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GENE：CD14

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD14
FullNmae CD14 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1628
EnsembleID ENSG00000170458
Uniprot P08571

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD14 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD14 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CD14 GO:0001530,GO:0001530,GO:0001819,GO:0001847,GO:0001875,GO:0002752,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005794,GO:0005886,GO:0006898,GO:0006909,GO:0006915,GO:0006954,GO:0007166,GO:0009897,GO:0009897,GO:0010008,GO:0016019,GO:0030667,GO:0031663,GO:0031666,GO:0032026,GO:0032481,GO:0032729,GO:0032757,GO:0032760,GO:0032760,GO:0034142,GO:0034142,GO:0034145,GO:0034612,GO:0045087,GO:0045121,GO:0045121,GO:0045471,GO:0045807,GO:0046696,GO:0046696,GO:0051602,GO:0070062,GO:0070891,GO:0071219,GO:0071222,GO:0071222,GO:0071222,GO:0071223,GO:0071726,GO:0071727

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD14 hsa:929 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CD14 hsa:929 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
CD14 hsa:929 path:hsa04145 Phagosome - Homo sapiens (human)
CD14 hsa:929 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
CD14 hsa:929 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CD14 hsa:929 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
CD14 hsa:929 path:hsa05131 Shigellosis - Homo sapiens (human)
CD14 hsa:929 path:hsa05132 Salmonella infection - Homo sapiens (human)
CD14 hsa:929 path:hsa05133 Pertussis - Homo sapiens (human)
CD14 hsa:929 path:hsa05134 Legionellosis - Homo sapiens (human)
CD14 hsa:929 path:hsa05146 Amoebiasis - Homo sapiens (human)
CD14 hsa:929 path:hsa05152 Tuberculosis - Homo sapiens (human)
CD14 hsa:929 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
CD14 hsa:929 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
CD14 hsa:929 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD14 TIRAP 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 PYCARD 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 CXCL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 IRAK1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
HMGB1 CD14 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
LTF CD14 11083760 18364398 23180781 24088817 26192618 interaction type,physical association affinity chromatography technology,biosensor ACSN,InnateDB
CD14 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 VEGFA 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
CD14 TLR4 11745332 12196527 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
TLR2 CD14 10395652 11986301 23180781 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
TLR3 CD14 21078886 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR7 CD14 21078886 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR8 CD14 21078886 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD14 TLR9 21078886 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD14 MZF1 18495781 23180781 physical association electrophoretic mobility supershift assay InnateDB
CD14 CREB1 17327484 23180781 physical association electrophoretic mobility supershift assay InnateDB
CD14 VDR 23180781 24185200 physical association anti tag coimmunoprecipitation InnateDB
CD14 ITGAM 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 CD81 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 FCGR3A 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 CD36 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 CD55 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 FCGR2A 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 FCGR1A 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
CD14 CD47 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB
LBP CD14 12417309 23180781 physical association surface plasmon resonance InnateDB
CD33 CD14 23180781 25059667 physical association anti tag coimmunoprecipitation InnateDB
LYN CD14 23180781 26055819 physical association anti tag coimmunoprecipitation InnateDB
CD14 LYN 23180781 26055819 physical association anti tag coimmunoprecipitation InnateDB
CD14 PIK3R1 23180781 26055819 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 CD14 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CD14 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CD14 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C CD14 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 CD14 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CD14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 CD14 17762869 trascriptional regulation,stimulation inferred by curator TFlink
