Gene Information gene info

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GENE：PTK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTK2
FullNmae protein tyrosine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9611
EnsembleID ENSG00000169398
Uniprot Q05397

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTK2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTK2 apoptosis 36060520 PTK2 and mt2a genes contribute to the cell cycle during proliferation and apoptosis, respectively. retulator signature
PTK2 anoikis 27495308 Both HIF1A and PTK2 were indispensable for SMARCE1-mediated protection against anoikis by promoting activation of ERK and AKT pathways while suppressing the expression of pro-apoptotic BIM protein. retulator signature

Go Annotation:

GeneSymbol Go id
PTK2 GO:0001525,GO:0001525,GO:0001725,GO:0001890,GO:0001932,GO:0001934,GO:0003007,GO:0003779,GO:0004713,GO:0004713,GO:0004715,GO:0004715,GO:0004725,GO:0005178,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005925,GO:0005938,GO:0006468,GO:0007172,GO:0007173,GO:0007179,GO:0007229,GO:0007229,GO:0007229,GO:0007411,GO:0008284,GO:0008284,GO:0008360,GO:0008432,GO:0010594,GO:0010632,GO:0010634,GO:0010718,GO:0010759,GO:0010763,GO:0016477,GO:0018108,GO:0019901,GO:0019903,GO:0022408,GO:0030010,GO:0030155,GO:0030335,GO:0030335,GO:0033628,GO:0035995,GO:0036064,GO:0038007,GO:0038096,GO:0042127,GO:0042169,GO:0043066,GO:0043087,GO:0043197,GO:0043231,GO:0045667,GO:0045860,GO:0046777,GO:0048010,GO:0048013,GO:0048471,GO:0048870,GO:0051493,GO:0051893,GO:0051893,GO:0051897,GO:0051897,GO:0060396,GO:0090303,GO:0120041,GO:0140677,GO:1900024,GO:2000060,GO:2000811

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTK2 hsa:5747 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04148 Efferocytosis - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04360 Axon guidance - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04510 Focal adhesion - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PTK2 hsa:5747 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05131 Shigellosis - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05135 Yersinia infection - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05146 Amoebiasis - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
PTK2 hsa:5747 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PKD1 PTK2 11113628 23180781 physical association cosedimentation through density gradient InnateDB
PTK2 PXN 11113628 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTK2 PAK1 11278553 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD36 PTK2 20037584 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 PTK2 12221124 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTK2 SHC1 10749687 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTK2 GRB2 10749687 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTK2 ITGB1 19889638 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTK2 LYN 23180781 9169439 physical association affinity technology InnateDB
PTK2 SELE 23180781 8609175 physical association anti tag coimmunoprecipitation InnateDB
PTK2 SLC9A3R1 15161943 23180781 physical association pull down InnateDB
SRPK1 PTK2 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB
NCK2 PTK2 11950595 23331499 stimulation N/A SignaLink,SignaLink
FGR PTK2 10593973 12495636 23109003 7529876 9148935 chemical activation reaction N/A SignaLink
HCK PTK2 10593973 12495636 23109003 7529876 9148935 chemical activation reaction N/A SignaLink
LYN PTK2 10593973 12495636 23109003 7529876 9148935 chemical activation reaction N/A SignaLink
SRC PTK2 10593973 12495636 23109003 7529876 9148935 chemical activation reaction N/A SignaLink
