Gene Information gene info

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GENE：DCC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DCC
FullNmae DCC netrin 1 receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2701
EnsembleID ENSG00000187323
Uniprot P43146

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DCC apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DCC apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DCC GO:0001764,GO:0004888,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0006915,GO:0007409,GO:0007411,GO:0009986,GO:0010977,GO:0021965,GO:0033563,GO:0033564,GO:0044295,GO:0048671,GO:0098609,GO:0098685,GO:0098839,GO:0099170,GO:2000171

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DCC hsa:1630 path:hsa04360 Axon guidance - Homo sapiens (human)
DCC hsa:1630 path:hsa05200 Pathways in cancer - Homo sapiens (human)
DCC hsa:1630 path:hsa05210 Colorectal cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NTN1 DCC 11248093 11989976 17613518 17959595 19543238 19931333 20173780 20495383 22920895 26192618 26618107 9765224 interaction type N/A ACSN
DCC CREB1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
DCC LYL1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F1 DCC 12629508 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DCC 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DCC 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 DCC 15843459 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DCC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 DCC 19745029 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000045B99E DCC 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 DCC 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 DCC 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 DCC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004ACAAA DCC 25416803 26043902 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
NCK1 DCC 25361965 interaction type N/A PTMCode2
DCC NCK1 25361965 interaction type N/A PTMCode2
APPL1 DCC 25361965 interaction type N/A PTMCode2
DCC APPL1 25361965 interaction type N/A PTMCode2
MAPK1 DCC 25361965 interaction type N/A PTMCode2
DCC MAPK1 25361965 interaction type N/A PTMCode2
CASP9 DCC 25361965 interaction type N/A PTMCode2
DCC CASP9 25361965 interaction type N/A PTMCode2
SIAH1 DCC 25361965 interaction type N/A PTMCode2
DCC SIAH1 25361965 interaction type N/A PTMCode2
NTN1 DCC 25361965 interaction type N/A PTMCode2
DCC NTN1 25361965 interaction type N/A PTMCode2
CASP3 DCC 25361965 interaction type N/A PTMCode2
DCC CASP3 25361965 interaction type N/A PTMCode2
EZR DCC 25361965 interaction type N/A PTMCode2
DCC EZR 25361965 interaction type N/A PTMCode2
SIAH2 DCC 25361965 interaction type N/A PTMCode2
DCC SIAH2 25361965 interaction type N/A PTMCode2
ADORA2B DCC 25361965 interaction type N/A PTMCode2
DCC ADORA2B 25361965 interaction type N/A PTMCode2
PITPNA DCC 25361965 interaction type N/A PTMCode2
DCC PITPNA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FBP1 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ANP32B DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EIF2B2 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 DCC 21642953 24234451 25348397 physical association competition binding ComPPI,IntAct
CASP9 DCC 11248093 14525934 16537496 19721007 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
EIF3E DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL10A DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
APPL1 DCC 12011067 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAPK1 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 DCC 14525934 25348397 9858595 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCK1 DCC 12149262 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 DCC 11248093 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK3 DCC 11986622 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AR DCC 25348397 N/A physical interaction ComPPI
SFRP2 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SIAH1 DCC 14525934 25348397 9858595 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PITPNA DCC 14525934 16244667 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
RPL28 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
EIF2S1 DCC 20434207 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
RPS6 DCC 20434207 24234451 25348397 association cosedimentation through density gradient,physical interaction ComPPI,IntAct
RPS13 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RASA1 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ALDOB DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EIF2S3 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF1AX DCC 25348397 N/A physical interaction ComPPI
CORO2A DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BARD1 DCC 25348397 N/A physical interaction ComPPI
RPL5 DCC 20434207 24234451 25348397 association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
MAPKAPK3 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EIF2B1 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2S2 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAZ DCC 11527412 12509857 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
MYO10 DCC 21642953 24234451 25348397 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,x-ray crystallography ComPPI,IntAct
NTN1 DCC 12810718 14525934 19721007 20434207 24234451 25348397 26190107 9950216 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,solid phase assay,avexis ComPPI,HPRD,IntAct
ADORA2B DCC 11048721 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
EIF4E DCC 25348397 N/A physical interaction ComPPI
RPL13 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL23 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS10 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B4 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TDRD7 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EZR DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TMOD1 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EIF5A2 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC PTK2 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC EIF2S3B 25348397 N/A physical interaction ComPPI
DCC RPL38 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC RPS24 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC EIF4E3 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC EIF2A 25348397 N/A physical interaction ComPPI
DCC RPS4X 25348397 N/A physical interaction ComPPI
DCC ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCC NTN4 19721007 24234451 25348397 N/A physical interaction,solid phase assay ComPPI,IntAct
DCC RPS23 20434207 24234451 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
DCC TRMO 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DCC TSTD2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DCC CTSV 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DCC HEMGN 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DCC TBC1D2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RRBP1 DCC 24234451 30021884 physical association cross-linking study IntAct
NTN1 DCC 11239160 12810718 19721007 20434207 26190107 27898060 8861902 9950216 stimulant N/A OmniPath

Visualization










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