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GENE：TLR4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR4
FullNmae toll like receptor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11850
EnsembleID ENSG00000136869
Uniprot O00206

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR4 pyroptosis 40292295 The AREG-neutralizing antibody reduced LPS-induced epidermal growth factor receptor (EGFR) activation, TLR4 expression, and pyroptosis. Extracellular AREG-induced macrophage pyroptosis decreased with EGFR and NF-κB inhibition, as well as TLR4 and Myd88 knockout. retulator signature
TLR4 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR4 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TLR4 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
TLR4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TLR4 GO:0001530,GO:0001530,GO:0001530,GO:0001540,GO:0001726,GO:0001875,GO:0001875,GO:0001891,GO:0002224,GO:0002246,GO:0002322,GO:0002537,GO:0002730,GO:0002755,GO:0002755,GO:0002755,GO:0004888,GO:0005102,GO:0005515,GO:0005737,GO:0005737,GO:0005769,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006809,GO:0006909,GO:0006954,GO:0006955,GO:0007252,GO:0007254,GO:0009897,GO:0009986,GO:0010008,GO:0010467,GO:0010572,GO:0010628,GO:0010628,GO:0014002,GO:0014004,GO:0014911,GO:0016046,GO:0030890,GO:0031663,GO:0032496,GO:0032496,GO:0032497,GO:0032497,GO:0032689,GO:0032700,GO:0032707,GO:0032715,GO:0032720,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032735,GO:0032755,GO:0032755,GO:0032757,GO:0032760,GO:0032760,GO:0032760,GO:0034142,GO:0034142,GO:0035666,GO:0036120,GO:0038023,GO:0042088,GO:0042116,GO:0042742,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0043406,GO:0045087,GO:0045087,GO:0045342,GO:0045348,GO:0045429,GO:0045671,GO:0045944,GO:0046330,GO:0046696,GO:0046982,GO:0048471,GO:0048661,GO:0050135,GO:0050729,GO:0050729,GO:0050829,GO:0050829,GO:0051092,GO:0051092,GO:0051092,GO:0051770,GO:0060729,GO:0060907,GO:0061809,GO:0070371,GO:0070373,GO:0070374,GO:0070427,GO:0070430,GO:0070431,GO:0070434,GO:0071222,GO:0071222,GO:0071222,GO:0071223,GO:0071260,GO:0071346,GO:0120163,GO:0140052,GO:0140052,GO:1900017,GO:1900017,GO:1900227,GO:1901224,GO:1903428,GO:1903974,GO:1904466,GO:1904646,GO:1904646,GO:2000343,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR4 hsa:7099 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04145 Phagosome - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04217 Necroptosis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TLR4 hsa:7099 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05131 Shigellosis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05132 Salmonella infection - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05133 Pertussis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05134 Legionellosis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05135 Yersinia infection - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05140 Leishmaniasis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05142 Chagas disease - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05144 Malaria - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05146 Amoebiasis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05152 Tuberculosis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05161 Hepatitis B - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05162 Measles - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05164 Influenza A - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
TLR4 hsa:7099 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR4 TICAM1 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573 26192618 association N/A ACSN
IFNG TLR4 10485906 11489965 11579131 11672593 11777960 11870632 11964313 12032143 12413632 12811837 12818165 14607900 15634932 15644117 15778339 15811952 15814715 16286920 16306937 16424049 16713974 16917499 17016554 17114424 17559085 1825141 18272812 19833085 20038811 20154735 20547845 20819927 21149606 21411734 23508573 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
SPI1 TLR4 10734131 11672593 11964313 12032143 12803886 12811837 16283355 16418395 20510871 23180781 26192618 interaction type,physical association electrophoretic mobility supershift assay ACSN,InnateDB
IRF8 TLR4 10734131 11672593 11875494 11964313 12032143 12417340 12811837 15371411 16243976 16413922 16597464 17404308 17485448 22461508 23180781 23390297 24091328 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
HMGB1 TLR4 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
TLR4 MIF 11672593 11964313 12032143 12803886 12811837 16267105 26192618 interaction type N/A ACSN
TLR4 TRAF3 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 21903422 23180781 23508573 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