PTEN PTK2 10400703 23109003 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BCAR1 PTK2 20005715 interaction type N/A PSP
CRK PTK2 20005715 interaction type N/A PSP
CSPG4 PTK2 20005715 interaction type N/A PSP,SignaLink
EFS PTK2 20005715 interaction type N/A PSP,SignaLink
GRB2 PTK2 12558988 20005715 21071413 interaction type N/A PSP,SignaLink
GRB7 PTK2 20005715 interaction type N/A PSP,SignaLink
IRS1 PTK2 20005715 21071413 9822703 interaction type N/A PSP,SignaLink
LPXN PTK2 20005715 interaction type N/A PSP
MAPK8IP3 PTK2 12226752 20005715 21071413 interaction type N/A PSP,SignaLink
NCK1 PTK2 20005715 interaction type N/A PSP,SignaLink
NCK2 PTK2 20005715 interaction type N/A PSP,SignaLink
NEDD9 PTK2 20005715 21071413 8668148 interaction type N/A PSP,SignaLink
PIK3R1 PTK2 20005715 interaction type N/A PSP
PKD1 PTK2 20005715 interaction type N/A PSP,SignaLink
PXN PTK2 20005715 interaction type N/A PSP
SHC1 PTK2 20005715 interaction type N/A PSP,SignaLink
SOCS2 PTK2 20005715 interaction type N/A PSP
SORBS1 PTK2 20005715 interaction type N/A PSP,SignaLink
TGFB1I1 PTK2 20005715 interaction type N/A PSP
TRIP6 PTK2 20005715 interaction type N/A PSP,SignaLink
TSC1 PTK2 20005715 interaction type N/A PSP
BCAR1 PTK2 10753828 12135674 12615911 20005715 21071413 N/A N/A SignaLink
SOCS2 PTK2 16189514 20005715 21071413 N/A N/A SignaLink
CRK PTK2 12615911 20005715 20005715 21071413 N/A N/A SignaLink
TSC1 PTK2 17043358 20005715 20005715 21071413 N/A N/A SignaLink
PIK3R1 PTK2 20005715 20005715 21071413 7537275 7537275 N/A N/A SignaLink
LPXN PTK2 20005715 20005715 21071413 21900206 N/A N/A SignaLink
PXN PTK2 10753828 11919182 11919182 20005715 20005715 21071413 9422762 9442086 N/A N/A SignaLink
TGFB1I1 PTK2 20005715 20005715 21071413 21900206 9422762 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PTK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PTK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PTK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PTK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 PTK2 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PTK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PTK2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000367985 PTK2 18381414 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000367985 PTK2 18381414 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D PTK2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000000B1C9 PTK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 PTK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019F055 PTK2 24699721 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001EE123 PTK2 25416803 26944318 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PDGFRB PTK2 22135298 phosphorylation N/A PhosphoSite
YES1 PTK2 22135298 phosphorylation N/A PhosphoSite
SRC PTK2 22135298 phosphorylation N/A PhosphoSite
PTK2B PTK2 22135298 phosphorylation N/A PhosphoSite
FGR PTK2 22135298 phosphorylation N/A PhosphoSite
BMX PTK2 22135298 phosphorylation N/A PhosphoSite
MET PTK2 22135298 phosphorylation N/A PhosphoSite
CDK5 PTK2 22135298 phosphorylation N/A PhosphoSite
ROCK1 PTK2 22135298 phosphorylation N/A PhosphoSite
PTK2 CDCP1 22135298 phosphorylation N/A PhosphoSite
PTK2 ITGB7 22135298 phosphorylation N/A PhosphoSite
PTK2 NANOG 22135298 phosphorylation N/A PhosphoSite
PTK2 BECN1 22135298 phosphorylation N/A PhosphoSite
PTK2 PTK2 22135298 phosphorylation N/A PhosphoSite
PTK2 ACTN1 22135298 phosphorylation N/A PhosphoSite
PTK2 SH3GL1 22135298 phosphorylation N/A PhosphoSite
PTK2 RAC1 22135298 phosphorylation N/A PhosphoSite
PTK2 RET 22135298 phosphorylation N/A PhosphoSite
PTK2 GIT1 22135298 phosphorylation N/A PhosphoSite
PTK2 GRB7 22135298 phosphorylation N/A PhosphoSite
