Gene Information gene info

  1. Home

GENE：APPL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APPL1
FullNmae adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24035
EnsembleID ENSG00000157500
Uniprot Q9UKG1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APPL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APPL1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APPL1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
APPL1 GO:0001726,GO:0001786,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005769,GO:0005829,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0008286,GO:0008286,GO:0008286,GO:0010008,GO:0010008,GO:0010008,GO:0010762,GO:0012506,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0032009,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0042802,GO:0042803,GO:0043422,GO:0043422,GO:0044354,GO:0044877,GO:0045088,GO:0046324,GO:0046326,GO:0048023,GO:0048487,GO:0070062,GO:0097708,GO:0098793,GO:0098794,GO:0098978,GO:0098978,GO:0099558,GO:0099558,GO:1900017,GO:1903076,GO:1905303,GO:1905450,GO:2000045

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
APPL1 hsa:26060 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
APPL1 hsa:26060 path:hsa05200 Pathways in cancer - Homo sapiens (human)
APPL1 hsa:26060 path:hsa05210 Colorectal cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APPL1 FSHR 15070827 23180781 physical association anti tag coimmunoprecipitation InnateDB
APPL1 AKT2 10490823 15070827 17030088 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
APPL1 APPL2 17030088 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1 APPL1 10490823 23180781 physical association anti tag coimmunoprecipitation InnateDB
APPL1 AKT3 10490823 23180781 physical association anti tag coimmunoprecipitation InnateDB
APPL1 PIK3CA 10490823 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
APPL1 FSHR 20005715 interaction type N/A PSP
APPL1 AKT1 20005715 interaction type N/A PSP
APPL1 AKT2 10490823 20005715 21071413 interaction type N/A PSP,SignaLink
APPL1 PIK3CA 20005715 interaction type N/A PSP
APPL1 AKT1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR APPL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 APPL1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 APPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 APPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS APPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 APPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 APPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007FBA APPL1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000F31F4 APPL1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 APPL1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C APPL1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002FC5B0 APPL1 20371350 22473208 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000009262D APPL1 18591254 22473208 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000070B1D APPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 APPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D APPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 APPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 APPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 APPL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D APPL1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042E8CC APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 APPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A APPL1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E APPL1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000247AC6 APPL1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA APPL1 22135298 phosphorylation N/A PhosphoSite
PRKCA APPL1 22135298 phosphorylation N/A PhosphoSite
RAB5A APPL1 25361965 interaction type N/A PTMCode2
APPL1 RAB5A 25361965 interaction type N/A PTMCode2
PIK3CA APPL1 25361965 interaction type N/A PTMCode2
APPL1 PIK3CA 25361965 interaction type N/A PTMCode2
APPL1 ADIPOR1 25361965 interaction type N/A PTMCode2
ADIPOR1 APPL1 25361965 interaction type N/A PTMCode2
APPL1 RBBP4 25361965 interaction type N/A PTMCode2
RBBP4 APPL1 25361965 interaction type N/A PTMCode2
APPL1 RBBP7 25361965 interaction type N/A PTMCode2
RBBP7 APPL1 25361965 interaction type N/A PTMCode2
APPL1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 APPL1 25361965 interaction type N/A PTMCode2
APPL1 FSHR 25361965 interaction type N/A PTMCode2
FSHR APPL1 25361965 interaction type N/A PTMCode2
APPL1 DCC 25361965 interaction type N/A PTMCode2
DCC APPL1 25361965 interaction type N/A PTMCode2
AKT1 APPL1 25361965 interaction type N/A PTMCode2
APPL1 AKT1 25361965 interaction type N/A PTMCode2
APPL2 APPL1 25361965 interaction type N/A PTMCode2
APPL1 APPL2 25361965 interaction type N/A PTMCode2
RAB21 APPL1 25361965 interaction type N/A PTMCode2
APPL1 RAB21 25361965 interaction type N/A PTMCode2
MBD3 APPL1 25361965 interaction type N/A PTMCode2
APPL1 MBD3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FARS2 APPL1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R2 APPL1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GATAD2B APPL1 15016378 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PLEKHF2 APPL1 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
PNMA5 APPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF6 APPL1 25348397 N/A physical interaction ComPPI
GIPC2 APPL1 25348397 N/A physical interaction ComPPI
APPL1 MAGEA9 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPL1 TRAF2 14525934 16189514 24234451 25241761 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
APPL1 APPL2 14525934 15016378 16189514 23414517 24234451 25348397 25416956 colocalization,physical association two hybrid,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,fluorescence microscopy,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
APPL1 DCC 12011067 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
APPL1 AKT1 12621049 14525934 24234451 25241761 25348397 25814554 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
APPL1 RAB5A 14525934 15016378 17581628 24234451 25348397 29568061 colocalization,association,physical association experimental interaction detection,pull down,surface plasmon resonance,physical interaction,two hybrid array,fluorescence microscopy,in vitro,in vivo,two hybrid prey pooling approach,proximity-dependent biotin identification ComPPI,HPRD,IntAct
APPL1 MTA2 14525934 15016378 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
APPL1 PIK3CA 10490823 14525934 24234451 25241761 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
