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GENE：TICAM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TICAM2
FullNmae TIR domain containing adaptor molecule 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21354
EnsembleID ENSG00000243414
Uniprot Q86XR7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TICAM2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TICAM2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TICAM2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TICAM2 GO:0001891,GO:0002735,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0006909,GO:0006954,GO:0010008,GO:0019901,GO:0030667,GO:0031663,GO:0031901,GO:0031902,GO:0032481,GO:0032816,GO:0034145,GO:0035666,GO:0035669,GO:0042995,GO:0043123,GO:0043123,GO:0043330,GO:0045087,GO:0051092,GO:0060090,GO:0071222,GO:1900017,GO:2000494

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TICAM2 hsa:353376 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa04217 Necroptosis - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa05133 Pertussis - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa05161 Hepatitis B - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
TICAM2 hsa:353376 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR4 TICAM2 21829704 21903422 22139835 23180781 24265315 physical association anti tag coimmunoprecipitation,mammalian protein protein interaction trap InnateDB
TICAM1 TICAM2 23180781 24255114 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM2 TICAM2 14519765 23180781 24255114 26467481 bind,physical association,up-regulates activity two hybrid InnateDB,Signor
MYD88 TICAM2 23180781 24265315 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 TICAM2 23180781 24812060 physical association anti tag coimmunoprecipitation InnateDB
TICAM2 IL18R1 22685567 23180781 physical association pull down InnateDB
TICAM2 MYD88 22685567 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TICAM2 IL18RAP 22685567 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
TICAM1 TICAM2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR TICAM2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TICAM2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TICAM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TICAM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TICAM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TICAM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TICAM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 TICAM2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000F31F4 TICAM2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TICAM2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 TICAM2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000009262D TICAM2 25327529 25416803 26701625 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00000821E0 TICAM2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCE TICAM2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIAS2 TICAM2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FTH1 TICAM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MEOX2 TICAM2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF6 TICAM2 12721283 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCE TICAM2 25348397 N/A phosphorylation reaction,protein kinase assay ComPPI
IL1RAP TICAM2 12721283 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
IRF3 TICAM2 14517278 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TIRAP TICAM2 12721283 24234451 25348397 physical association coimmunoprecipitation,physical interaction,in vitro ComPPI,IntAct
AGER TICAM2 21829704 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
IRAK1 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK2 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLR4 TICAM2 14517278 14519765 14525934 14556004 17258210 21829704 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
IRAK3 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK4 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TICAM2 OPN1LW 25348397 N/A in vitro ComPPI
TICAM2 TLR3 14519765 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
TICAM2 IRF7 14517278 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TICAM2 TICAM1 12721283 14519765 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
TICAM2 IL1R1 12721283 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TICAM2 SARM1 17258210 24234451 25348397 26592460 physical association pull down,physical interaction,mammalian protein protein interaction trap ComPPI,IntAct
TICAM2 TRIM25 25348397 N/A physical interaction ComPPI
TICAM2 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TICAM2 TICAM2 14519765 14525934 17258210 24234451 physical association experimental interaction detection,mammalian protein protein interaction trap,two hybrid HPRD,IntAct
PRKCE TICAM2 16757566 27898060 stimulant N/A OmniPath
TICAM2 TICAM1 12721283 14519765 16410796 24255114 25736436 27898060 stimulant N/A OmniPath
TICAM2 TRAF6 12721283 24812060 27898060 stimulant N/A OmniPath
TRAF6 TICAM2 12721283 24812060 27898060 N/A N/A OmniPath
TLR4 TICAM2 14517278 14519765 14556004 16410796 17258210 18221795 21829704 21903422 22139835 24265315 25736436 27898060 stimulant N/A OmniPath
TICAM2 TLR4 14517278 14519765 14556004 17258210 18221795 21829704 21903422 22139835 24265315 25736436 27898060 N/A N/A OmniPath
TICAM2 MYD88 20072711 22685567 24265315 27898060 stimulant N/A OmniPath
TLR2 TICAM2 20072711 27898060 stimulant N/A OmniPath
TICAM2 IL18RAP 22685567 27898060 N/A N/A OmniPath
TICAM2 IL18R1 22685567 27898060 N/A N/A OmniPath

Visualization










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