PTK2 TRIO 22135298 phosphorylation N/A PhosphoSite
PTK2 BCAR1 22135298 phosphorylation N/A PhosphoSite
EGFR PTK2 22135298 phosphorylation N/A PhosphoSite
RET PTK2 22135298 phosphorylation N/A PhosphoSite
AKT1 PTK2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NCK2 PTK2 25348397 N/A physical interaction ComPPI
PIK3R2 PTK2 22402981 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SOCS3 PTK2 16007195 18031698 25348397 25416956 27898060 N/A physical interaction ComPPI,OmniPath
YES1 PTK2 23397142 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
DEF6 PTK2 25348397 N/A physical interaction ComPPI
FBP1 PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SH3KBP1 PTK2 25348397 N/A physical interaction ComPPI
STAT1 PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ITGB5 PTK2 25348397 N/A physical interaction ComPPI
PPP1CB PTK2 25348397 N/A physical interaction ComPPI
PTPN6 PTK2 25348397 N/A two hybrid,physical interaction ComPPI
RAC1 PTK2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSP90AB1 PTK2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CRK PTK2 24234451 25348397 25814554 7561682 physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
GRB7 PTK2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
ERBB2 PTK2 21034468 24234451 25241761 25348397 physical association coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
CBL PTK2 25348397 N/A physical interaction ComPPI
SYK PTK2 25348397 N/A physical interaction ComPPI
CD36 PTK2 20037584 24234451 25348397 association pull down ComPPI,IntAct
LYN PTK2 11389892 24234451 25348397 25814554 physical association coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
PIK3R1 PTK2 25348397 N/A physical interaction ComPPI
PTPN11 PTK2 25348397 N/A physical interaction ComPPI
SRC PTK2 16291744 16966330 17525734 21034468 22402981 23065768 24234451 25241761 25348397 25814554 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction,two hybrid array,proximity ligation assay ComPPI,IntAct
CRKL PTK2 23397142 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
FLT1 PTK2 23397142 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
SHC1 PTK2 25348397 N/A physical interaction ComPPI
NCK1 PTK2 25348397 N/A physical interaction ComPPI
GRB2 PTK2 21900206 24234451 25348397 7597091 association,physical association two hybrid,pull down,physical interaction ComPPI,IntAct
NEDD9 PTK2 25348397 N/A physical interaction ComPPI
PIAS1 PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ITGB1 PTK2 25348397 N/A physical interaction ComPPI
ITGAV PTK2 23397142 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PRKG1 PTK2 25348397 N/A physical interaction ComPPI
CIB1 PTK2 25348397 N/A physical interaction ComPPI
GSK3B PTK2 25348397 N/A physical interaction ComPPI
GAPDH PTK2 25348397 N/A physical interaction ComPPI
PIK3CA PTK2 22402981 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3R3 PTK2 22402981 24234451 25348397 25814554 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
HSP90AA1 PTK2 25348397 N/A physical interaction ComPPI
NTRK1 PTK2 25348397 N/A physical interaction ComPPI
GIT1 PTK2 25348397 N/A physical interaction ComPPI
APC PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CDH5 PTK2 25348397 N/A physical interaction ComPPI
PKD1 PTK2 25348397 N/A physical interaction ComPPI
SERPINB2 PTK2 25348397 N/A physical interaction ComPPI
PTAFR PTK2 25348397 N/A physical interaction ComPPI
ITGB3 PTK2 25348397 N/A physical interaction ComPPI
TLN1 PTK2 25348397 N/A physical interaction ComPPI
PARP1 PTK2 25348397 N/A physical interaction ComPPI
SOCS2 PTK2 25348397 N/A physical interaction ComPPI
PPP1CA PTK2 25348397 N/A physical interaction ComPPI
MAPK8IP3 PTK2 25348397 N/A physical interaction ComPPI
