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GENE：AHR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AHR
FullNmae aryl hydrocarbon receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:348
EnsembleID ENSG00000106546
Uniprot P35869

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AHR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AHR ferroptosis 38276975 Knocking out AHR, AIFM2, or ALDH1A3 reverses the inhibitory effect of IDA on ferroptosis and IDA-mediated tumor growth. retulator signature
AHR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AHR cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
AHR GO:0000785,GO:0000976,GO:0000976,GO:0000981,GO:0000987,GO:0001094,GO:0001223,GO:0001568,GO:0002819,GO:0002841,GO:0003677,GO:0003677,GO:0003700,GO:0004879,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005829,GO:0006355,GO:0006357,GO:0006357,GO:0006805,GO:0006915,GO:0007049,GO:0009410,GO:0009636,GO:0010468,GO:0017025,GO:0019933,GO:0030522,GO:0030888,GO:0032922,GO:0032991,GO:0034751,GO:0034752,GO:0034753,GO:0042803,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0050728,GO:0051879,GO:0061629,GO:0070888,GO:0071219,GO:0071320,GO:1904322,GO:1904613,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AHR hsa:196 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
AHR hsa:196 path:hsa04934 Cushing syndrome - Homo sapiens (human)
AHR hsa:196 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
AHR hsa:196 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AHR CXCL8 17823304 23180781 physical association electrophoretic mobility supershift assay InnateDB
AHR RELB 17823304 17900530 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
AHR ARNT 17823304 23180781 physical association anti tag coimmunoprecipitation InnateDB
AHR TNFSF13B 17823304 17900530 23180781 physical association electrophoretic mobility supershift assay InnateDB
AHR CXCL13 17823304 17900530 23180781 physical association electrophoretic mobility supershift assay InnateDB
AHR CCL1 17900530 23180781 physical association electrophoretic mobility supershift assay InnateDB
AHR IRF3 17900530 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR AHR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 AHR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP63 AHR 17521434 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 AHR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 AHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AURKAIP1 AHR 11469723 trascriptional regulation,stimulation inferred by curator TFlink
AIP AHR 11469723 trascriptional regulation,stimulation inferred by curator TFlink
ARNT AHR 18540824 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 AHR 10620335 trascriptional regulation,stimulation inferred by curator TFlink
ESRRA AHR 10620335 trascriptional regulation,stimulation inferred by curator TFlink
SMAD2 AHR 11259615 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 AHR 11259615 trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 AHR 11259615 trascriptional regulation,stimulation inferred by curator TFlink
SP1 AHR 16410262 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 AHR 16410262 trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 AHR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 AHR N/A rna interference,inhibition experimental interaction detection miRSponge
URS00002C0FCB AHR 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 AHR 19088304 23592263 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000001A7A AHR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037E170 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004977C5 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075ADAC AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004BCD9C AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5E03 AHR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 AHR 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 AHR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 AHR 25416803 26246194 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA AHR 22135298 phosphorylation N/A PhosphoSite
AHR AIP 25361965 interaction type N/A PTMCode2
AIP AHR 25361965 interaction type N/A PTMCode2
AHR ARNT2 25361965 interaction type N/A PTMCode2
ARNT2 AHR 25361965 interaction type N/A PTMCode2
AHR NCOA1 25361965 interaction type N/A PTMCode2
NCOA1 AHR 25361965 interaction type N/A PTMCode2
AHR NR2F1 25361965 interaction type N/A PTMCode2
NR2F1 AHR 25361965 interaction type N/A PTMCode2
AHR NRIP1 25361965 interaction type N/A PTMCode2
NRIP1 AHR 25361965 interaction type N/A PTMCode2
AHR HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 AHR 25361965 interaction type N/A PTMCode2
AHR ARNT 25361965 interaction type N/A PTMCode2
