Gene Information gene info

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GENE：KRT8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KRT8
FullNmae keratin 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6446
EnsembleID ENSG00000170421
Uniprot P05787

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KRT8 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KRT8 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KRT8 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
KRT8 GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005882,GO:0005911,GO:0016010,GO:0016327,GO:0016363,GO:0030018,GO:0033209,GO:0042383,GO:0043034,GO:0044877,GO:0045095,GO:0045111,GO:0045214,GO:0051599,GO:0051707,GO:0060706,GO:0070062,GO:0097110,GO:0097191,GO:0097284

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KRT8 TNFRSF1B 10747083 23180781 physical association pull down InnateDB
MAPK1 KRT8 11788583 23180781 phosphorylation reaction in-gel kinase assay InnateDB
KRT8 MAPK14 11788583 23180781 phosphorylation reaction,physical association far western blotting,in-gel kinase assay InnateDB
IKBKG KRT8 20098747 23180781 physical association protein array InnateDB
EED KRT8 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
KRT8 RAF1 20005715 interaction type N/A PSP
KRT8 MAPK3 20005715 interaction type N/A PSP,SignaLink
KRT8 MAPK1 20005715 interaction type N/A PSP
KRT8 MAPK8 20005715 interaction type N/A PSP
KRT8 PRKCE 20005715 interaction type N/A PSP
KRT8 MAPK14 20005715 interaction type N/A PSP
KRT8 MAPK1 11788583 20005715 20005715 21071413 N/A N/A SignaLink
KRT8 MAPK14 11788583 11788583 20005715 20005715 21071413 N/A N/A SignaLink
KRT8 MAPK8 11781324 20005715 20005715 21071413 N/A N/A SignaLink
KRT8 RAF1 15314064 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 KRT8 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 KRT8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 KRT8 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 KRT8 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 KRT8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 KRT8 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 KRT8 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001F8FF2 KRT8 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 KRT8 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 KRT8 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 KRT8 24398324 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD KRT8 22135298 phosphorylation N/A PhosphoSite
MAPK3 KRT8 22135298 phosphorylation N/A PhosphoSite
CDK1 KRT8 22135298 phosphorylation N/A PhosphoSite
MAPK14 KRT8 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K1 KRT8 22135298 phosphorylation N/A PhosphoSite
MAP2K2 KRT8 22135298 phosphorylation N/A PhosphoSite
AURKB KRT8 22135298 phosphorylation N/A PhosphoSite
MAPK8 KRT8 22135298 phosphorylation N/A PhosphoSite
PKP1 KRT8 25361965 interaction type N/A PTMCode2
KRT8 PKP1 25361965 interaction type N/A PTMCode2
MAPK1 KRT8 25361965 interaction type N/A PTMCode2
KRT8 MAPK1 25361965 interaction type N/A PTMCode2
ANXA1 KRT8 25361965 interaction type N/A PTMCode2
KRT8 ANXA1 25361965 interaction type N/A PTMCode2
KRT8 TCHP 25361965 interaction type N/A PTMCode2
TCHP KRT8 25361965 interaction type N/A PTMCode2
KRT8 PPL 25361965 interaction type N/A PTMCode2
PPL KRT8 25361965 interaction type N/A PTMCode2
KRT8 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 KRT8 25361965 interaction type N/A PTMCode2
KRT8 KRT18 25361965 interaction type N/A PTMCode2
KRT18 KRT8 25361965 interaction type N/A PTMCode2
PNN KRT8 25361965 interaction type N/A PTMCode2
KRT8 PNN 25361965 interaction type N/A PTMCode2
KRT8 MAPK14 25361965 interaction type N/A PTMCode2
TROAP KRT8 25361965 interaction type N/A PTMCode2
KRT8 TROAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 KRT8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BYSL KRT8 14525934 24234451 25348397 9560222 association two hybrid,experimental interaction detection,physical interaction,in vitro,three hybrid,two hybrid ComPPI,HPRD,IntAct
PPL KRT8 22841549 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
KRT18 KRT8 10852826 10954706 11684708 14525934 14756564 21988832 24234451 25348397 30021884 9630597 colocalization,physical association biophysical,two hybrid,cosedimentation,cosedimentation in solution,cross-linking study,experimental interaction detection,physical interaction,two hybrid array,fluorescence microscopy,in vivo,confocal microscopy,two hybrid prey pooling approach ComPPI,HPRD,IntAct
KRT19 KRT8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCHP KRT8 14525934 15731013 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
UBASH3B KRT8 25348397 N/A physical interaction ComPPI
