GENE：PDK4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PDK4 |
| FullNmae | pyruvate dehydrogenase kinase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8812 |
| EnsembleID | ENSG00000004799 |
| Uniprot | Q16654 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PDK4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PDK4 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PDK4 | anoikis | 29505302 | In addition, inhibition of glycolysis by CEMIP-mediated PDK4 down-regulation impaired the migration and invasion of anoikis-resistant PCa cells by attenuating MMP2 and VEGF expressions. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PDK4 | GO:0004672,GO:0004740,GO:0004740,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006006,GO:0006468,GO:0006885,GO:0008286,GO:0009267,GO:0010510,GO:0010510,GO:0010565,GO:0010906,GO:0010906,GO:0016310,GO:0042304,GO:0042593,GO:0042594,GO:0045124,GO:0046320,GO:0071398,GO:0072593,GO:2000811 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PDK4 | hsa:5166 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PDK4 | DLD | 26192618 | interaction type | N/A | ACSN |
| ESRRA | PDK4 | 16314495 18046414 18048642 26192618 | interaction type | N/A | ACSN |
| PPARGC1A | PDK4 | 16314495 18046414 18048642 26192618 | interaction type | N/A | ACSN |
| PDK4 | E2F1 | 21625432 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | PDK4 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | PDK4 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | PDK4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PDK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PDK4 | 21625432 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | PDK4 | 21625432 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARA | PDK4 | 15955060 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARD | PDK4 | 15955060 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | PDK4 | 21625432 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | PDK4 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | PDK4 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001CC379 | PDK4 | 25416803 27396327 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00003380CC | PDK4 | 25416803 26506419 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PLEKHF2 | PDK4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PDHA1 | PDK4 | 11485553 11486000 12676647 14525934 24234451 25348397 27505672 | phosphorylation reaction | experimental interaction detection,protein kinase assay,in vitro | ComPPI,HPRD,IntAct |
| TRIM63 | PDK4 | 14525934 18468620 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| PDK2 | PDK4 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | PDK4 | 11978179 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PDK1 | PDK4 | 25348397 | N/A | physical interaction | ComPPI |
| PDK3 | PDK4 | 25348397 | N/A | physical interaction | ComPPI |
| PDK4 | NARS2 | 25348397 | N/A | physical interaction | ComPPI |
| PDK4 | PDK4 | 11978179 14525934 | N/A | experimental interaction detection | HPRD |
| THRAP3 | PDK4 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PDK4 | PLEK | 27898060 7559487 8615792 | N/A | N/A | OmniPath |
| PDK4 | PDHA2 | 14966024 27898060 | inhibition | N/A | OmniPath |
| PDK4 | PDHA1 | 11485553 11486000 12676647 15302935 16436377 17081983 17474719 17487921 18088087 18212344 18220336 18691976 18767875 19081061 19415658 19690332 20166139 27898060 7273851 | inhibition | N/A | OmniPath |