GENE：PIK3CA
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PIK3CA |
| FullNmae | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8975 |
| EnsembleID | ENSG00000121879 |
| Uniprot | P42336 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PIK3CA | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIK3CA | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
| PIK3CA | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIK3CA | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIK3CA | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIK3CA | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| PIK3CA | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIK3CA | anoikis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PIK3CA | GO:0001525,GO:0001889,GO:0001944,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005943,GO:0005943,GO:0005943,GO:0005944,GO:0006006,GO:0006909,GO:0007173,GO:0008286,GO:0010592,GO:0010629,GO:0014704,GO:0014823,GO:0014870,GO:0016242,GO:0016301,GO:0016303,GO:0016303,GO:0016303,GO:0016303,GO:0016310,GO:0016477,GO:0030027,GO:0030036,GO:0030168,GO:0030295,GO:0030835,GO:0031295,GO:0032008,GO:0032869,GO:0033138,GO:0035005,GO:0035994,GO:0036092,GO:0038084,GO:0040014,GO:0043201,GO:0043276,GO:0043457,GO:0043491,GO:0043491,GO:0043491,GO:0043524,GO:0043542,GO:0043560,GO:0044029,GO:0046854,GO:0046934,GO:0046934,GO:0048009,GO:0048015,GO:0048471,GO:0048661,GO:0050852,GO:0051897,GO:0055119,GO:0060048,GO:0060612,GO:0071333,GO:0071464,GO:0071514,GO:0071548,GO:0086003,GO:0097009,GO:0106310,GO:0110053,GO:1903544,GO:1905477,GO:2000270,GO:2000811,GO:2000811 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PIK3CA | hsa:5290 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04931 | Insulin resistance - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05162 | Measles - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05214 | Glioma - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| PIK3CA | hsa:5290 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HRAS | PIK3CA | 23180781 9113989 9150145 | physical association | gst pull down | InnateDB |
| TICAM1 | PIK3CA | 15940673 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3R1 | PIK3CA | 11526404 12147247 14729945 15932879 23180781 | phosphorylation reaction,physical association | anti tag coimmunoprecipitation,gst pull down | InnateDB |
| PIK3CA | ESR1 | 11029009 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CTNNB1 | PIK3CA | 16219695 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3R2 | PIK3CA | 12147247 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| APPL1 | PIK3CA | 10490823 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3CA | PRDM1 | 20421211 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3CA | PIK3CA | 11160134 18721898 26467481 | interaction type,up-regulates,down-regulates activity | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| APPL1 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| IRS1 | PIK3CA | 20005715 | interaction type | N/A | PSP,SignaLink |
| IRS2 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| IRS4 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| NEDD9 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| PIK3R1 | PIK3CA | 16043515 18988627 20005715 7929193 | interaction type | N/A | PSP,SignaLink |
| SLC9A3R1 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| SQSTM1 | PIK3CA | 20005715 | interaction type | N/A | PSP |
| YWHAH | PIK3CA | 20005715 | interaction type | N/A | PSP |
| NEDD9 | PIK3CA | 18624398 20005715 21071413 | N/A | N/A | SignaLink |
| IRS4 | PIK3CA | 11912194 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| SQSTM1 | PIK3CA | 18624398 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| IRS2 | PIK3CA | 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PIK3CA | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PIK3CA | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PIK3CA | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PIK3CA | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PIK3CA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXO3 | PIK3CA | 19299143 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | PIK3CA | 23060442 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR1 | PIK3CA | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PIK3CA | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000521626 | PIK3CA | 23238785 | rna interference,inhibition | western blot | miRSponge |
| URS0000521626 | PIK3CA | 23233531 23238785 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | PIK3CA | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002075FA | PIK3CA | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000ED600 | PIK3CA | 24440701 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000338542 | PIK3CA | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001496AE | PIK3CA | 25416803 26559013 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004DA9DB | PIK3CA | 24996183 25416803 26617776 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000023BE29 | PIK3CA | 24158791 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000508C13 | PIK3CA | 25416803 25591738 | mrna cleavage,inhibition | array technology,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000006FDD4 | PIK3CA | 25416803 26058752 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004AC389 | PIK3CA | 25416803 25896413 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIK3CA | RPS6KB1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PIK3CA | TPM1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PIK3CA | PIK3R1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PIK3CA | CBL | 25361965 | interaction type | N/A | PTMCode2 |
| CBL | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | ERBB3 | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB3 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3R1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | GNA11 | 25361965 | interaction type | N/A | PTMCode2 |
| GNA11 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | APPL1 | 25361965 | interaction type | N/A | PTMCode2 |
