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GENE：AFG3L2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AFG3L2
FullNmae AFG3 like matrix AAA peptidase subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:315
EnsembleID ENSG00000141385
Uniprot Q9Y4W6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AFG3L2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
AFG3L2 GO:0004176,GO:0004222,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005743,GO:0005745,GO:0006508,GO:0006508,GO:0007409,GO:0007528,GO:0008053,GO:0008237,GO:0008270,GO:0016485,GO:0016540,GO:0016887,GO:0021675,GO:0033619,GO:0034982,GO:0036444,GO:0040014,GO:0042407,GO:0042552,GO:0051082,GO:0051560,GO:0055001,GO:0060013

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AFG3L2 hsa:10939 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 AFG3L2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 AFG3L2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR AFG3L2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AFG3L2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 AFG3L2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 AFG3L2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AFG3L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CHCHD2 AFG3L2 25348397 N/A physical interaction ComPPI
MAD2L2 AFG3L2 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
RPN1 AFG3L2 25348397 N/A physical interaction ComPPI
TOMM22 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PHC2 AFG3L2 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HIPK4 AFG3L2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SLC38A1 AFG3L2 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMMDC1 AFG3L2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 AFG3L2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NF2 AFG3L2 25348397 N/A physical interaction ComPPI
BTK AFG3L2 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
JUN AFG3L2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
NTRK1 AFG3L2 25348397 N/A physical interaction ComPPI
BTRC AFG3L2 25348397 N/A physical interaction ComPPI
PHB AFG3L2 25348397 N/A physical interaction ComPPI
TNFRSF1A AFG3L2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PDP2 AFG3L2 25348397 N/A physical interaction ComPPI
MAPK8IP2 AFG3L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATP1A1 AFG3L2 25348397 N/A physical interaction ComPPI
EGFR AFG3L2 25348397 N/A physical interaction ComPPI
TUBA1A AFG3L2 24234451 25348397 29568061 association pull down ComPPI,IntAct
PHB2 AFG3L2 25348397 N/A physical interaction ComPPI
RNF2 AFG3L2 25348397 N/A physical interaction ComPPI
USF1 AFG3L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC2 AFG3L2 25348397 N/A physical interaction ComPPI
RAC2 AFG3L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDK1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BECN1 AFG3L2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGS1 AFG3L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 AFG3L2 25348397 N/A physical interaction ComPPI
TOMM20 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AURKAIP1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SUZ12 AFG3L2 25348397 N/A physical interaction ComPPI
MED20 AFG3L2 25348397 N/A physical interaction ComPPI
NDUFA13 AFG3L2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELL2 AFG3L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPD1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HDHD5 AFG3L2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AK2 AFG3L2 25348397 N/A physical interaction ComPPI
ATP5F1A AFG3L2 25348397 N/A physical interaction ComPPI
CYLD AFG3L2 25348397 N/A physical interaction ComPPI
AIFM1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A3 AFG3L2 25348397 N/A physical interaction ComPPI
NEDD1 AFG3L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBA1C AFG3L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CYC1 AFG3L2 25348397 N/A physical interaction ComPPI
MGST3 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MTRES1 AFG3L2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRQ AFG3L2 25348397 N/A physical interaction ComPPI
AFG3L2 USP50 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 APP 25348397 N/A physical interaction ComPPI
AFG3L2 FBXO6 25348397 N/A physical interaction ComPPI
AFG3L2 CCDC8 25348397 N/A physical interaction ComPPI
AFG3L2 ATP5PB 25348397 N/A physical interaction ComPPI
AFG3L2 HSD17B12 25348397 N/A physical interaction ComPPI
AFG3L2 NDUFA9 25348397 N/A physical interaction ComPPI
AFG3L2 NDUFS1 25348397 N/A physical interaction ComPPI
AFG3L2 NDUFS8 25348397 N/A physical interaction ComPPI
AFG3L2 TMCO1 25348397 N/A physical interaction ComPPI
AFG3L2 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 GBA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 RBM45 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 MAIP1 25348397 N/A physical interaction ComPPI
AFG3L2 NDUFA4 25348397 N/A physical interaction ComPPI
AFG3L2 COQ9 25348397 N/A physical interaction ComPPI
AFG3L2 NMES1 25348397 N/A physical interaction ComPPI
AFG3L2 CISD3 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFG3L2 OCIAD1 25348397 N/A physical interaction ComPPI
AFG3L2 PTPMT1 25348397 N/A physical interaction ComPPI
AFG3L2 MIX23 25348397 N/A physical interaction ComPPI
AFG3L2 INTU 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFG3L2 RNF167 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
AFG3L2 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
AFG3L2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
AFG3L2 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AFG3L2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AFG3L2 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AFG3L2 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 OPA3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 COQ3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AFG3L2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TRMT61B AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AFG3L2 GJA10 24234451 30021884 physical association cross-linking study IntAct

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