LY96 TLR4 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15557191 15694388 15728506 16272300 17056597 22433852 23180781 24097189 physical association affinity chromatography technology,anti tag coimmunoprecipitation,nuclear magnetic resonance,surface plasmon resonance,biotin tag,solid phase assay,surface plasmon resonance array InnateDB
MYD88 TLR4 12646618 12888566 15728506 17126326 17228323 19717524 23180781 9625770 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
TIRAP TLR4 11526399 11544529 12646618 14517278 19717524 21873236 21903422 22139835 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,gst pull down,mammalian protein protein interaction trap InnateDB
RIPK2 TLR4 15691841 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR TLR4 17126326 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TLR5 12794153 23180781 physical association anti tag coimmunoprecipitation InnateDB
TOLLIP TLR4 11441107 11751856 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TLR4 IRAK1 23180781 9625770 physical association anti tag coimmunoprecipitation InnateDB
SFTPA2 TLR4 16754682 23180781 physical association anti tag coimmunoprecipitation InnateDB
SIGIRR TLR4 12925853 15866876 23180781 physical association anti tag coimmunoprecipitation InnateDB
RNF216 TLR4 15107846 23180781 physical association two hybrid InnateDB
TLR1 TLR4 11932926 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOX4 TLR4 15356101 23180781 physical association two hybrid,gst pull down InnateDB
SYK TLR4 14699155 17228323 23180781 physical association anti tag coimmunoprecipitation InnateDB
BTK TLR4 12724322 23180781 physical association two hybrid InnateDB
TLR4 CNPY3 16338228 16849487 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD14 TLR4 11745332 12196527 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
SFTPD TLR4 16834340 18990700 23180781 physical association affinity chromatography technology,solid phase assay InnateDB
SFTPA1 TLR4 16754682 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
TICAM1 TLR4 14519765 19656901 23180781 physical association anti tag coimmunoprecipitation InnateDB
TMED7 TLR4 14517278 14519765 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
HSP90B1 TLR4 11584270 23180781 physical association anti tag coimmunoprecipitation InnateDB
LY86 TLR4 11584270 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TREM1 17098818 23180781 physical association anti tag coimmunoprecipitation InnateDB
F2RL1 TLR4 18622013 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 TLR4 12676954 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEU1 TLR4 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB
MBL2 TLR4 19840833 21383675 23180781 physical association anti tag coimmunoprecipitation,far western blotting,solid phase assay InnateDB
CD36 TLR4 20037584 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELAVL1 TLR4 16990552 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 TLR4 21220427 23180781 physical association anti tag coimmunoprecipitation InnateDB
TP53 TLR4 21483755 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRC TLR4 20379791 23180781 physical association anti tag coimmunoprecipitation InnateDB
UBQLN1 TLR4 21695056 23180781 physical association two hybrid InnateDB
HSPA14 TLR4 21730052 23180781 physical association pull down InnateDB
TLR4 MYD88 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 IRAK4 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TIRAP 21829704 23180781 24265315 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TICAM2 21829704 21903422 22139835 23180781 24265315 physical association anti tag coimmunoprecipitation,mammalian protein protein interaction trap InnateDB
DCN TLR4 22087031 23180781 physical association pull down InnateDB
TLR4 STK11IP 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TLR4 22139835 23180781 physical association mammalian protein protein interaction trap InnateDB
MAL TLR4 22485159 23180781 physical association pull down InnateDB
AHSG TLR4 22842477 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 MYH9 23180781 24489676 physical association anti tag coimmunoprecipitation InnateDB
CIRBP TLR4 23180781 24097189 physical association surface plasmon resonance array InnateDB

Source Target Pmid Interactiontype Methods Database
BCL10 TLR4 20005715 interaction type N/A PSP
MAPK8IP3 TLR4 20005715 interaction type N/A PSP
TOLLIP TLR4 20005715 interaction type N/A PSP
MAPK8IP3 TLR4 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TLR4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TLR4 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1D1 TLR4 18511497 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TLR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TLR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TLR4 10734131 16785240 18971253 20956019 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 TLR4 22208359 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 TLR4 10734131 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 TLR4 16433852 trascriptional regulation,stimulation inferred by curator TFlink