| APPL1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | IRS1 | 25361965 | interaction type | N/A | PTMCode2 |
| IRS1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | HRAS | 25361965 | interaction type | N/A | PTMCode2 |
| HRAS | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | PRKCD | 25361965 | interaction type | N/A | PTMCode2 |
| PRKCD | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| LCK | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | PTEN | 25361965 | interaction type | N/A | PTMCode2 |
| PTEN | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | IRS4 | 25361965 | interaction type | N/A | PTMCode2 |
| IRS4 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | IRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| IRS2 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | SH3KBP1 | 25361965 | interaction type | N/A | PTMCode2 |
| SH3KBP1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | SLC9A3R2 | 25361965 | interaction type | N/A | PTMCode2 |
| SLC9A3R2 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KB1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| CSF1R | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | CSF1R | 25361965 | interaction type | N/A | PTMCode2 |
| SLC9A3R1 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | SLC9A3R1 | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3R2 | PIK3CA | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CA | PIK3R2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIK3R2 | PIK3CA | 19380743 22402981 24234451 25253337 25348397 26496610 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| DPY30 | PIK3CA | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FTL | PIK3CA | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FBP2 | PIK3CA | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| SH3KBP1 | PIK3CA | 10921882 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| KRAS | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| PCBP1 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| STAT1 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| AMBP | PIK3CA | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RAC1 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| CRK | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| BEX1 | PIK3CA | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| APPL1 | PIK3CA | 10490823 14525934 24234451 25241761 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid | ComPPI,HPRD,IntAct |
| CBL | PIK3CA | 19380743 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| HRAS | PIK3CA | 14525934 24234451 24412244 25348397 9150145 | physical association | two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo | ComPPI,HPRD,IntAct |
| ARHGEF1 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| KIT | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R1 | PIK3CA | 14525934 16043515 19574958 19805105 20018188 20713702 22402981 23643389 24234451 25253337 25348397 26496610 7929193 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,phosphotransferase assay | ComPPI,HPRD,IntAct |
| LCK | PIK3CA | 14525934 25348397 8020561 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| NOTCH1 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| ATR | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| PRKCD | PIK3CA | 11676480 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GRB2 | PIK3CA | 21706016 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NEDD9 | PIK3CA | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SMAD2 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| SMAD3 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| PDGFRB | PIK3CA | 14525934 25348397 8702949 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD28 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| UBTF | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| IRS2 | PIK3CA | 14525934 25348397 9113989 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| IRS4 | PIK3CA | 11912194 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PIK3CA | GNAQ | 12704201 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PIK3CA | PIK3R3 | 14525934 22402981 24234451 25348397 25814554 26496610 9415396 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid | ComPPI,HPRD,IntAct |
| PIK3CA | MRAS | 10803462 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PIK3CA | RASD2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PIK3CA | GABRB1 | 11606067 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PIK3CA | APLP2 | 10490823 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PIK3CA | IL3 | 14525934 25348397 9113989 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PIK3CA | TICAM1 | 14525934 15940673 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PIK3CA | RPS6KB1 | 11279232 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| PIK3CA | GRIN2B | 10620012 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| PIK3CA | NRAS | 14525934 25348397 7820549 8665852 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| PIK3CA | RASGRP3 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | ADAP1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | DGKZ | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | IRS1 | 16150444 23643389 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| PIK3CA | GSN | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | YWHAH | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | SGK1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | SQSTM1 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | ATP5IF1 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | VARS2 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | DDX5 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | DNAJB6 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | ITIH1 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | RPS20 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | UFD1 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3CA | TNFRSF1A | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | FASLG | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | CD40 