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GENE：ACP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACP1
FullNmae acid phosphatase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:122
EnsembleID ENSG00000143727
Uniprot P24666

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACP1 cuproptosis 36313717 Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) Proteins carrying iron-sulfur cluster
ACP1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins

Go Annotation:

GeneSymbol Go id
ACP1 GO:0003993,GO:0004725,GO:0004725,GO:0004726,GO:0005515,GO:0005737,GO:0005829,GO:0009898,GO:0042383,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACP1 hsa:52 path:hsa00730 Thiamine metabolism - Homo sapiens (human)
ACP1 hsa:52 path:hsa00740 Riboflavin metabolism - Homo sapiens (human)
ACP1 hsa:52 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACP1 hsa:52 path:hsa04520 Adherens junction - Homo sapiens (human)
ACP1 hsa:52 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACP1 EPHA2 12167657 23331499 stimulation N/A SignaLink
EPHB1 ACP1 23331499 9499402 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ACP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ACP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000016C318 ACP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 ACP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BB229 ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 ACP1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C ACP1 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LCK ACP1 22135298 phosphorylation N/A PhosphoSite
FABP4 ACP1 25361965 interaction type N/A PTMCode2
ACP1 FABP4 25361965 interaction type N/A PTMCode2
ACP1 INSR 25361965 interaction type N/A PTMCode2
INSR ACP1 25361965 interaction type N/A PTMCode2
ACP1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 ACP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF1B ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ZBTB43 ACP1 25348397 N/A physical interaction ComPPI
PAK2 ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PCBP1 ACP1 25348397 N/A physical interaction ComPPI
ACTB ACP1 25348397 N/A physical interaction ComPPI
KEAP1 ACP1 25348397 N/A physical interaction ComPPI
MCM2 ACP1 25348397 N/A physical interaction ComPPI
DUSP12 ACP1 25348397 N/A physical interaction ComPPI
KDR ACP1 10608891 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EPHB2 ACP1 14525934 25348397 9499402 N/A experimental interaction detection,physical interaction ComPPI,HPRD
COPS5 ACP1 25348397 N/A physical interaction ComPPI
ZAP70 ACP1 11976341 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DLD ACP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PITPNA ACP1 25348397 N/A physical interaction ComPPI
EPHA2 ACP1 12167657 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DUSP1 ACP1 25348397 N/A physical interaction ComPPI
EIF6 ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNIK ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPL12 ACP1 25348397 N/A physical interaction ComPPI
CDK2 ACP1 25348397 N/A physical interaction ComPPI
EGFR ACP1 25348397 N/A physical interaction ComPPI
VHL ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EPHB1 ACP1 14525934 25348397 9499402 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CTNNB1 ACP1 12438242 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
VCAM1 ACP1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 ACP1 25348397 N/A physical interaction ComPPI
NR3C1 ACP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
BARD1 ACP1 25348397 N/A physical interaction ComPPI
DUSP2 ACP1 25348397 N/A physical interaction ComPPI
INSR ACP1 1304913 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TALDO1 ACP1 25348397 N/A physical interaction ComPPI
IKBKE ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GADD45GIP1 ACP1 25348397 N/A physical interaction ComPPI
FNBP1L ACP1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TES ACP1 25348397 N/A physical interaction ComPPI
MRPL20 ACP1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SFMBT1 ACP1 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TKTL2 ACP1 25348397 N/A physical interaction ComPPI
PPIL3 ACP1 25348397 N/A physical interaction ComPPI
TKT ACP1 25348397 N/A physical interaction ComPPI
GOT1 ACP1 25348397 N/A physical interaction ComPPI
KSR1 ACP1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
ADA ACP1 25348397 N/A physical interaction ComPPI
FN1 ACP1 25348397 N/A physical interaction ComPPI
EPB41 ACP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ACP1 ABRACL 25348397 N/A physical interaction ComPPI
ACP1 DNAJC13 25348397 N/A physical interaction ComPPI
ACP1 DUSP28 25348397 N/A physical interaction ComPPI
ACP1 POTEE 25348397 N/A physical interaction ComPPI
ACP1 ACTBL2 25348397 N/A physical interaction ComPPI
ACP1 SPTAN1 11971983 14525934 N/A experimental interaction detection,two hybrid HPRD
ACP1 FABP4 1304913 14525934 N/A experimental interaction detection HPRD
FYN ACP1 14525934 9038134 N/A experimental interaction detection HPRD
LCK ACP1 14525934 9038134 N/A experimental interaction detection HPRD
ACP1 ACP1 17353931 24234451 physical association anti bait coimmunoprecipitation IntAct
ACP2 ACP1 16866873 27898060 N/A N/A OmniPath
ACP1 SRC 19088431 27898060 N/A N/A OmniPath
LCK ACP1 10671492 10980198 16890200 17016520 27898060 9038134 N/A N/A OmniPath
ACP1 CTNNB1 12438242 16287083 27898060 stimulant N/A OmniPath
FYN ACP1 17016520 27898060 9038134 N/A N/A OmniPath
ACP1 EGFR 2787757 27898060 7532092 9784386 N/A N/A OmniPath
ACP1 PDGFRB 12149261 27898060 inhibition N/A OmniPath
ACP1 KDR 10608891 27898060 N/A N/A OmniPath
ACP1 LAT 17537991 27898060 N/A N/A OmniPath
ACP1 STAT5A 14637146 27898060 N/A N/A OmniPath
ACP1 AKT1 17353188 27898060 N/A N/A OmniPath
ACP1 PTK2 12055185 27898060 N/A N/A OmniPath
ACP1 INSR 1304913 17353188 27898060 9299573 N/A N/A OmniPath
ACP1 ZAP70 11976341 27898060 inhibition N/A OmniPath
ACP1 FCGR2A 17537991 27898060 N/A N/A OmniPath
ACP1 SLC4A1 2418829 27898060 N/A N/A OmniPath
ACP1 FABP4 1304913 27898060 N/A N/A OmniPath

Visualization










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