GENE:CA9
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CA9 |
| FullNmae | carbonic anhydrase 9 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1383 |
| EnsembleID | ENSG00000107159 |
| Uniprot | Q16790 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CA9 | alkaliptosis | 39937414 | In the alkaliptosis gene set (IKBKB, NFKB1, CA9, CHUK, IKBKG, and RELA), NFKB1, CHUK, and IKBKG exhibited differential expression in TCGA-KIRC. | retulator signature |
| CA9 | alkaliptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CA9 | GO:0001666,GO:0002009,GO:0004089,GO:0004089,GO:0004089,GO:0005515,GO:0005730,GO:0005886,GO:0005886,GO:0005886,GO:0006730,GO:0008270,GO:0009410,GO:0016020,GO:0016323,GO:0031528,GO:0033574,GO:0046903,GO:0140677 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CA9 | hsa:768 | path:hsa00910 | Nitrogen metabolism - Homo sapiens (human) |
| CA9 | hsa:768 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CA9 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOS | CA9 | 11672442 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| HIF1A | CA9 | 12171890 17486380 18971253 19154183 19238077 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| YBX1 | CA9 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | CA9 | 11672442 12615703 16270297 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SP3 | CA9 | 11672442 12615703 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| EGR1 | CA9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CA9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AHR | CA9 | 19154183 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNT | CA9 | 22387692 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF4 | CA9 | 19564335 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | CA9 | 16270297 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EPAS1 | CA9 | 12171890 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | CA9 | 18381358 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC4 | CA9 | 20110259 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | CA9 | 12615703 16270297 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VHL | CA9 | 15754010 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELK1 | CA9 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | CA9 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KPNA2 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| GLRX3 | CA9 | 24234451 25348397 26871637 | physical association | two hybrid,two hybrid array,bimolecular fluorescence complementation,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ATP5F1B | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| CA2 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | CA9 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| XPO5 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| TNPO1 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| IPO7 | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| CTNNB1 | CA9 | 14525934 14567991 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CSE1L | CA9 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | CTNNA1 | 14525934 14567991 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CA9 | FLOT1 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | CAND1 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | G3BP2 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | ATP5F1A | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | RTCB | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | RPS5 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | CAND2 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | ACACA | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | IPO9 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | IPO4 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | IPO5 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | XPOT | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | TNPO3 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | ATXN10 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | HEATR3 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | SAAL1 | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | SRPRB | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | HADHA | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | ATP4A | 25348397 | N/A | physical interaction | ComPPI |
| CA9 | CSRP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CA9 | CA9 | 19805286 24234451 | N/A | x-ray crystallography | IntAct |
| PRKACA | CA9 | 22037869 27898060 | stimulant | N/A | OmniPath |
