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GENE：ACO2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACO2
FullNmae aconitase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:118
EnsembleID ENSG00000100412
Uniprot Q99798

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACO2 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
ACO2 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
ACO2 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ACO2 GO:0001889,GO:0003994,GO:0003994,GO:0005506,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006099,GO:0006099,GO:0006099,GO:0006101,GO:0006102,GO:0035900,GO:0047780,GO:0051538,GO:0051539

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACO2 hsa:50 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
ACO2 hsa:50 path:hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
ACO2 hsa:50 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACO2 hsa:50 path:hsa01200 Carbon metabolism - Homo sapiens (human)
ACO2 hsa:50 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
ACO2 hsa:50 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK2 ACO2 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP ACO2 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ACO2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ACO2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC ACO2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ACO2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ACO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ACO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
VAPA ACO2 25348397 N/A physical interaction ComPPI
NTRK1 ACO2 25348397 N/A physical interaction ComPPI
SIN3A ACO2 25348397 N/A physical interaction ComPPI
ATP1B1 ACO2 25348397 N/A physical interaction ComPPI
ACAA2 ACO2 25348397 N/A physical interaction ComPPI
VCAM1 ACO2 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 ACO2 25348397 N/A physical interaction ComPPI
IDH3A ACO2 25348397 N/A physical interaction ComPPI
IDH3G ACO2 25348397 N/A physical interaction ComPPI
PSMD4 ACO2 25348397 N/A physical interaction ComPPI
ALDOC ACO2 25348397 N/A physical interaction ComPPI
PDK1 ACO2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRIM25 ACO2 25348397 N/A physical interaction ComPPI
CLPP ACO2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
MLH1 ACO2 20706999 24234451 25348397 physical association two hybrid ComPPI,IntAct
SOD1 ACO2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SRRM2 ACO2 25348397 N/A physical interaction ComPPI
CKB ACO2 25348397 N/A physical interaction ComPPI
ASB9 ACO2 25348397 N/A physical interaction ComPPI
GPD1 ACO2 25348397 N/A physical interaction ComPPI
ALDOA ACO2 25348397 N/A physical interaction ComPPI
SUMO4 ACO2 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACO2 ATXN1L 25348397 N/A physical interaction ComPPI
ACO2 APP 25348397 N/A physical interaction ComPPI
ACO2 AK3 25348397 N/A physical interaction ComPPI
ACO2 ACAT1 25348397 N/A physical interaction ComPPI
ACO2 MYH7B 25348397 N/A physical interaction ComPPI
ACO2 ALDH5A1 25348397 N/A physical interaction ComPPI
ACO2 ATP5PB 25348397 N/A physical interaction ComPPI
ACO2 ATP5PF 25348397 N/A physical interaction ComPPI
ACO2 GPD1L 25348397 N/A physical interaction ComPPI
ACO2 GPD2 25348397 N/A physical interaction ComPPI
ACO2 PITPNB 25348397 N/A physical interaction ComPPI
SOD2 ACO2 25348397 N/A physical interaction ComPPI
ESD ACO2 25348397 N/A physical interaction ComPPI
HSCB ACO2 24234451 25348397 28380382 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
C5AR2 ACO2 24234451 28298427 physical association ubiquitin reconstruction IntAct
ACO2 TCIM 24234451 30021884 physical association cross-linking study IntAct

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