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GENE：TNFRSF10A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFRSF10A
FullNmae TNF receptor superfamily member 10a
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11904
EnsembleID ENSG00000104689
Uniprot O00220

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFRSF10A necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF10A necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TNFRSF10A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF10A apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNFRSF10A GO:0002020,GO:0005035,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006915,GO:0007165,GO:0007250,GO:0008625,GO:0009986,GO:0009986,GO:0036462,GO:0036462,GO:0036462,GO:0038023,GO:0042802,GO:0043065,GO:0045121,GO:0045569,GO:0071260,GO:0097191

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFRSF10A hsa:8797 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa04210 Apoptosis - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa04217 Necroptosis - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa05132 Salmonella infection - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa05164 Influenza A - Homo sapiens (human)
TNFRSF10A hsa:8797 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF10A TNFSF10 10894161 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10A FADD 10894161 15452120 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TNFRSF10A CASP8 10894161 17047155 17898872 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TNFRSF10A 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
BCL10 TNFRSF10A 20005715 interaction type N/A PSP
FADD TNFRSF10A 20005715 interaction type N/A PSP
RASSF1 TNFRSF10A 20005715 interaction type N/A PSP
TRADD TNFRSF10A 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR TNFRSF10A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TNFRSF10A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TNFRSF10A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GLI3 TNFRSF10A 20562908 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 TNFRSF10A 11313989 15289308 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TNFRSF10A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TNFRSF10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 TNFRSF10A 18408217 trascriptional regulation,stimulation inferred by curator TFlink
JUN TNFRSF10A 12082627 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TNFRSF10A 21243522 trascriptional regulation,stimulation inferred by curator TFlink
RELA TNFRSF10A 21243522 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 TNFRSF10A N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB TNFRSF10A N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 TNFRSF10A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 TNFRSF10A N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 TNFRSF10A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS000016FF9C TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 TNFRSF10A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 TNFRSF10A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B TNFRSF10A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 TNFRSF10A 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00000600E6 TNFRSF10A 25416803 28410209 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E0524 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C85B2 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000243FF1 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDAA TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000355E82 TNFRSF10A 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CD4 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A CD4 25361965 interaction type N/A PTMCode2
TNFRSF10A TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A RIPK1 25361965 interaction type N/A PTMCode2
RIPK1 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A CASP10 25361965 interaction type N/A PTMCode2
CASP10 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A FADD 25361965 interaction type N/A PTMCode2
FADD TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A CFLAR 25361965 interaction type N/A PTMCode2
CFLAR TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A TRADD 25361965 interaction type N/A PTMCode2
TRADD TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A DAP3 25361965 interaction type N/A PTMCode2
DAP3 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A ARAP1 25361965 interaction type N/A PTMCode2
ARAP1 TNFRSF10A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MOAP1 TNFRSF10A 14525934 15949439 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CD4 TNFRSF10A 14525934 25348397 27898060 7650480 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CBL TNFRSF10A 25348397 N/A physical interaction ComPPI