ZNF160 TLR4 19846881 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 TLR4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237CBD TLR4 17660297 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 TLR4 21329689 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000237CBD TLR4 17660297 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 TLR4 21329689 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 TLR4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D TLR4 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000050CCE0 TLR4 23798430 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 TLR4 23437218 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002ECEE4 TLR4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 TLR4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC TLR4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA TLR4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 TLR4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 TLR4 25416803 26222045 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000605E00 TLR4 25416803 27641447 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKD1 TLR4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSPA8 TLR4 25348397 N/A physical interaction ComPPI
TRAF6 TLR4 25348397 N/A physical interaction ComPPI
SERTAD1 TLR4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BTK TLR4 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SYK TLR4 14525934 14699155 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD36 TLR4 20037584 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PPP4C TLR4 25348397 N/A physical interaction ComPPI
SRC TLR4 25348397 N/A physical interaction ComPPI
SMAD3 TLR4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HGS TLR4 25348397 N/A physical interaction ComPPI
BGN TLR4 24234451 24480070 25348397 N/A microscale thermophoresis ComPPI,IntAct
F2RL1 TLR4 18622013 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CAV1 TLR4 25348397 N/A physical interaction ComPPI
HSP90B1 TLR4 11912201 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TIRAP TLR4 11544529 17258210 21829704 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,mammalian protein protein interaction trap,in vivo ComPPI,IntAct
TRAF3 TLR4 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK8IP3 TLR4 12941697 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SIGLEC7 TLR4 24234451 25187624 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
PRKCZ TLR4 25348397 N/A physical interaction ComPPI
HMGB1 TLR4 14525934 16267105 20547845 24234451 25348397 physical association experimental interaction detection,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
IRAK1 TLR4 14525934 25348397 9625770 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EGFR TLR4 17126326 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSPA4 TLR4 25348397 N/A physical interaction ComPPI
IRAK2 TLR4 14525934 25348397 9625770 N/A experimental interaction detection,in vivo ComPPI,HPRD
FCN1 TLR4 24234451 25348397 29150600 N/A enzyme linked immunosorbent assay ComPPI,IntAct
TLR4 TLR1 11932926 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLR4 MYD88 10952994 11743586 14525934 15728506 17126326 17258210 21829704 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TLR4 LY96 15728506 17803912 20547845 24234451 25348397 physical association anti tag coimmunoprecipitation,cross-linking study,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,solid phase assay ComPPI,IntAct
TLR4 TOLLIP 11751856 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLR4 SIGIRR 12925853 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLR4 RNF216 14525934 15107846 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TLR4 TICAM2 14517278 14519765 14525934 14556004 17258210 21829704 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TLR4 DEFB4A 12411706 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLR4 TLR5 12794153 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLR4 RIPK2 14525934 15691841 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLR4 NOX4 14525934 15356101 17064675 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,in vitro,lexa b52 complementation,two hybrid ComPPI,HPRD,IntAct
TLR4 CNPY4 14525934 16338228 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLR4 CD14 12196527 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLR4 STUB1 25348397 N/A physical interaction ComPPI
TLR4 TRIM69 25348397 N/A physical interaction ComPPI
TLR4 TBK1 25348397 N/A physical interaction ComPPI
