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GENE：MAP2K2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K2
FullNmae mitogen-activated protein kinase kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6842
EnsembleID ENSG00000126934
Uniprot P36507

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K2 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
MAP2K2 cuproptosis 38348451 Components of the MAPK signaling pathway. MAPK pathways can be activated in response to stress and may contribute to cell death mechanisms. CRGs in the cuproptosis pathway
MAP2K2 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
MAP2K2 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MAP2K2 GO:0000165,GO:0004674,GO:0004708,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005778,GO:0005783,GO:0005794,GO:0005794,GO:0005829,GO:0005874,GO:0005911,GO:0005925,GO:0007507,GO:0009898,GO:0010628,GO:0030165,GO:0030878,GO:0032872,GO:0036289,GO:0043410,GO:0043539,GO:0045893,GO:0046872,GO:0048009,GO:0048471,GO:0048538,GO:0048679,GO:0050772,GO:0060324,GO:0060440,GO:0060502,GO:0070371,GO:0070371,GO:0071902,GO:0090170,GO:0097110,GO:0106310,GO:2000147,GO:2000641

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K2 hsa:5605 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa01522 Endocrine resistance - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04140 Autophagy - animal - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04148 Efferocytosis - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04210 Apoptosis - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04218 Cellular senescence - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04540 Gap junction - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04720 Long-term potentiation - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04730 Long-term depression - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04916 Melanogenesis - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04929 GnRH secretion - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04934 Cushing syndrome - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05010 Alzheimer disease - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05132 Salmonella infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05135 Yersinia infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05160 Hepatitis C - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05164 Influenza A - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05200 Pathways in cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05210 Colorectal cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05213 Endometrial cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05214 Glioma - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05215 Prostate cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05216 Thyroid cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05218 Melanoma - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05219 Bladder cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05224 Breast cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05226 Gastric cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
MAP2K2 hsa:5605 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP2K2 MAPK3 11134045 11242034 18988627 21071413 23180781 23331499 7687743 8226933 8626767 stimulation,physical association pull down InnateDB,SignaLink,SignaLink
MAP2K2 EGR1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K2 MAPK1 11134045 11823456 16293107 18988627 23331499 stimulation N/A SignaLink,SignaLink
MAPK1 MAP2K2 11823456 21071413 23331499 9922370 interaction type N/A SignaLink,SignaLink
BRAF MAP2K2 23331499 8668348 stimulation N/A SignaLink,SignaLink
RAF1 MAP2K2 16293107 18988627 23331499 8157000 8393135 9671314 9808624 stimulation N/A SignaLink,SignaLink
MAP3K7 MAP2K2 13130464 23109003 8177321 9851932 chemical activation reaction N/A SignaLink
MAP2K7 MAP2K2 23109003 7997270 chemical activation reaction N/A SignaLink
MAP3K1 MAP2K2 15032589 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP2K2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAP2K2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP2K2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP2K2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP2K2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP2K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 MAP2K2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000042935A MAP2K2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 MAP2K2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 MAP2K2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 MAP2K2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 MAP2K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 MAP2K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 MAP2K2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001A122A MAP2K2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 MAP2K2 22135298 phosphorylation N/A PhosphoSite
PDPK1 MAP2K2 22135298 phosphorylation N/A PhosphoSite
PLK1 MAP2K2 22135298 phosphorylation N/A PhosphoSite
MAP2K2 MAPK3 22135298 phosphorylation N/A PhosphoSite
MAP2K2 KRT8 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K2 22135298 phosphorylation N/A PhosphoSite