MEF2D CD14 12213324 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CD14 11698458 17203216 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CD14 11698458 17203216 trascriptional regulation,stimulation inferred by curator TFlink
SP2 CD14 11698458 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CD14 11698458 trascriptional regulation,stimulation inferred by curator TFlink
VDR CD14 16402404 trascriptional regulation,stimulation inferred by curator TFlink
WT1 CD14 9484784 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD14 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPB CD14 N/A trascriptional regulation,stimulation inferred by curator TFlink
RELB CD14 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CD14 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
LGALS3BP CD14 25361965 interaction type N/A PTMCode2
CD14 LGALS3BP 25361965 interaction type N/A PTMCode2
FSTL1 CD14 25361965 interaction type N/A PTMCode2
CD14 FSTL1 25361965 interaction type N/A PTMCode2
LBP CD14 25361965 interaction type N/A PTMCode2
CD14 LBP 25361965 interaction type N/A PTMCode2
ITGB2 CD14 25361965 interaction type N/A PTMCode2
CD14 ITGB2 25361965 interaction type N/A PTMCode2
CD14 CD55 25361965 interaction type N/A PTMCode2
CD55 CD14 25361965 interaction type N/A PTMCode2
CD14 DIP2A 25361965 interaction type N/A PTMCode2
DIP2A CD14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TAF9 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF1 CD14 25348397 N/A physical interaction ComPPI
ITGB2 CD14 25348397 N/A in vitro ComPPI
LTF CD14 11083760 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LBP CD14 12417309 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD
TLR2 CD14 10395652 14525934 18765807 24234451 25348397 N/A experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo ComPPI,HPRD,IntAct
TLR4 CD14 12196527 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNFRSF1B CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK3 CD14 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
SVIL CD14 25348397 N/A physical interaction ComPPI
ICAM5 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1B CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DIP2A CD14 20860622 24234451 25348397 physical association competition binding ComPPI,IntAct
PHF21A CD14 25348397 N/A physical interaction ComPPI
AP3S1 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2J CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TLR3 CD14 14525934 16473828 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPP1R12B CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OASL CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARID2 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HPS5 CD14 25348397 N/A physical interaction ComPPI
ARFGAP3 CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LGALS3BP CD14 14525934 25348397 7583357 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD55 CD14 11745332 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GJB2 CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD14 ANXA7 25348397 N/A physical interaction ComPPI
CD14 AK6 25348397 N/A physical interaction ComPPI
CD14 PHF20L1 25348397 N/A physical interaction ComPPI
CD14 BCAS3 25348397 N/A physical interaction ComPPI
CD14 WDCP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD14 FSTL1 20860622 22265692 24234451 25348397 27898060 physical association two hybrid,fluorescence-activated cell sorting,surface plasmon resonance ComPPI,IntAct,OmniPath
CD14 CD33 24234451 25348397 28325905 physical association proximity ligation assay ComPPI,IntAct
PPP3R2 CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD14 ITGB1 17274987 27898060 N/A N/A OmniPath
CD14 TLR8 21078886 27898060 N/A N/A OmniPath
TLR4 CD14 11745332 12196527 17535871 27898060 N/A N/A OmniPath
CD14 TLR4 11745332 12196527 17535871 27898060 stimulant N/A OmniPath
CD14 TLR2 10395652 11986301 18765807 27898060 stimulant N/A OmniPath
CD14 TLR9 21078886 27898060 N/A N/A OmniPath
CD14 LBP 12417309 17535871 2402637 27898060 7583357 N/A N/A OmniPath
CEBPA CD14 15676205 27898060 stimulant N/A OmniPath
CD14 ITGAM 11745332 27898060 N/A N/A OmniPath
CD14 TLR3 16473828 21078886 27898060 stimulant N/A OmniPath
LTF CD14 11083760 27898060 N/A N/A OmniPath
CD14 TLR7 21078886 27898060 N/A N/A OmniPath
CD14 FCGR1A 11745332 27898060 N/A N/A OmniPath
CD14 FCGR2A 11745332 27898060 N/A N/A OmniPath
CD14 CD55 11745332 27898060 N/A N/A OmniPath
CD14 CD36 11745332 27898060 N/A N/A OmniPath
CD14 ITGA4 17274987 27898060 N/A N/A OmniPath
CD14 CD81 11745332 27898060 N/A N/A OmniPath
CD33 CD14 25059667 27898060 N/A N/A OmniPath
CD14 CD47 11745332 27898060 N/A N/A OmniPath
CD14 FCGR3A 11745332 27898060 N/A N/A OmniPath

Visualization










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