TLR4 IRAK4 21829704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLR4 STK11IP 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLR4 TICAM1 25348397 N/A physical interaction ComPPI
TLR4 TNFSF9 25348397 N/A physical interaction ComPPI
TLR4 UBQLN1 25348397 N/A physical interaction ComPPI
TLR4 TLR6 20037584 24234451 25348397 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
TLR4 TNC 24234451 25348397 29150600 N/A enzyme linked immunosorbent assay ComPPI,IntAct
TLR4 TNR 24234451 25348397 29150600 N/A enzyme linked immunosorbent assay ComPPI,IntAct
TLR4 TNN 24234451 25348397 29150600 N/A enzyme linked immunosorbent assay ComPPI,IntAct
TLR4 SIGLEC9 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
BCL10 TLR4 14525934 15213237 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SIGLEC5 TLR4 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR4 TLR4 23059983 23155421 24234451 physical association anti tag coimmunoprecipitation,tox-r dimerization assay IntAct
TLR4 EGFR 17126326 27898060 N/A N/A OmniPath
TLR4 MAP3K8 16484370 27898060 N/A N/A OmniPath
TLR4 TICAM1 14519765 18772134 19656901 19898473 25736436 27898060 stimulant N/A OmniPath
TICAM1 TLR4 14519765 18772134 19656901 19898473 25736436 27898060 N/A N/A OmniPath
TLR4 RIPK2 15691841 27898060 N/A N/A OmniPath
TLR4 TICAM2 14517278 14519765 14556004 16410796 17258210 18221795 21829704 21903422 22139835 24265315 25736436 27898060 stimulant N/A OmniPath
TICAM2 TLR4 14517278 14519765 14556004 17258210 18221795 21829704 21903422 22139835 24265315 25736436 27898060 N/A N/A OmniPath
ELAVL1 TLR4 16990552 27898060 N/A N/A OmniPath
TLR4 HSP90B1 11584270 11912201 27898060 N/A N/A OmniPath
TLR4 TLR5 12794153 27898060 N/A N/A OmniPath
TLR4 MYD88 10952994 11743586 12646618 12888566 15107846 15728506 17126326 17228323 17258210 17618294 17635639 18221795 18772134 19378012 19717524 19898473 20048342 21829704 21911421 27898060 9625770 stimulant N/A OmniPath
MYD88 TLR4 10952994 11743586 12646618 12888566 15107846 15728506 17126326 17228323 17258210 17618294 17635639 18221795 18772134 19378012 19717524 19898473 20048342 21829704 21911421 27898060 9625770 N/A N/A OmniPath
TLR4 BTK 12724322 27898060 N/A N/A OmniPath
TLR4 CD14 11745332 12196527 17535871 27898060 N/A N/A OmniPath
CD14 TLR4 11745332 12196527 17535871 27898060 stimulant N/A OmniPath
HMGB1 TLR4 16267105 20547845 27898060 stimulant N/A OmniPath
TLR4 TIRAP 11526399 11544529 12646618 14517278 16410796 17258210 17635639 18221795 19717524 20048342 21829704 21873236 21903422 22139835 24265315 27898060 stimulant N/A OmniPath
TIRAP TLR4 11526399 11544529 12646618 14517278 17258210 17635639 18221795 19717524 20048342 21829704 21873236 21903422 22139835 24265315 27898060 N/A N/A OmniPath
TLR4 IRAK1 17635639 27898060 9625770 N/A N/A OmniPath
TLR4 TRAF3 21903422 27898060 N/A N/A OmniPath
TLR4 MAPKAPK5 24489676 27898060 N/A N/A OmniPath
IRAK4 TLR4 17635639 21220427 21829704 27898060 N/A N/A OmniPath
TLR4 SFTPD 16834340 18990700 27898060 N/A N/A OmniPath
TLR4 LY86 11584270 27898060 N/A N/A OmniPath
TLR4 SFTPA1 16754682 27898060 N/A N/A OmniPath
CIRBP TLR4 24097189 27898060 N/A N/A OmniPath
TLR4 AHSG 22842477 27898060 N/A N/A OmniPath
TREM1 TLR4 17098818 27898060 N/A N/A OmniPath
TLR4 STK11IP 21903422 27898060 N/A N/A OmniPath
F2RL1 TLR4 18622013 27898060 N/A N/A OmniPath
TLR4 UBQLN1 21695056 27898060 N/A N/A OmniPath
TLR4 TMED7 14517278 14519765 27898060 N/A N/A OmniPath
DCN TLR4 22087031 27898060 N/A N/A OmniPath
S100A9 TLR4 17767165 27898060 N/A N/A OmniPath
HSPA14 TLR4 21730052 27898060 stimulant N/A OmniPath
TLR4 SYK 14699155 17228323 27898060 N/A N/A OmniPath
TLR4 SFTPA2 16754682 27898060 N/A N/A OmniPath
TLR4 RNF216 15107846 27898060 N/A N/A OmniPath
TLR4 TOLLIP 11441107 11751856 17635639 27898060 N/A N/A OmniPath
TOLLIP TLR4 11441107 11751856 17635639 27898060 N/A N/A OmniPath
NEU1 TLR4 19430901 27898060 N/A N/A OmniPath
TLR4 MAL 22485159 27898060 N/A N/A OmniPath
TLR4 TLR1 11932926 27898060 N/A N/A OmniPath
TLR4 NOX4 15356101 17064675 27898060 N/A N/A OmniPath
TLR4 SIGIRR 12925853 15866876 27898060 N/A N/A OmniPath
TLR4 LY96 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15175334 15557191 15694388 15728506 16272300 17056597 17535871 17803912 19060881 19252480 22433852 22474354 22532668 24097189 27898060 N/A N/A OmniPath
LY96 TLR4 10359581 11160242 11435474 11593030 11976338 12960171 14607928 15175334 15557191 15694388 15728506 16272300 17056597 17535871 17803912 19060881 19252480 22433852 22474354 22532668 24097189 27898060 N/A N/A OmniPath
TLR4 CNPY3 16338228 16849487 27898060 N/A N/A OmniPath
S100A8 TLR4 17767165 27898060 N/A N/A OmniPath
TLR4 MBL2 19840833 21383675 27898060 N/A N/A OmniPath
MBL2 TLR4 19840833 21383675 27898060 N/A N/A OmniPath
BGN TLR4 16025156 24480070 27898060 N/A N/A OmniPath
ZG16B TLR4 20802527 27898060 N/A N/A OmniPath

Visualization










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