Gene Information gene info

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GENE：TGFB3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TGFB3
FullNmae transforming growth factor beta 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11769
EnsembleID ENSG00000119699
Uniprot P10600

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TGFB3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFB3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFB3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFB3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TGFB3 GO:0001666,GO:0001701,GO:0005114,GO:0005114,GO:0005114,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007179,GO:0007179,GO:0007435,GO:0007565,GO:0008083,GO:0008284,GO:0008285,GO:0009986,GO:0010718,GO:0010718,GO:0010936,GO:0030315,GO:0030512,GO:0030879,GO:0031093,GO:0032570,GO:0032967,GO:0034616,GO:0034713,GO:0034714,GO:0042127,GO:0042476,GO:0042704,GO:0042802,GO:0042802,GO:0043025,GO:0043065,GO:0043231,GO:0043410,GO:0043524,GO:0043627,GO:0044877,GO:0045216,GO:0045893,GO:0045893,GO:0045944,GO:0048286,GO:0048565,GO:0048702,GO:0048839,GO:0050431,GO:0050714,GO:0051491,GO:0051496,GO:0051781,GO:0060325,GO:0060364,GO:0060391,GO:0062009,GO:0062023,GO:0070483,GO:1904706,GO:1905075

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TGFB3 hsa:7043 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04110 Cell cycle - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04218 Cellular senescence - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05140 Leishmaniasis - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05142 Chagas disease - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05144 Malaria - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05146 Amoebiasis - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05152 Tuberculosis - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05161 Hepatitis B - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05210 Colorectal cancer - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05226 Gastric cancer - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
TGFB3 hsa:7043 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TGFB3 TGFBR2 11157754 11382746 11850637 12729750 15017149 16446785 18243111 18988627 21071413 23180781 23331499 8106553 9872992 stimulation,physical association nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography InnateDB,SignaLink,SignaLink
TGFBR1 TGFB3 18243111 23180781 physical association surface plasmon resonance InnateDB
TGFB3 TGFBR1 18243111 23180781 physical association x-ray crystallography InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TGFB3 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TGFB3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC TGFB3 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TGFB3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TGFB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TGFB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TGFB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TGFB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TGFB3 10831118 16611863 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TGFB3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TGFB3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000076995 TGFB3 21169019 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000016D2D4 TGFB3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TGFB3 ACVRL1 25361965 interaction type N/A PTMCode2
ACVRL1 TGFB3 25361965 interaction type N/A PTMCode2
TGFB3 TGFBR2 25361965 interaction type N/A PTMCode2
TGFBR2 TGFB3 25361965 interaction type N/A PTMCode2
TGFBR3 TGFB3 25361965 interaction type N/A PTMCode2
TGFB3 TGFBR3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VASN TGFB3 14525934 15247411 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CHMP2A TGFB3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TGFBR2 TGFB3 11382746 11850637 12729750 14525934 21423151 24234451 25348397 8106553 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,ion exchange chromatography,blue native page,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
ITGAV TGFB3 24234451 25348397 25383667 N/A x-ray crystallography ComPPI,IntAct
CCN2 TGFB3 10457363 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SDC4 TGFB3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TGFB2 TGFB3 25348397 N/A in vivo ComPPI
FMOD TGFB3 14525934 25348397 8093006 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGFBR3 TGFB3 11382746 14525934 21423151 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
ACVRL1 TGFB3 10187774 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TGFB3 ENG 14525934 25348397 9872992 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TGFB3 ELAVL1 25348397 N/A physical interaction ComPPI
TGFB3 CCL20 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TGFB3 TGFBR1 11850637 12060054 12607775 14525934 21423151 24234451 25348397 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,ion exchange chromatography,blue native page,biochemical,surface plasmon resonance array ComPPI,HPRD,IntAct
LTBP3 TGFB3 12062452 14525934 N/A experimental interaction detection HPRD
TGFB3 TGFB3 19073914 21423151 24234451 N/A x-ray crystallography,ion exchange chromatography IntAct
ZMYM3 TGFB3 24234451 30021884 physical association cross-linking study IntAct
TGFB3 TGFBR2 11157754 11382746 11850637 12729750 15017149 16446785 18243111 21423151 27898060 7878020 8106553 9872992 stimulant N/A OmniPath
TGFBR2 TGFB3 11157754 11382746 11850637 12729750 15017149 16446785 18243111 21423151 27898060 7878020 8106553 9872992 inhibition N/A OmniPath
TGFB3 TGFBR1 10187774 11850637 12060054 12607775 18243111 27898060 N/A N/A OmniPath

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