ARNT AHR 25361965 interaction type N/A PTMCode2
AHR AR 25361965 interaction type N/A PTMCode2
AR AHR 25361965 interaction type N/A PTMCode2
AHR CUL4B 25361965 interaction type N/A PTMCode2
CUL4B AHR 25361965 interaction type N/A PTMCode2
AHR RELA 25361965 interaction type N/A PTMCode2
RELA AHR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VIM AHR 25348397 N/A physical interaction ComPPI
PSMC3 AHR 25348397 N/A physical interaction ComPPI
NRIP1 AHR 10428779 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TAF9 AHR 25348397 N/A physical interaction ComPPI
SMAD4 AHR 25348397 N/A physical interaction ComPPI
TBL3 AHR 25348397 N/A physical interaction ComPPI
SP1 AHR 25348397 N/A physical interaction ComPPI
TBP AHR 14525934 25348397 8794892 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAF AHR 20676095 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RB1 AHR 10644764 11259609 14525934 24234451 25348397 27898060 9712901 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
GTF2F2 AHR 14525934 25348397 8794892 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AR AHR 14525934 17392787 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NCOA1 AHR 12024042 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EP300 AHR 10999956 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
COPS5 AHR 25348397 N/A physical interaction ComPPI
NFE2L2 AHR 25348397 N/A physical interaction ComPPI
RBX1 AHR 25348397 N/A physical interaction ComPPI
NCOR2 AHR 10395741 24234451 25348397 association,physical association coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
DAP3 AHR 10903152 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MED1 AHR 25348397 N/A physical interaction ComPPI
AIP AHR 16257957 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
HSP90AA1 AHR 14525934 25348397 7961671 9083006 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMARCA4 AHR 11805098 25348397 27898060 N/A physical interaction,in vitro ComPPI,OmniPath
PTGES3 AHR 11013261 11259606 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GNA13 AHR 25348397 N/A physical interaction ComPPI
RELA AHR 11114727 12181450 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
XPO1 AHR 12065584 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AHR CCNT1 12917420 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
AHR ARNTL 14525934 25348397 9079689 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
AHR NEDD8 12215427 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
AHR TAF7 14525934 25348397 8794892 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
AHR NCOA2 14525934 15641800 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AHR TAF4 14525934 15641800 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AHR CUL4B 14525934 17392787 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AHR NR2F1 10620335 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AHR ESR1 10620335 12612060 14525934 17392787 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AHR ARNT 10395741 11768231 12024042 14525934 24234451 25348397 7488247 7628454 8384309 9704006 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
AHR GTF2F1 25348397 N/A physical interaction ComPPI
AHR HSP90AA2P 25348397 N/A physical interaction ComPPI
AHR STUB1 12837759 17209571 25348397 27898060 N/A physical interaction ComPPI,OmniPath
AHR CTNNB1 19651607 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AHR DDB1 19651607 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AHR FOXA1 25348397 N/A physical interaction ComPPI
AHR IVNS1ABP 25348397 N/A physical interaction ComPPI
AHR BRCA1 25348397 N/A physical interaction ComPPI
AHR NCOA7 10395741 24234451 25348397 association,physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
AHR AK6 25348397 N/A physical interaction ComPPI
AHR TAF6 25348397 N/A physical interaction ComPPI
AHR ARNT2 25348397 N/A physical interaction ComPPI
AHR IQCN 25348397 N/A physical interaction ComPPI
AHR SIRT6 25348397 N/A physical interaction ComPPI
AHR TSPYL6 25348397 N/A physical interaction ComPPI
AHR TRIM25 25348397 N/A physical interaction ComPPI
AHR PSMC2 25348397 N/A physical interaction ComPPI
AHR PSMD5 25348397 N/A physical interaction ComPPI
AHR PSMD3 25348397 N/A physical interaction ComPPI
AHR PSMD4 25348397 N/A physical interaction ComPPI
AHR PSMC4 25348397 N/A physical interaction ComPPI
AHR AHR 10620335 14525934 N/A experimental interaction detection HPRD
RAB14 AHR 24234451 30021884 physical association cross-linking study IntAct
PRKCA AHR 11032419 15063792 27898060 N/A N/A OmniPath
CSNK2A1 AHR 14985336 27898060 N/A N/A OmniPath
RELB AHR 17823304 17900530 27898060 N/A N/A OmniPath

Visualization










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