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GENE：LY96

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LY96
FullNmae lymphocyte antigen 96
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17156
EnsembleID ENSG00000154589
Uniprot Q9Y6Y9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LY96 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
LY96 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LY96 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LY96 GO:0001530,GO:0001875,GO:0001875,GO:0002224,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005886,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0010008,GO:0015026,GO:0031663,GO:0031666,GO:0032496,GO:0032497,GO:0032497,GO:0032760,GO:0034142,GO:0034142,GO:0035662,GO:0043235,GO:0045087,GO:0046696,GO:0046696,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LY96 hsa:23643 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
LY96 hsa:23643 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
LY96 hsa:23643 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
LY96 hsa:23643 path:hsa05132 Salmonella infection - Homo sapiens (human)
LY96 hsa:23643 path:hsa05133 Pertussis - Homo sapiens (human)
LY96 hsa:23643 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
LY96 hsa:23643 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LY96 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 TIRAP 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 LY96 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 LY96 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 PYCARD 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 CXCL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IRAK1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
HMGB1 LY96 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
LTF LY96 18364398 24088817 26192618 interaction type N/A ACSN
IFNG LY96 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
LY96 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 VEGFA 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 TLR4 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15557191 15694388 15728506 16272300 17056597 22433852 23180781 24097189 physical association affinity chromatography technology,anti tag coimmunoprecipitation,nuclear magnetic resonance,surface plasmon resonance,biotin tag,solid phase assay,surface plasmon resonance array InnateDB
LY96 LY96 11976338 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY96 SFTPA2 16754682 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY96 SFTPA1 16754682 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
LY96 TLR2 11160242 23180781 physical association anti tag coimmunoprecipitation InnateDB
SFTPD LY96 18990700 23180781 physical association affinity chromatography technology InnateDB
LY96 SFTPD 18991397 23180781 physical association anti tag coimmunoprecipitation,pull down,surface plasmon resonance InnateDB
LY96 SPI1 19632992 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY96 CEBPB 19632992 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY96 MBL2 19840833 23180781 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
LY96 LY86 15852007 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY96 AHSG 22842477 23180781 physical association surface plasmon resonance array InnateDB
LY96 S100A4 23180781 23667563 physical association affinity technology InnateDB
LY96 S100A9 23180781 23667563 physical association affinity technology InnateDB
CIRBP LY96 23180781 24097189 physical association surface plasmon resonance array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 LY96 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 LY96 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LY96 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LY96 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB5 LY96 21132541 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 LY96 21572044 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LYN LY96 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDKN2C LY96 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CALM1 LY96 25348397 N/A physical interaction ComPPI
HMGB1 LY96 20547845 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
SMARCB1 LY96 25348397 N/A physical interaction ComPPI
TLR2 LY96 25348397 N/A physical interaction,in vivo ComPPI
TLR4 LY96 15728506 17803912 20547845 24234451 25348397 physical association anti tag coimmunoprecipitation,cross-linking study,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,solid phase assay ComPPI,IntAct
MLH1 LY96 25348397 N/A physical interaction ComPPI
LY86 LY96 19060881 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LY96 MESD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LY96 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LYN LY96 21918188 27898060 N/A N/A OmniPath
TLR4 LY96 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15175334 15557191 15694388 15728506 16272300 17056597 17535871 17803912 19060881 19252480 22433852 22474354 22532668 24097189 27898060 N/A N/A OmniPath
LY96 TLR4 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15175334 15557191 15694388 15728506 16272300 17056597 17535871 17803912 19060881 19252480 22433852 22474354 22532668 24097189 27898060 N/A N/A OmniPath
TLR2 LY96 11160242 27898060 N/A N/A OmniPath
LY96 TLR2 11160242 27898060 N/A N/A OmniPath
SFTPD LY96 18990700 18991397 27898060 N/A N/A OmniPath
LY86 LY96 15852007 27898060 N/A N/A OmniPath
LY96 SFTPA1 16754682 27898060 N/A N/A OmniPath
CIRBP LY96 24097189 27898060 N/A N/A OmniPath
LY96 SFTPA2 16754682 27898060 N/A N/A OmniPath
LY96 MBL2 19840833 27898060 N/A N/A OmniPath

Visualization










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