BRAF MAP2K2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HNRNPK MAP2K2 25348397 N/A two hybrid ComPPI
MOS MAP2K2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNW1 MAP2K2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 MAP2K2 25348397 N/A physical interaction ComPPI
MAP2K2 MAPK1 11134045 11823456 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP2K2 ARAF 11909642 14525934 21988832 24234451 24746704 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
MAP2K2 DUSP3 10224087 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K2 MAPK3 14525934 25348397 7687743 8226933 8626767 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K2 CASP9 12792650 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K2 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2K2 LAMTOR3 14525934 25348397 9733512 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K2 GRIN1 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2K2 RAF1 11909642 14525934 21988832 24234451 24746704 25348397 8157000 8393135 9671314 9808624 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MAP2K2 RGS12 14525934 17380122 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
MAP2K2 BRAF 14525934 17979178 24234451 24746704 25348397 25600339 8668348 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
MAP2K2 MEPCE 25348397 N/A physical interaction ComPPI
MAP2K2 COPS5 18624398 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach ComPPI,IntAct
MAP2K2 YWHAB 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K2 MAP2K1 25348397 N/A physical interaction ComPPI
MAP2K2 WDR83 25348397 N/A physical interaction ComPPI
MAP2K2 MAPK8 25348397 N/A physical interaction ComPPI
MAP2K2 LIG4 25348397 N/A physical interaction ComPPI
MAP2K2 PEX14 21525035 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MAP2K2 ZNF207 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K2 RIPOR2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K2 IQGAP1 25348397 N/A physical interaction ComPPI
MAP2K2 NFE2L2 25348397 N/A physical interaction ComPPI
MAP2K2 EGFR 25348397 N/A physical interaction ComPPI
MAP2K2 CCNDBP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAP2K2 ART3 25348397 N/A physical interaction ComPPI
MAP2K2 ACTL6A 25348397 N/A physical interaction ComPPI
MAP2K2 TNF 25348397 N/A physical interaction ComPPI
MAP2K2 PDLIM5 25348397 N/A physical interaction ComPPI
MAP2K2 RPE 25348397 N/A physical interaction ComPPI
MAP2K2 TXN 25348397 N/A physical interaction ComPPI
MAP2K2 XPO1 25348397 N/A physical interaction ComPPI
MAP2K2 SERPINB2 25348397 N/A physical interaction ComPPI
MAP2K2 TUBA4A 25348397 N/A physical interaction ComPPI
MAP2K2 CD70 25348397 N/A physical interaction ComPPI
MAP2K2 NOCT 25348397 N/A physical interaction ComPPI
MAP2K2 DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP2K2 TRIM25 25348397 N/A physical interaction ComPPI
MAP2K2 HNRNPL 25348397 N/A physical interaction ComPPI
MAP2K2 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAP2K2 KSR1 11909642 24234451 25348397 27086506 association,physical association anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct
MAP2K2 DLG1 21615688 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,fluorescence microscopy ComPPI,IntAct,OmniPath
MAP2K2 PKM 25348397 N/A protein kinase assay ComPPI
MAP2K2 HSCB 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MAP2K2 KSR2 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP2K2 MAP2K2 11909642 14525934 17192257 24234451 8226933 physical association two hybrid,experimental interaction detection HPRD,IntAct
MAP3K8 MAP2K2 12506122 12609978 15466476 17101779 17906627 18187448 27898060 stimulant N/A OmniPath
MAP2K2 KRT8 10623656 11781324 11788583 15368451 15707998 15763073 15972820 16343483 16554440 17535969 18617517 19115206 19246484 19796649 20663917 20724476 22114688 23358244 25963979 27898060 9211903 N/A N/A OmniPath
MAP2K2 CASP9 12792650 18669648 27898060 N/A N/A OmniPath
BRAF MAP2K2 18039929 25600339 27898060 8668348 stimulant N/A OmniPath
PDPK1 MAP2K2 15175348 27898060 stimulant N/A OmniPath
MAP2K2 MAPK6 18039929 27898060 stimulant N/A OmniPath
MAP2K2 MAPK3 11134045 11242034 11251083 1411546 15580310 15951569 16497976 16887817 17081983 17192257 17389395 17906627 18083107 18669648 18691976 18707149 18983981 19369195 19494114 19534553 19651622 19690332 19901323 20068231 27898060 7687743 8226933 8626767 9006895 stimulant N/A OmniPath
RAF1 MAP2K2 11909642 16293107 16364241 17116858 18039929 18669648 19058874 19369195 21988832 27898060 8157000 8393135 9671314 9808624 stimulant N/A OmniPath
MAPK1 MAP2K2 11134045 11823456 12788955 16293107 21675959 27898060 9922370 stimulant N/A OmniPath
MAP2K2 MAPK1 11134045 11823456 11971971 12788955 15592455 15951569 16094384 16293107 17081983 17192257 17389395 17906627 18039929 18083107 18669648 18691976 19053285 19369195 19494114 19534553 19690332 21675959 27898060 9922370 stimulant N/A OmniPath
MAP2K2 PPARG 18596912 27898060 stimulant N/A OmniPath
PPP2CA MAP2K2 20626350 27898060 inhibition N/A OmniPath
ARAF MAP2K2 11909642 18039929 21779497 21988832 25852190 27898060 stimulant N/A OmniPath
DUSP3 MAP2K2 10224087 27898060 N/A N/A OmniPath

Visualization










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