KRT38 KRT8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ANXA1 KRT8 14525934 25348397 27898060 9459484 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
VIM KRT8 15846844 24234451 25348397 30021884 association,physical association anti bait coimmunoprecipitation,cross-linking study ComPPI,IntAct
WBP2 KRT8 25348397 N/A physical interaction ComPPI
TRAF6 KRT8 25348397 N/A physical interaction ComPPI
KEAP1 KRT8 25348397 N/A physical interaction ComPPI
KRT33B KRT8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT31 KRT8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 KRT8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRK KRT8 25348397 N/A physical interaction ComPPI
MAPK1 KRT8 11781324 11788583 14525934 25348397 9211903 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8 KRT8 11781324 11788583 14525934 25348397 9211903 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK3 KRT8 11781324 11788583 14525934 25348397 9054461 9211903 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB2 KRT8 12577067 20936779 24234451 25348397 association,physical association pull down,physical interaction,two hybrid pooling approach ComPPI,IntAct
MAPK14 KRT8 11781324 11788583 14525934 25348397 9211903 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCE KRT8 25348397 N/A physical interaction ComPPI
YWHAZ KRT8 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CDH1 KRT8 25348397 N/A physical interaction ComPPI
PKD1 KRT8 11581269 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PKP2 KRT8 10852826 24234451 25348397 physical association far western blotting ComPPI,IntAct
PLAT KRT8 14525934 25348397 27898060 9988531 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
YBX1 KRT8 23986595 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CAV1 KRT8 25348397 N/A physical interaction ComPPI
HSPA5 KRT8 14525934 25348397 9409741 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CLK1 KRT8 25348397 N/A physical interaction ComPPI
STAM2 KRT8 25348397 N/A physical interaction ComPPI
CFTR KRT8 22038833 24234451 25348397 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,surface plasmon resonance,confocal microscopy,proximity ligation assay ComPPI,IntAct,OmniPath
YWHAQ KRT8 25348397 N/A physical interaction ComPPI
EGFR KRT8 12577067 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FGFR3 KRT8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RAF1 KRT8 14525934 15314064 24234451 25348397 association experimental interaction detection,in vivo ComPPI,HPRD,IntAct
NOS2 KRT8 25348397 N/A physical interaction ComPPI
RCHY1 KRT8 25348397 N/A physical interaction ComPPI
VCAM1 KRT8 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 KRT8 25348397 N/A physical interaction ComPPI
EED KRT8 25348397 N/A physical interaction ComPPI
PKP1 KRT8 10852826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPP6C KRT8 25348397 N/A physical interaction ComPPI
TFIP11 KRT8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEDD KRT8 12235123 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ESR1 KRT8 25348397 N/A physical interaction ComPPI
TADA2A KRT8 25348397 N/A physical interaction ComPPI
PPEF2 KRT8 25348397 N/A physical interaction ComPPI
PNN KRT8 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
IQCB1 KRT8 25348397 N/A physical interaction ComPPI
DNAJB6 KRT8 10954706 24234451 25348397 physical association cosedimentation,cosedimentation in solution ComPPI,IntAct
TROAP KRT8 24234451 25348397 9560222 association pull down,physical interaction,three hybrid ComPPI,IntAct
FAF2 KRT8 25348397 N/A physical interaction ComPPI
PAN2 KRT8 25348397 N/A physical interaction ComPPI
ATF2 KRT8 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TES KRT8 25348397 N/A physical interaction ComPPI
KRT8 HSPA4L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KRT8 CLN5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KRT8 KRT17 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
KRT8 OTUD4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRT8 USP32 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRT8 IKBKG 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
KRT8 TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
KRT8 QRSL1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KRT8 APEX1 25348397 N/A physical interaction ComPPI
KRT8 FN1 25348397 N/A physical interaction ComPPI
KRT8 FBXO25 25348397 N/A physical interaction ComPPI
KRT8 ASB12 25348397 N/A physical interaction ComPPI
KRT8 MTMR8 25348397 N/A physical interaction ComPPI
KRT8 KRT13 25348397 N/A physical interaction ComPPI
KRT8 KRT15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT8 CYLD 25348397 N/A physical interaction ComPPI
KRT8 DSP 25348397 N/A two hybrid,physical interaction ComPPI
KRT8 DMD 14525934 16000376 24234451 25348397 association experimental interaction detection,far western blotting ComPPI,HPRD,IntAct
