Gene Information gene info

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GENE：ACLY

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACLY
FullNmae ATP citrate lyase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:115
EnsembleID ENSG00000131473
Uniprot P53396

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACLY cuproptosis 37243753 However, there are very few studies of cuproptosis in GC. In this paper, a prediction model related to cuproptosis was established and verified through data mining, and the six genes related to cuproptosis were ACLY, FGD6, SERPINE1, SPATA13, RANGAP1, and ADGRE5. genes related to cuproptosis

Go Annotation:

GeneSymbol Go id
ACLY GO:0003878,GO:0003878,GO:0003878,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005829,GO:0005829,GO:0006085,GO:0006085,GO:0006099,GO:0006101,GO:0006107,GO:0006633,GO:0006633,GO:0006695,GO:0008610,GO:0015936,GO:0016020,GO:0035578,GO:0046872,GO:0070062,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACLY hsa:47 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
ACLY hsa:47 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELANE ACLY 19506020 23180781 physical association two hybrid InnateDB
ISG15 ACLY 16009940 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ACLY 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ACLY 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACLY 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 ACLY 10777536 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000CF1D2 ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 ACLY 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000096022 ACLY 25416803 27317765 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
KPNA2 ACLY 25348397 N/A physical interaction ComPPI
HNRNPK ACLY 25348397 N/A physical interaction ComPPI
KPNA4 ACLY 25348397 N/A physical interaction ComPPI
HSPA8 ACLY 25348397 N/A physical interaction ComPPI
BAG3 ACLY 25348397 N/A physical interaction ComPPI
ISG15 ACLY 25348397 N/A physical interaction ComPPI
PPP2R1A ACLY 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
TUBB ACLY 25348397 N/A physical interaction ComPPI
KEAP1 ACLY 25348397 N/A physical interaction ComPPI
MCM6 ACLY 25348397 N/A physical interaction ComPPI
MCM2 ACLY 25348397 N/A physical interaction ComPPI
FBXW7 ACLY 25348397 N/A physical interaction ComPPI
SHC1 ACLY 25348397 N/A physical interaction ComPPI
JUN ACLY 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
KAT2B ACLY 25348397 N/A physical interaction ComPPI
PRKACA ACLY 10653665 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GSK3B ACLY 10653665 14525934 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CUL3 ACLY 25348397 N/A physical interaction ComPPI
CDKN2A ACLY 17955473 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
HGS ACLY 25348397 N/A physical interaction ComPPI
UBC ACLY 25348397 N/A physical interaction ComPPI
NTRK1 ACLY 25348397 N/A physical interaction ComPPI
PRMT1 ACLY 25348397 N/A physical interaction ComPPI
STIP1 ACLY 25348397 N/A physical interaction ComPPI
CFTR ACLY 25348397 N/A physical interaction ComPPI
CCNA1 ACLY 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HUWE1 ACLY 25348397 N/A physical interaction ComPPI
USP13 ACLY 25348397 N/A physical interaction ComPPI
ARF6 ACLY 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPE ACLY 25348397 N/A physical interaction ComPPI
CUL2 ACLY 25348397 N/A physical interaction ComPPI
VHL ACLY 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PPP2R2A ACLY 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 ACLY 25348397 N/A physical interaction ComPPI
WWOX ACLY 25348397 N/A physical interaction ComPPI
DNM1L ACLY 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATXN3 ACLY 25348397 N/A physical interaction ComPPI
PYGB ACLY 25348397 N/A physical interaction ComPPI
EEF1D ACLY 25348397 N/A physical interaction ComPPI
ACLY TFE3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACLY IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACLY PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACLY NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACLY TERF1 25348397 N/A physical interaction ComPPI
ACLY TERF2 25348397 N/A physical interaction ComPPI
ACLY HDAC5 25348397 N/A physical interaction ComPPI
ACLY SIRT7 25348397 N/A physical interaction ComPPI
ACLY CAND1 25348397 N/A physical interaction ComPPI
ACLY APP 25348397 N/A physical interaction ComPPI
ACLY FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ACLY CDKN2A 25348397 N/A physical interaction ComPPI
ACLY PPP6C 25348397 N/A physical interaction ComPPI
ACLY SRRT 25348397 N/A physical interaction ComPPI
ACLY MAGED2 25348397 N/A physical interaction ComPPI
ACLY NCL 25348397 N/A physical interaction ComPPI
ACLY ASB15 25348397 N/A physical interaction ComPPI
ACLY TRIM25 25348397 N/A physical interaction ComPPI
ACLY STAU1 25348397 N/A physical interaction ComPPI
ACLY UBR4 25348397 N/A physical interaction ComPPI
ACLY CUL7 25348397 N/A physical interaction ComPPI
ACLY OBSL1 25348397 N/A physical interaction ComPPI
ACLY CCDC8 25348397 N/A physical interaction ComPPI
ACLY SIRT6 25348397 N/A physical interaction ComPPI
ACLY CTH 25348397 N/A physical interaction ComPPI
ACLY CS 25348397 N/A physical interaction ComPPI
ACLY NAPRT 25348397 N/A physical interaction ComPPI
ACLY SDHA 25348397 N/A physical interaction ComPPI
ACLY SDHB 25348397 N/A physical interaction ComPPI
ACLY AHSA1 25348397 N/A physical interaction ComPPI
ACLY NUP107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACLY ATF6 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACLY CRY1 25348397 N/A physical interaction ComPPI
ACLY CRY2 25348397 N/A physical interaction ComPPI
ACLY DERL1 25348397 N/A physical interaction ComPPI
ACLY ZNF746 25348397 N/A physical interaction ComPPI
ACLY DUSP13 25348397 N/A physical interaction ComPPI
ACLY DUSP13 25348397 N/A physical interaction ComPPI
ACLY BRCA1 25348397 N/A physical interaction ComPPI
ACLY EIF4A1 25348397 N/A physical interaction ComPPI
ACLY SEC16A 25348397 N/A physical interaction ComPPI
ACLY KLHL25 25348397 N/A physical interaction ComPPI
ACLY HNRNPH1 25348397 N/A physical interaction ComPPI
ACLY RPS3 25348397 N/A physical interaction ComPPI
ACLY MC1R 25348397 N/A physical interaction ComPPI
ACLY TUBB3 25348397 N/A physical interaction ComPPI
ACLY MCM7 25348397 N/A physical interaction ComPPI
ACLY TNFRSF10D 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ACLY BCAR3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ACLY LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ACLY RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ACLY TFAP2C 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
ACLY OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
ACLY PPP2R2D 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
ACLY ACLY 10653665 14525934 9116495 N/A experimental interaction detection HPRD
PRKACA ACLY 10653665 17924679 18088087 18452278 18669648 18767875 19415658 27898060 N/A N/A OmniPath
AKT1 ACLY 15302935 17081983 17924679 18088087 18669648 18691976 19369195 27898060 N/A N/A OmniPath
ISG15 ACLY 16009940 16139798 27898060 N/A N/A OmniPath
DAPK1 ACLY 10653665 16464493 2176822 27898060 N/A N/A OmniPath
GSK3B ACLY 10653665 17353931 20058876 27898060 N/A N/A OmniPath
PHPT1 ACLY 12788074 27898060 N/A N/A OmniPath

Visualization










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