EPHA2 PTK2 10655584 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
PXN PTK2 21034468 21741599 22270917 24234451 25348397 7561682 9756887 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,far western blotting,pull down,physical interaction,fluorescence microscopy,confocal microscopy ComPPI,IntAct
TRIP6 PTK2 25348397 N/A physical interaction ComPPI
HNRNPL PTK2 25348397 N/A physical interaction ComPPI
IQGAP1 PTK2 25348397 N/A physical interaction ComPPI
PKM PTK2 25348397 N/A protein kinase assay ComPPI
DOCK1 PTK2 25348397 N/A physical interaction ComPPI
RBSN PTK2 25348397 N/A physical interaction ComPPI
TSC2 PTK2 25348397 N/A physical interaction ComPPI
SELE PTK2 25348397 N/A physical interaction ComPPI
CCNA1 PTK2 17353931 24234451 25241761 25348397 physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
CSK PTK2 25348397 N/A physical interaction ComPPI
SAE1 PTK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DVL1 PTK2 20224554 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SRPK1 PTK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CCR5 PTK2 25348397 N/A physical interaction ComPPI
MDM2 PTK2 25348397 N/A physical interaction ComPPI
BIN1 PTK2 25348397 N/A physical interaction ComPPI
RET PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
DAG1 PTK2 25348397 N/A physical interaction ComPPI
EGFR PTK2 15657067 24234451 24658140 25348397 association,physical association anti bait coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
IRS1 PTK2 25348397 N/A physical interaction ComPPI
ITGB4 PTK2 24234451 25348397 27178753 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
JAK2 PTK2 25348397 N/A physical interaction ComPPI
TGFB1I1 PTK2 21900206 24234451 25348397 9756887 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
BMX PTK2 25348397 N/A physical interaction ComPPI
CTTN PTK2 25348397 N/A physical interaction ComPPI
SH2D1A PTK2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
ASAP1 PTK2 25348397 N/A physical interaction ComPPI
STAP2 PTK2 25348397 N/A physical interaction ComPPI
DOK4 PTK2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
TSC1 PTK2 25348397 N/A physical interaction ComPPI
PTEN PTK2 23397142 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ITGA4 PTK2 25348397 N/A physical interaction ComPPI
LPXN PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AMPH PTK2 25348397 N/A physical interaction ComPPI
FYN PTK2 25348397 N/A physical interaction ComPPI
GNG2 PTK2 25348397 N/A physical interaction ComPPI
PTRH2 PTK2 21383007 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
CXCR4 PTK2 25348397 N/A physical interaction ComPPI
TRIM25 PTK2 25348397 N/A physical interaction ComPPI
SH2D1B PTK2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELAVL1 PTK2 25348397 N/A physical interaction ComPPI
ARHGAP26 PTK2 25348397 N/A physical interaction ComPPI
RB1CC1 PTK2 25348397 N/A physical interaction ComPPI
PDCD6IP PTK2 25348397 N/A physical interaction ComPPI
UBE2H PTK2 25348397 N/A physical interaction ComPPI
DDX39A PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT1 PTK2 25348397 N/A physical interaction ComPPI
STUB1 PTK2 25348397 N/A physical interaction ComPPI
STAT3 PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
NASP PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VPS16 PTK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1G PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATG12 PTK2 25348397 N/A physical interaction ComPPI
EZR PTK2 25348397 N/A physical interaction ComPPI
HCK PTK2 25348397 N/A physical interaction ComPPI
IGF1R PTK2 25348397 N/A physical interaction ComPPI
EPS8L2 PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB1 PTK2 25348397 N/A physical interaction ComPPI
