GENE：CRH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CRH |
| FullNmae | corticotropin releasing hormone |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2355 |
| EnsembleID | ENSG00000147571 |
| Uniprot | P06850 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CRH | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CRH | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CRH | GO:0001963,GO:0005102,GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006704,GO:0006954,GO:0007165,GO:0007268,GO:0007565,GO:0007567,GO:0007611,GO:0010841,GO:0017045,GO:0030324,GO:0030325,GO:0032811,GO:0035641,GO:0042322,GO:0043025,GO:0045202,GO:0051461,GO:0051464,GO:0051464,GO:0070093,GO:2000310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CRH | hsa:1392 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| CRH | hsa:1392 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| CRH | hsa:1392 | path:hsa04730 | Long-term depression - Homo sapiens (human) |
| CRH | hsa:1392 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| CRH | hsa:1392 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | CRH | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CRH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CRH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CRH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CRH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CRH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | CRH | 16446741 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR1 | CRH | 12161509 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR2 | CRH | 12161509 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR4A2 | CRH | 11315917 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | CRH | 19596122 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | CRH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRTAP5-9 | CRH | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | CRH | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRT31 | CRH | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CRH | CRHR2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| CRH | CRHR1 | 14525934 18801728 24234451 25348397 9178757 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vivo,amplified luminescent proximity homogeneous assay | ComPPI,HPRD,IntAct |
| CRH | UBR1 | 25348397 | N/A | physical interaction | ComPPI |
| CRH | RRAS | 25348397 | N/A | physical interaction | ComPPI |
| CRH | MDFI | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CRH | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CRH | KRTAP1-5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CRH | NOTCH2NLA | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CRH | KRTAP9-3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CRH | CRH | 14525934 9178757 | N/A | experimental interaction detection | HPRD |
| CRH | CRHR2 | 27898060 8243338 8536644 | stimulant | N/A | OmniPath |
| CRH | CRHR1 | 10598591 11416224 18801728 27898060 8536644 9178757 9423932 | stimulant | N/A | OmniPath |