APPL1 ADIPOR1 14525934 16622416 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro,in vivo,bimolecular fluorescence complementation,two hybrid ComPPI,HPRD,IntAct
APPL1 FSHR 14525934 15070827 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
APPL1 AKT2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
APPL1 HDAC1 15016378 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
APPL1 HDAC2 15016378 23752268 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPL1 RBBP4 15016378 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
APPL1 RBBP7 14525934 15016378 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
APPL1 RUVBL2 25348397 N/A physical interaction ComPPI
APPL1 ELAVL1 25348397 N/A physical interaction ComPPI
APPL1 ADIPOR2 24234451 25348397 physical association fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
APPL1 RAB21 17581628 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
APPL1 VCP 25348397 N/A physical interaction ComPPI
APPL1 EGFR 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
APPL1 PIK3R1 25348397 N/A physical interaction ComPPI
APPL1 AR 25348397 N/A physical interaction ComPPI
APPL1 HDAC3 23752268 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPL1 HDAC5 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPL1 DPYSL5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL1 KXD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL1 CMTM4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL1 CLUH 25348397 N/A physical interaction ComPPI
APPL1 RELCH 25348397 N/A physical interaction ComPPI
APPL1 TTC4 25348397 N/A physical interaction ComPPI
APPL1 MEOX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPL1 UBE2O 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPL1 RHEBL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPL1 MAP3K1 25348397 N/A physical interaction ComPPI
APPL1 PHAF1 25348397 N/A physical interaction ComPPI
APPL1 NTRK1 25348397 N/A physical interaction ComPPI
APPL1 BRWD1 25348397 N/A physical interaction ComPPI
APPL1 RTCB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
APPL1 DOK3 25348397 N/A physical interaction ComPPI
APPL1 DOK7 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 INO80E 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 KLF15 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 MAGEC3 25348397 N/A physical interaction ComPPI
APPL1 ZNF829 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 CBL 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 CBLB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 DOK2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 ID1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 SOCS6 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 SCAPER 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL1 TP53 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
APPL1 TGFBR1 25348397 N/A physical interaction ComPPI
APPL1 PRKCZ 25348397 N/A physical interaction ComPPI
APPL1 MC1R 25348397 N/A physical interaction ComPPI
APPL1 TUBB3 25348397 N/A physical interaction ComPPI
APPL1 ZNF830 25348397 N/A physical interaction ComPPI
APPL1 TPCN2 25348397 N/A physical interaction ComPPI
APPL1 FAM167A 25348397 N/A physical interaction ComPPI
APPL1 KLHL2 25348397 N/A physical interaction ComPPI
APPL1 OCRL 17765681 18307981 20133602 21233288 21378754 21666675 24234451 25348397 27898060 physical association pull down,physical interaction,inference by socio-affinity scoring ComPPI,IntAct,OmniPath
APPL1 CLTA 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
APPL1 CLTB 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
APPL1 EIF3CL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
APPL1 RAB22A 17581628 24234451 25348397 N/A pull down ComPPI,IntAct
APPL1 MBD3 15016378 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
APPL1 CTNNB1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
APPL1 RXRB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
APPL1 ACTN2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
APPL1 DYSF 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
APPL1 DST 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
APPL1 SYNE2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
APPL1 AGL 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 ANKRD1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 ATP2A1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 CTTNBP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 BIN1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 DACT1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 DNM2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 GPC3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 DTNA 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 CIPC 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 LUC7L 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 HSPB1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 MYCBP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 MYH3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 SPART 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 C1QTNF9 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
APPL1 LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
APPL1 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APPL1 UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APPL1 UBE2N 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APPL1 RAB5C 24234451 25266290 25348397 colocalization confocal microscopy ComPPI,IntAct
APPL1 TGFBRAP1 24234451 25266290 25348397 colocalization confocal microscopy ComPPI,IntAct
APPL1 ADI1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPL1 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APPL1 EEA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APPL1 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APPL1 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BATF3 APPL1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 APPL1 17502098 17581628 24234451 25416956 physical association biophysical,two hybrid,x-ray crystallography,two hybrid array,two hybrid prey pooling approach IntAct
PRKACA APPL1 17765681 27898060 N/A N/A OmniPath
PRKCA APPL1 20095645 27898060 N/A N/A OmniPath
APPL1 STK11 19520843 27898060 stimulant N/A OmniPath
APPL1 AKT1 10490823 12621049 25241761 25814554 27898060 N/A N/A OmniPath
APPL1 PIK3CA 10490823 25241761 27898060 N/A N/A OmniPath
AKT3 APPL1 10490823 27898060 N/A N/A OmniPath
AKT2 APPL1 10490823 15070827 17030088 27898060 N/A N/A OmniPath
APPL1 AKT2 10490823 15070827 17030088 27898060 N/A N/A OmniPath
ADIPOR2 APPL1 16622416 27898060 stimulant N/A OmniPath
ADIPOR1 APPL1 16622416 23762377 27898060 stimulant N/A OmniPath

Visualization










  Return