Gene Information gene info

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GENE：SIK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIK1
FullNmae salt inducible kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11142
EnsembleID ENSG00000142178
Uniprot P57059

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIK1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIK1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIK1 anoikis 19724060 These findings suggest that SIK1 is a key upstream regulator of p53-dependent anoikis that may be targeted in tumorigenesis. retulator signature

Go Annotation:

GeneSymbol Go id
SIK1 GO:0000287,GO:0000287,GO:0002028,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0006468,GO:0006468,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0035556,GO:0035556,GO:0035556,GO:0042826,GO:0043153,GO:0043276,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:0106310,GO:2000210

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIK1 hsa:150094 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIK1 SMAD7 19030025 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR SIK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SIK1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SIK1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SIK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002FC5B0 SIK1 20371350 22473208 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00001799A3 SIK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BBF48 SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SIK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000419B5A SIK1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 SIK1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 SIK1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 SIK1 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A SIK1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C SIK1 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 SIK1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D SIK1 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A SIK1 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 SIK1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 SIK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000759FD9 SIK1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 SIK1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004F24A9 SIK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 SIK1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK11 SIK1 22135298 phosphorylation N/A PhosphoSite
SIK1 NCOR2 22135298 phosphorylation N/A PhosphoSite
YWHAE SIK1 25361965 interaction type N/A PTMCode2
SIK1 YWHAE 25361965 interaction type N/A PTMCode2
SIK1 CRTC2 25361965 interaction type N/A PTMCode2
CRTC2 SIK1 25361965 interaction type N/A PTMCode2
SIK1 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB SIK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PITX1 SIK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIK2 SIK1 25348397 N/A physical interaction ComPPI
NMNAT1 SIK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKACA SIK1 25348397 N/A physical interaction ComPPI
VAPA SIK1 14525934 25348397 9920726 N/A experimental interaction detection,in vitro ComPPI,HPRD
YWHAZ SIK1 14525934 16306228 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PRKAA1 SIK1 25348397 N/A physical interaction ComPPI
CD247 SIK1 24234451 24502978 25348397 association pull down ComPPI,IntAct
XPO1 SIK1 25348397 N/A physical interaction ComPPI
YWHAE SIK1 16306228 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RNF2 SIK1 25348397 N/A physical interaction ComPPI
STK11 SIK1 25348397 N/A physical interaction ComPPI
MAP3K7 SIK1 25348397 N/A physical interaction ComPPI
TAB2 SIK1 25348397 N/A physical interaction ComPPI
HDAC5 SIK1 25348397 N/A physical interaction ComPPI
SUPT5H SIK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELAVL1 SIK1 25348397 N/A physical interaction ComPPI
UBE2E1 SIK1 25348397 N/A physical interaction ComPPI
MESD SIK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CRTC2 SIK1 14525934 16306228 24234451 25348397 phosphorylation reaction experimental interaction detection,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
SIK1 RPL3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SIK1 GINS4 25348397 N/A physical interaction ComPPI
SIK1 TIMM10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIK1 LHX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIK1 PRTFDC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GINS2 SIK1 25348397 N/A physical interaction ComPPI
SIK3 SIK1 25348397 N/A physical interaction ComPPI
SIK1 CRTC2 15454081 16306228 16817901 18669648 27898060 inhibition N/A OmniPath
STK11 SIK1 14976552 18348280 27898060 stimulant N/A OmniPath
SIK1 IRS1 12351658 12624099 15199052 16099428 16129690 27898060 N/A N/A OmniPath
SIK1 HDAC4 10958686 27898060 N/A N/A OmniPath
SIK1 CRTC3 16817901 27898060 inhibition N/A OmniPath
SIK1 CRTC1 16817901 17525332 18669648 27898060 inhibition,stimulant N/A OmniPath

Visualization










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