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GENE：ACO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACO1
FullNmae aconitase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:117
EnsembleID ENSG00000122729
Uniprot P21399

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACO1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACO1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACO1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ACO1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration

Go Annotation:

GeneSymbol Go id
ACO1 GO:0003723,GO:0003723,GO:0003994,GO:0003994,GO:0003994,GO:0005515,GO:0005737,GO:0005737,GO:0005739,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0006099,GO:0006101,GO:0006101,GO:0006101,GO:0006417,GO:0006879,GO:0009791,GO:0010040,GO:0030350,GO:0030350,GO:0030350,GO:0046872,GO:0047780,GO:0050892,GO:0051538,GO:0051538,GO:0051539,GO:0051539,GO:0051539,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACO1 hsa:48 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
ACO1 hsa:48 path:hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
ACO1 hsa:48 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACO1 hsa:48 path:hsa01200 Carbon metabolism - Homo sapiens (human)
ACO1 hsa:48 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
ACO1 hsa:48 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACO1 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ACO1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ACO1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ACO1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYT1 ACO1 16886906 trascriptional regulation,stimulation inferred by curator TFlink
MTF1 ACO1 16886906 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ACO1 16886906 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ACO1 16886906 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000034979B ACO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF ACO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA ACO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001D6605 ACO1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA ACO1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TXNDC17 ACO1 25348397 N/A physical interaction ComPPI
NTRK1 ACO1 25348397 N/A physical interaction ComPPI
ENO1 ACO1 25348397 N/A physical interaction ComPPI
YBX1 ACO1 24234451 25348397 25497084 association anti bait coimmunoprecipitation ComPPI,IntAct
PXN ACO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SGCG ACO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
CLTC ACO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
FUBP1 ACO1 25348397 N/A physical interaction ComPPI
STRAP ACO1 25348397 N/A physical interaction ComPPI
FBXL5 ACO1 25348397 N/A physical interaction ComPPI
H2AC4 ACO1 25348397 N/A physical interaction ComPPI
SHMT2 ACO1 25348397 N/A physical interaction ComPPI
MYBPC1 ACO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LGALS1 ACO1 25348397 N/A physical interaction ComPPI
CYLD ACO1 25348397 N/A physical interaction ComPPI
CTPS1 ACO1 25348397 N/A physical interaction ComPPI
NEB ACO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
GBE1 ACO1 25348397 N/A physical interaction ComPPI
APP ACO1 25348397 N/A physical interaction ComPPI
NXF1 ACO1 25348397 N/A physical interaction ComPPI
MOV10 ACO1 25348397 N/A physical interaction ComPPI
ACO1 C12ORF57 25348397 N/A physical interaction ComPPI
ACO1 PSMG1 25348397 N/A physical interaction ComPPI
ACO1 CCDC69 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DCPS ACO1 25348397 N/A physical interaction ComPPI
ACO1 SLC7A9 26659116 27898060 N/A N/A OmniPath
PRKCA ACO1 15263083 15636585 16424901 27898060 8262977 inhibition N/A OmniPath

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