDA3 | WNT4 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | WNT4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | WNT4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E7139 | WNT4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | WNT4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | WNT4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SFRP2 | WNT4 | 25361965 | interaction type | N/A | PTMCode2 |
| WNT4 | SFRP2 | 25361965 | interaction type | N/A | PTMCode2 |
| WNT4 | PORCN | 25361965 | interaction type | N/A | PTMCode2 |
| PORCN | WNT4 | 25361965 | interaction type | N/A | PTMCode2 |
| WNT4 | FZD6 | 25361965 | interaction type | N/A | PTMCode2 |
| FZD6 | WNT4 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RNF40 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| SFRP2 | WNT4 | 14525934 25348397 9853965 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| HSPA5 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| CAMK2D | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| TFCP2 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| PTEN | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| FBLN1 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| P2RX4 | WNT4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PORCN | WNT4 | 10866835 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| WNT7B | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| RAD51C | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| SFRP1 | WNT4 | 11287180 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| FZD6 | WNT4 | 14525934 15265686 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| WNT4 | APP | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | WLS | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | BORA | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | PASK | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | INTS14 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | TOMM40 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | MTCH2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | CRELD2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | CBWD3 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | ITPA | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | LMF1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | FRAS1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | N4BP2L2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | FSTL1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | COL6A1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | TMEM80 | 24234451 25348397 27107012 | physical association | validated two hybrid,barcode fusion genetics two hybrid | ComPPI,IntAct |
| FZ | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| FZ4 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| FZ2 | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| POR | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| WLS | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| WNT4 | OTK | 21772251 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SFRP1 | WNT4 | 11287180 27898060 | inhibition,stimulant | N/A | OmniPath |
| WNT4 | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT4 | LRP6 | 15578921 27898060 | stimulant | N/A | OmniPath |
| SFRP2 | WNT4 | 1128718 27898060 9853965 | inhibition | N/A | OmniPath |
| WNT4 | FZD2 | 12325120 27898060 | stimulant | N/A | OmniPath |
| WNT4 | FZD3 | 14671310 27898060 | stimulant | N/A | OmniPath |
| WNT4 | FZD6 | 15265686 21541287 24032637 27898060 | N/A | N/A | OmniPath |