GENE:AASDHPPT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AASDHPPT |
| FullNmae | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14235 |
| EnsembleID | ENSG00000149313 |
| Uniprot | Q9NRN7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AASDHPPT | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AASDHPPT | GO:0000287,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0008897,GO:0008897,GO:0008897,GO:0009258,GO:0015939,GO:0019878,GO:0051604,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AASDHPPT | hsa:60496 | path:hsa00770 | Pantothenate and CoA biosynthesis - Homo sapiens (human) |
| AASDHPPT | hsa:60496 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | AASDHPPT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | AASDHPPT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000028BB8 | AASDHPPT | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000F31F4 | AASDHPPT | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | AASDHPPT | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000122ED0 | AASDHPPT | 19088304 21572407 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS0000008A99 | AASDHPPT | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | AASDHPPT | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | AASDHPPT | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | AASDHPPT | 20371350 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | AASDHPPT | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000081E1F | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EBD4B | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C28B2 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016E46F | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C04A2 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F8148 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BD367 | AASDHPPT | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E1E9E | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000202460 | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BBF48 | AASDHPPT | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000321A1A | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000100748 | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003758F0 | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F5B39 | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C7B2B | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | AASDHPPT | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EIF1B | AASDHPPT | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CRX | AASDHPPT | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SGTA | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| MDFI | AASDHPPT | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| PPP1R3C | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| JUN | AASDHPPT | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| UBE2D2 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| PAXIP1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| SIAH1 | AASDHPPT | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| DLD | AASDHPPT | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| NTRK1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| TRAF2 | AASDHPPT | 14525934 16189514 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| HNRNPH1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| NOL3 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| RAE1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| SOD1 | AASDHPPT | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| TRIP13 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| DAZAP1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| EHD1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| ULK2 | AASDHPPT | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ADSS2 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA1 | AASDHPPT | 25348397 | N/A | physical interaction | ComPPI |
| STIL | AASDHPPT | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| AASDHPPT | USP22 | 19615732 24234451 25348397 25416956 | physical association | anti tag coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| AASDHPPT | BABAM1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| AASDHPPT | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | CAPZA2 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | PLCG1 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | ZC3HC1 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | ANGPTL4 | 25348397 | N/A | physical interaction | ComPPI |
| AASDHPPT | HLA-B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| AASDHPPT | SLX4 | 19596235 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| AASDHPPT | PLEKHA7 | 24234451 25348397 28877994 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