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | ESR1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | AKT1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | NTRK1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | BEX2 | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | IL13RA2 | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | IL24 | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | PSMC3IP | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | TNFSF13 | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | UMPS | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | HDAC1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PIK3CA | TSPAN14 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | ERBB3 | 19411071 24189400 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| PIK3CA | PDK1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | CYTH3 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | CYTH2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | GNB1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | HAVCR2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | FLRT1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | IL20RA | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | SUN2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | TMEM52B | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | MANSC1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | ZDHHC1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | NLGN3 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | RNF19B | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | DEFA5 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | PDGFRA | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | PTTG1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | PTTG2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | CSF1R | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | DERL1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | CSF2RB | 25348397 | N/A | phosphorylation reaction,protein kinase assay | ComPPI |
| PIK3CA | DLG1 | 24234451 25253337 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PIK3CA | PTK2 | 22402981 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PIK3CA | FANCC | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| PIK3CA | GALNT12 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| PIK3CA | MAP2K1 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| PIK3CA | SFRP4 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| PIK3CA | TMOD1 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NEDD4L | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | PIK3CA | 25348397 | N/A | physical interaction | ComPPI |
| THRSP | PIK3CA | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3CA | PIK3CA | 23643389 24234451 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation | IntAct |
| PIK3CA | TPM1 | 16094730 27898060 | N/A | N/A | OmniPath |
| SRC | PIK3CA | 12750372 27898060 | stimulant | N/A | OmniPath |
| PIK3R2 | PIK3CA | 12147247 19380743 23604317 26496610 27898060 | N/A | N/A | OmniPath |
| NTRK1 | PIK3CA | 27898060 8226808 | inhibition,stimulant | N/A | OmniPath |
| ITGB4 | PIK3CA | 11733063 12867433 27898060 7721947 8143784 9428518 | stimulant | N/A | OmniPath |
| TICAM1 | PIK3CA | 15940673 27898060 | N/A | N/A | OmniPath |
| HRAS | PIK3CA | 10783161 14724584 24412244 27898060 8052307 8665852 9113989 9150145 | stimulant | N/A | OmniPath |
| LAT | PIK3CA | 11368773 27898060 | stimulant | N/A | OmniPath |
| ESR1 | PIK3CA | 11029009 24051437 27898060 | N/A | N/A | OmniPath |
| PIK3CA | AKT1 | 19573809 27898060 | stimulant | N/A | OmniPath |
| IRS1 | PIK3CA | 11160134 12933652 1380456 1381348 14511371 16150444 16354680 20966354 23604317 23643389 27898060 9374521 | stimulant | N/A | OmniPath |
| PIK3CA | IRS1 | 11160134 12933652 14511371 16150444 16354680 20966354 23604317 23643389 27898060 | inhibition | N/A | OmniPath |
| GNA11 | PIK3CA | 15313914 27898060 | inhibition,stimulant | N/A | OmniPath |
| PIK3AP1 | PIK3CA | 22187458 27898060 | stimulant | N/A | OmniPath |
| GAB1 | PIK3CA | 11043767 27898060 8596638 | stimulant | N/A | OmniPath |
| IRS2 | PIK3CA | 12933652 22810696 25879670 27898060 9113989 9374521 | stimulant | N/A | OmniPath |
| SHC1 | PIK3CA | 27898060 7537361 | stimulant | N/A | OmniPath |
| PIK3R1 | PIK3CA | 11526404 12147247 14729945 15377662 15932879 16043515 16135792 19574958 19805105 20018188 20713702 22402981 23643389 26496610 27898060 7929193 | stimulant | N/A | OmniPath |
| PIK3CA | PIK3R1 | 11526404 12147247 14729945 15377662 15932879 16043515 16135792 19574958 19805105 20018188 20713702 22402981 23643389 26496610 27898060 7929193 | N/A | N/A | OmniPath |
| TNF | PIK3CA | 10485710 27898060 | stimulant | N/A | OmniPath |
| ERBB2 | PIK3CA | 27898060 8026468 | stimulant | N/A | OmniPath |
| GRB10 | PIK3CA | 12783867 27898060 | stimulant | N/A | OmniPath |
| NRAS | PIK3CA | 21779497 27898060 7820549 8052307 8665852 9150145 | stimulant | N/A | OmniPath |
| ERBB4 | PIK3CA | 16729043 27898060 | stimulant | N/A | OmniPath |
| PTPN11 | PIK3CA | 27898060 7522233 | stimulant | N/A | OmniPath |
| ERBB3 | PIK3CA | 16729043 19411071 27898060 | stimulant | N/A | OmniPath |
| PIK3CA | MTOR | 18721898 27898060 | stimulant | N/A | OmniPath |
| PIK3CA | RPS6KB1 | 11279232 18669648 20068231 27898060 | stimulant | N/A | OmniPath |
| CBLB | PIK3CA | 11087752 27898060 | inhibition | N/A | OmniPath |
| DAB2IP | PIK3CA | 27858941 27898060 | inhibition | N/A | OmniPath |
| APPL1 | PIK3CA | 10490823 25241761 27898060 | N/A | N/A | OmniPath |
| KRAS | PIK3CA | 21779497 27898060 | stimulant | N/A | OmniPath |
| GAB2 | PIK3CA | 24737791 27898060 | stimulant | N/A | OmniPath |
| GNGT1 | PIK3CA | 16537363 17419683 27898060 | stimulant | N/A | OmniPath |
| PIK3R3 | PIK3CA | 25814554 26496610 27898060 9415396 | stimulant | N/A | OmniPath |
| GNG12 | PIK3CA | 16293724 27898060 | stimulant | N/A | OmniPath |
| GNG3 | PIK3CA | 16537363 17419683 27898060 | stimulant | N/A | OmniPath |
| GNB1 | PIK3CA | 16537363 27898060 | stimulant | N/A | OmniPath |
| GNB3 | PIK3CA | 14668344 27898060 | stimulant | N/A | OmniPath |
| GNG2 | PIK3CA | 16537363 17419683 27898060 | stimulant | N/A | OmniPath |