RHOU PTK2 18086875 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
GSN PTK2 25348397 N/A physical interaction ComPPI
HES1 PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DCC PTK2 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
F13A1 PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN23 PTK2 18835089 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,fluorescence technology,pull down,protein kinase assay ComPPI,IntAct
TRMT6 PTK2 25348397 N/A physical interaction ComPPI
APP PTK2 25348397 N/A physical interaction ComPPI
PLCG1 PTK2 23397142 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PTK2 BCAR1 21034468 24234451 25348397 9285683 physical association coimmunoprecipitation,filter binding,physical interaction ComPPI,IntAct
PTK2 FGR 25348397 N/A physical interaction ComPPI
PTK2 NEO1 25348397 N/A physical interaction ComPPI
PTK2 TP53 15855171 19857493 24234451 25241761 25348397 colocalization,physical association anti bait coimmunoprecipitation,pull down,physical interaction,confocal microscopy,proximity ligation assay ComPPI,IntAct
PTK2 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTK2 NACAD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTK2 ZNF331 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
PTK2 TRIM72 25348397 N/A physical interaction ComPPI
PTK2 OTUD6B 25348397 N/A physical interaction ComPPI
PTK2 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PTK2 TRIM15 25348397 N/A physical interaction ComPPI
PTK2 TEK 25348397 N/A physical interaction ComPPI
PTK2 TNS3 19732724 24234451 25348397 colocalization,physical association far western blotting,pull down,fluorescence microscopy ComPPI,IntAct
PTK2 DVL1P1 20224554 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PTK2 MAL 22366891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANGPTL4 PTK2 21397862 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PTK2 PTK2 24234451 24480479 N/A x-ray crystallography IntAct
ANXA2 PTK2 24234451 30021884 physical association cross-linking study IntAct
CDK5 PTK2 11160818 12941275 17096371 20519501 21876001 25525271 27898060 stimulant N/A OmniPath
SRC PTK2 10085298 10931187 11027591 11313859 11331870 11438458 11468295 11696015 11839772 11857088 11891289 11927607 11980671 12023386 12084011 12087088 12110680 12387730 12408869 12531888 12558988 12615911 12659633 12753909 12871985 12927054 12960434 14603053 14610060 14670178 14712221 14978737 15077193 15123632 15126359 15247219 15316068 15371459 15389641 15561106 15598735 15611085 15611137 15735019 15951569 16126008 16291744 16415178 16510472 16540596 16760434 16920701 16966330 17016520 17088251 17117420 17192257 17234784 17289681 17389395 17449913 17525734 17653080 17828307 18083107 18437915 18664639 18676832 19339212 19369195 19525980 19534553 19664994 19962670 20068231 20160475 20180147 20501847 20802513 21034468 21454698 21855630 22366891 22761432 22940691 23065768 23264741 23454549 23637231 24608426 24609268 24655477 24858039 25241761 25275301 25617365 25814554 26068982 27898060 7529876 7997267 8051157 8054685 8816475 8824286 8941336 9507031 9822703 stimulant N/A OmniPath
PTK2 SRC 10085298 10931187 11927607 11980671 12387730 12558988 12615911 16291744 16966330 17525734 21034468 21855630 23065768 25241761 25814554 27898060 7505391 7529876 7997267 8054685 8816475 8941336 9507031 9822703 stimulant N/A OmniPath
YES1 PTK2 10821872 11035755 11839732 12482769 12558988 12639965 12754219 14572662 14656986 15800067 15817476 15958584 16491114 16818654 17234774 18032789 21276823 21289086 21852560 23397142 23466867 25416956 25817040 25868388 27898060 7597091 stimulant N/A OmniPath
LYN PTK2 11389892 25814554 27898060 9169439 stimulant N/A OmniPath
PKD1 PTK2 11113628 27898060 N/A N/A OmniPath
