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GENE：ABCB11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ABCB11
FullNmae ATP binding cassette subfamily B member 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:42
EnsembleID ENSG00000073734
Uniprot O95342

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ABCB11 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ABCB11 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Copper metabolism disease related genes

Go Annotation:

GeneSymbol Go id
ABCB11 GO:0000139,GO:0005515,GO:0005524,GO:0005768,GO:0005886,GO:0005886,GO:0005886,GO:0006631,GO:0006699,GO:0006805,GO:0006805,GO:0006855,GO:0006855,GO:0006979,GO:0008206,GO:0008206,GO:0008206,GO:0008559,GO:0008559,GO:0009986,GO:0014070,GO:0015125,GO:0015125,GO:0015126,GO:0015126,GO:0015126,GO:0015126,GO:0015144,GO:0015432,GO:0015432,GO:0015432,GO:0015432,GO:0015432,GO:0015721,GO:0015721,GO:0015721,GO:0015721,GO:0015722,GO:0015722,GO:0015722,GO:0015722,GO:0016324,GO:0016324,GO:0016567,GO:0016567,GO:0016887,GO:0031998,GO:0034219,GO:0038183,GO:0042632,GO:0043627,GO:0045471,GO:0046581,GO:0046618,GO:0046618,GO:0046691,GO:0055037,GO:0055038,GO:0055085,GO:0055088,GO:0055091,GO:0070062,GO:0120189,GO:1904251

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ABCB11 hsa:8647 path:hsa01522 Endocrine resistance - Homo sapiens (human)
ABCB11 hsa:8647 path:hsa02010 ABC transporters - Homo sapiens (human)
ABCB11 hsa:8647 path:hsa04976 Bile secretion - Homo sapiens (human)
ABCB11 hsa:8647 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPARGC1A ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NCOA1 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
CYTH3 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
CARM1 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NCOR1 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NCOR2 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NR0B2 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NR1H4 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ABCB11 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 ABCB11 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ABCB11 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
RXRA ABCB11 11387316 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
NR1H4 ABCB11 11387316 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ABCB11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR5A2 ABCB11 18270374 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000CBE63 ABCB11 22767443 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000CBE63 ABCB11 22767443 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005485E8 ABCB11 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 ABCB11 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 ABCB11 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 ABCB11 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 ABCB11 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F ABCB11 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 ABCB11 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DDIT4L ABCB11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HAX1 ABCB11 14525934 15159385 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
AP2A1 ABCB11 25348397 N/A physical interaction ComPPI
NR4A1 ABCB11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ABCB11 LY6D 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
H3C15 ABCB11 24234451 30021884 physical association cross-linking study IntAct

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