KRT8 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT28 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT24 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT25 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 KRT27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT8 LILRB3 24234451 25348397 26769854 association affinity chromatography technology,confocal microscopy ComPPI,IntAct
PASK KRT8 21418524 24234451 25348397 phosphorylation reaction peptide array ComPPI,IntAct
METTL14 KRT8 24234451 29507755 association anti tag coimmunoprecipitation IntAct
KRT8 PRR22 24234451 30021884 physical association cross-linking study IntAct
KRT8 GPR37 24234451 30021884 physical association cross-linking study IntAct
PLEC KRT8 24234451 30021884 physical association cross-linking study IntAct
KRT8 ZNF804B 24234451 30021884 physical association cross-linking study IntAct
KRT8 MEIKIN 24234451 30021884 physical association cross-linking study IntAct
KRT8 MTRF1 24234451 30021884 physical association cross-linking study IntAct
KRT8 NLN 24234451 30021884 physical association cross-linking study IntAct
KRT8 LSG1 24234451 30021884 physical association cross-linking study IntAct
KRT8 UACA 24234451 30021884 physical association cross-linking study IntAct
KRT8 DCDC1 24234451 30021884 physical association cross-linking study IntAct
KRT8 LCP2 24234451 30021884 physical association cross-linking study IntAct
KRT8 ZNF484 24234451 30021884 physical association cross-linking study IntAct
KRT8 IRAK3 24234451 30021884 physical association cross-linking study IntAct
NEUROD2 KRT8 24234451 30021884 physical association cross-linking study IntAct
KRT8 AHCTF1 24234451 30021884 physical association cross-linking study IntAct
KRT8 LRP8 24234451 30021884 physical association cross-linking study IntAct
KRT8 PEX5L 24234451 30021884 physical association cross-linking study IntAct
KRT8 CCDC96 24234451 30021884 physical association cross-linking study IntAct
KRT8 CUX1 24234451 30021884 physical association cross-linking study IntAct
KRT8 CCDC71 24234451 30021884 physical association cross-linking study IntAct
MYH1 KRT8 24234451 30021884 physical association cross-linking study IntAct
NES KRT8 24234451 30021884 physical association cross-linking study IntAct
KRT8 ARFGEF1 24234451 30021884 physical association cross-linking study IntAct
KRT8 CD4 24234451 30021884 physical association cross-linking study IntAct
KRT8 ZNF708 24234451 30021884 physical association cross-linking study IntAct
KRT8 TTN 24234451 30021884 physical association cross-linking study IntAct
KRT8 TTC33 24234451 30021884 physical association cross-linking study IntAct
KRT8 F11 24234451 30021884 physical association cross-linking study IntAct
KRT8 GDPD4 24234451 30021884 physical association cross-linking study IntAct
KRT8 ZNF704 24234451 30021884 physical association cross-linking study IntAct
KRT8 ITPR3 24234451 30021884 physical association cross-linking study IntAct
KRT8 C2ORF78 24234451 30021884 physical association cross-linking study IntAct
KRT8 NAA10 24234451 30021884 physical association cross-linking study IntAct
KRT8 OVCH1 24234451 30021884 physical association cross-linking study IntAct
KRT8 AP3B1 24234451 30021884 physical association cross-linking study IntAct
KRT8 ADAM12 24234451 30021884 physical association cross-linking study IntAct
KRT8 TRAPPC11 24234451 30021884 physical association cross-linking study IntAct
PRKCD KRT8 15972820 27898060 N/A N/A OmniPath
MAP2K2 KRT8 10623656 11781324 11788583 15368451 15707998 15763073 15972820 16343483 16554440 17535969 18617517 19115206 19246484 19796649 20663917 20724476 22114688 23358244 25963979 27898060 9211903 N/A N/A OmniPath
ESR1 KRT8 14605097 27898060 stimulant N/A OmniPath
MAPK13 KRT8 11788583 27898060 stimulant N/A OmniPath
IKBKG KRT8 20098747 21988832 27898060 N/A N/A OmniPath
MAPK3 KRT8 11781324 11788583 17158917 18669648 18691976 19007248 21840417 22344252 23241311 26303380 27898060 9054461 9211903 9524113 N/A N/A OmniPath
TP53 KRT8 18431400 27898060 stimulant N/A OmniPath
MAPK14 KRT8 11781324 11788583 18691976 19007248 27898060 9054461 9211903 stimulant N/A OmniPath
CDK1 KRT8 27898060 9054461 9524113 stimulant N/A OmniPath
MAPK1 KRT8 11781324 11788583 18691976 19007248 27898060 9211903 N/A N/A OmniPath
PPP2CA KRT8 16554440 27898060 N/A N/A OmniPath
MAPK11 KRT8 11788583 27898060 stimulant N/A OmniPath
MAPK8 KRT8 11781324 11788583 18691976 19007248 27898060 9211903 stimulant N/A OmniPath
MAPK12 KRT8 11788583 27898060 stimulant N/A OmniPath
PTP4A3 KRT8 19115206 27898060 inhibition N/A OmniPath
PPP2CB KRT8 16554440 27898060 N/A N/A OmniPath

Visualization










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