PTPN1 PTK2 16291744 27898060 9418872 inhibition N/A OmniPath
PTK2 CDH1 10671552 27898060 N/A N/A OmniPath
PTK2 FYN 10085136 11278857 12558988 27898060 7505391 stimulant N/A OmniPath
EGFR PTK2 10806474 20802513 24658140 25402006 27898060 stimulant N/A OmniPath
PTK2 ACTN1 11369769 20940419 23454549 27898060 inhibition N/A OmniPath
PTEN PTK2 10400703 10427092 11857088 15717329 23397142 27898060 9616126 inhibition N/A OmniPath
RET PTK2 12387730 15561106 15951569 16153436 17016520 17192257 17389395 18083107 19339212 19369195 19534553 19664994 20068231 21454698 25241761 27898060 7529876 9507031 stimulant N/A OmniPath
PTK2 RET 16153436 21454698 25241761 27898060 stimulant N/A OmniPath
PTK2 ITGB1 19889638 27898060 8649427 stimulant N/A OmniPath
PDGFRB PTK2 10806474 20802513 27898060 stimulant N/A OmniPath
ROCK1 PTK2 15247219 16760434 27898060 stimulant N/A OmniPath
CASP3 PTK2 10224094 27898060 9463408 inhibition N/A OmniPath
PTK2 ACTN3 11369769 15070900 27898060 inhibition N/A OmniPath
PTK2 WASL 16257963 17389395 18083107 19534553 27898060 N/A N/A OmniPath
PTK2 GRB2 10085298 10749687 10806474 12005431 12558988 16713569 21900206 27898060 7597091 7997267 8649427 9148935 stimulant N/A OmniPath
TP53 PTK2 15855171 18206965 18431400 19857493 25241761 27898060 inhibition N/A OmniPath
SHC1 PTK2 10749687 11980671 27898060 stimulant N/A OmniPath
PTK2 SHC1 10725339 10749687 11980671 27898060 stimulant N/A OmniPath
PTK2 PXN 10330411 10455189 10545505 10753828 10764815 10980697 11113628 11134073 11304546 11337490 11514617 11919182 12408869 14527389 17389395 18669648 18707149 20068231 20489202 21034468 21741599 22270917 27898060 7537852 7561682 7615549 8922390 9054445 9230116 9422762 9442086 9658172 9756887 stimulant N/A OmniPath
PTK2 PIK3R1 10806474 27898060 7537275 8649427 9416004 stimulant N/A OmniPath
PPP1CB PTK2 11513739 15975092 17274640 27898060 N/A N/A OmniPath
CRK PTK2 10085298 11314030 12370821 12615911 17016520 20068231 25814554 27898060 7509446 7529876 7561682 stimulant N/A OmniPath
PTK2 BCAR1 10753828 11514617 11577104 11839772 12119061 12135674 12615911 15673687 21034468 21855630 27898060 7479864 8649427 8662921 8810278 9038154 9285683 9360968 9360983 stimulant N/A OmniPath
RB1CC1 PTK2 10769033 12221124 27898060 N/A N/A OmniPath
PPP1CA PTK2 11513739 15975092 27898060 N/A N/A OmniPath
PTK2 GRB7 10446223 19473962 25814554 27898060 N/A N/A OmniPath
PTK2 PAK1 11278553 27898060 stimulant N/A OmniPath
PTPN11 PTK2 10082579 10655584 16920701 21726809 27898060 7589239 8986614 inhibition N/A OmniPath
MET PTK2 11909938 14739293 15026417 15561106 15707572 16782899 17317726 19815712 20658524 20802513 20802517 27898060 stimulant N/A OmniPath
INSR PTK2 17016520 17389395 19664994 20068231 27898060 7529876 9507031 stimulant N/A OmniPath
CAMK2A PTK2 15845548 27898060 stimulant N/A OmniPath
SELE PTK2 27898060 8609175 N/A N/A OmniPath
CD36 PTK2 20037584 27898060 N/A N/A OmniPath
CSK PTK2 27898060 7529872 9890993 stimulant N/A OmniPath
NCK2 PTK2 11950595 27898060 stimulant N/A OmniPath
FGR PTK2 12387730 27898060 stimulant N/A OmniPath
PPP1CC PTK2 11513739 15975092 27898060 N/A N/A OmniPath
PTK2 TRIO 12551902 27898060 N/A N/A OmniPath
PTK2B PTK2 16760434 27898060 stimulant N/A OmniPath
PTK2 ACTN4 23454549 27898060 inhibition,stimulant N/A OmniPath
PTK2 ATP2B4 12540962 25847233 27898060 N/A N/A OmniPath
BMX PTK2 11331870 23716717 27898060 stimulant N/A OmniPath
PTK2 SH3GL1 16054026 27898060 N/A N/A OmniPath
PTPN12 PTK2 10400703 11314030 11432829 19595712 27898060 9497381 inhibition N/A OmniPath
ACP1 PTK2 12055185 27898060 N/A N/A OmniPath
PTK2 NANOG 22493428 27898060 N/A N/A OmniPath
PTPN23 PTK2 17959146 18835089 27898060 N/A N/A OmniPath

Visualization










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