BTK TNFRSF10A 14525934 15007095 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CUL3 TNFRSF10A 19427028 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DAP3 TNFRSF10A 11376335 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
IFNAR1 TNFRSF10A 25348397 N/A physical interaction ComPPI
UBB TNFRSF10A 25348397 N/A physical interaction ComPPI
CDC6 TNFRSF10A 25348397 N/A physical interaction ComPPI
CASP8 TNFRSF10A 12218097 14525934 17047155 19427028 20103630 21785459 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
SQSTM1 TNFRSF10A 19427028 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FADD TNFRSF10A 14525934 19427028 21785459 24234451 25348397 9430227 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SDCBP TNFRSF10A 25348397 N/A physical interaction ComPPI
TRAF2 TNFRSF10A 25348397 N/A physical interaction ComPPI
RASSF1 TNFRSF10A 14525934 15949439 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP10 TNFRSF10A 19427028 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK1 TNFRSF10A 14525934 25348397 9430227 N/A experimental interaction detection,in vivo ComPPI,HPRD
MADD TNFRSF10A 14525934 15208670 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CFLAR TNFRSF10A 19427028 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COL2A1 TNFRSF10A 14525934 25348397 27898060 9811967 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
TRIM25 TNFRSF10A 25348397 N/A physical interaction ComPPI
TRADD TNFRSF10A 14525934 25348397 9430227 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1 TNFRSF10A 25348397 N/A physical interaction ComPPI
BCL10 TNFRSF10A 10400625 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR1A TNFRSF10A 25348397 N/A physical interaction ComPPI
UGCG TNFRSF10A 25348397 N/A physical interaction ComPPI
MARCHF8 TNFRSF10A 25348397 N/A physical interaction ComPPI
TNFRSF10A TNFSF10 10549288 10894160 14525934 19427028 20103630 24234451 25348397 9082980 9325248 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TNFRSF10A TNFRSF10B 14525934 16319225 19427028 24234451 25348397 9430228 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TNFRSF10A TNFRSF10D 14525934 16319225 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFRSF10A ALDH3B1 25348397 N/A physical interaction ComPPI
TNFRSF10A FGFR4 25348397 N/A physical interaction ComPPI
TNFRSF10A LSS 25348397 N/A physical interaction ComPPI
TNFRSF10A KCNT2 25348397 N/A physical interaction ComPPI
TNFRSF10A TMEM94 25348397 N/A physical interaction ComPPI
TNFRSF10A FBXO11 25348397 N/A physical interaction ComPPI
TNFRSF10A LAPTM4B 25348397 N/A physical interaction ComPPI
TNFRSF10A SLC12A4 25348397 N/A physical interaction ComPPI
TNFRSF10A ABCD4 25348397 N/A physical interaction ComPPI
TNFRSF10A MAP1LC3B2 25348397 N/A physical interaction ComPPI
TNFRSF10A LRP10 25348397 N/A physical interaction ComPPI
TNFRSF10A CARNMT1 25348397 N/A physical interaction ComPPI
TNFRSF10A ST7L 25348397 N/A physical interaction ComPPI
TNFRSF10A RNF149 25348397 N/A physical interaction ComPPI
TNFRSF10A BTN2A2 25348397 N/A physical interaction ComPPI
TNFRSF10A ATG9A 25348397 N/A physical interaction ComPPI
TNFRSF10A ERMP1 25348397 N/A physical interaction ComPPI
TNFRSF10A S100A10 25348397 N/A physical interaction ComPPI
TNFRSF10A PI4K2A 25348397 N/A physical interaction ComPPI
TNFRSF10A CD320 25348397 N/A physical interaction ComPPI
TNFRSF10A MFAP3 25348397 N/A physical interaction ComPPI
TNFRSF10A IL4R 25348397 N/A physical interaction ComPPI
TNFRSF10A DDRGK1 25348397 N/A physical interaction ComPPI
TNFRSF10A ACVR2A 25348397 N/A physical interaction ComPPI
TNFRSF10A ARAP1 18165900 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct
TNFRSF10A OTUD7B 19427028 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TNFRSF10A PARK7 21785459 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNFRSF10A TNFRSF10A 14525934 16319225 N/A experimental interaction detection HPRD
TNFRSF10A AGFG1 10958661 27898060 9430227 N/A N/A OmniPath
TNFRSF10A FADD 10894161 11376335 12920112 14585074 15280356 15388581 15452120 16980609 19427028 21272366 23142077 27898060 9430227 9430228 stimulant N/A OmniPath
FADD TNFRSF10A 10894161 11376335 12920112 15280356 15388581 15452120 16980609 19427028 21272366 23142077 27898060 9430227 9430228 N/A N/A OmniPath
TNFRSF10A TNFRSF10B 15388581 16319225 16980609 19427028 27898060 9430228 stimulant N/A OmniPath
TP53 TNFRSF10A 11382926 27898060 stimulant N/A OmniPath
TNFRSF10A TRADD 27898060 9430227 9430228 stimulant N/A OmniPath
TNFRSF10A CASP8 10894161 12218097 15280356 15388581 17047155 17898872 19343040 19427028 21785459 22421964 23142077 27898060 9325248 stimulant N/A OmniPath
TNFSF10 TNFRSF10A 10549288 10894161 12628743 14585074 15538968 15766588 20103630 27898060 9082980 9325248 stimulant N/A OmniPath
TNFRSF10A RIPK1 27898060 9430227 stimulant N/A OmniPath

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