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GENE：ALAS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ALAS1
FullNmae 5'-aminolevulinate synthase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:396
EnsembleID ENSG00000023330
Uniprot P13196

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ALAS1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ALAS1 GO:0003870,GO:0003870,GO:0005515,GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006782,GO:0006783,GO:0030170,GO:0042541,GO:0042802,GO:0048821,GO:1903412

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ALAS1 hsa:211 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
ALAS1 hsa:211 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
ALAS1 hsa:211 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ALAS1 hsa:211 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXO1 ALAS1 10364186 15668399 16122419 19449109 25464856 26192618 interaction type N/A ACSN
PPARGC1A ALAS1 10364186 15668399 16122419 19449109 25464856 26192618 interaction type N/A ACSN
ALAS1 BCL7A 23180781 25416956 physical association two hybrid InnateDB
ALAS1 PPL 23180781 25416956 physical association two hybrid InnateDB
ALAS1 TCEA2 23180781 25416956 physical association two hybrid InnateDB
ALAS1 TMSB4X 23180781 25416956 physical association two hybrid InnateDB
ALAS1 WIPF1 23180781 25416956 physical association two hybrid InnateDB
ALAS1 ZNF175 23180781 25416956 physical association two hybrid InnateDB
ALAS1 TMSB10 23180781 25416956 physical association two hybrid InnateDB
ALAS1 USP20 23180781 25416956 physical association two hybrid InnateDB
ALAS1 ZFYVE26 23180781 25416956 physical association two hybrid InnateDB
ALAS1 POLDIP2 23180781 25416956 physical association two hybrid InnateDB
ALAS1 CCHCR1 23180781 25416956 physical association two hybrid InnateDB
ALAS1 GNL3L 23180781 25416956 physical association two hybrid InnateDB
ALAS1 C2ORF42 23180781 25416956 physical association two hybrid InnateDB
ALAS1 EP400 23180781 25416956 physical association two hybrid InnateDB
ALAS1 SH2D4A 23180781 25416956 physical association two hybrid InnateDB
ALAS1 CERK 23180781 25416956 physical association two hybrid InnateDB
ALAS1 TTC23 23180781 25416956 physical association two hybrid InnateDB
ALAS1 CDC73 23180781 25416956 physical association two hybrid InnateDB
ALAS1 ZMAT1 23180781 25416956 physical association two hybrid InnateDB
ALAS1 LONRF1 23180781 25416956 physical association two hybrid InnateDB
ALAS1 SNX20 23180781 25416956 physical association two hybrid InnateDB
ALAS1 DUSP19 23180781 25416956 physical association two hybrid InnateDB
ALAS1 TEKT4 23180781 25416956 physical association two hybrid InnateDB
ALAS1 KLHL35 23180781 25416956 physical association two hybrid InnateDB
ALAS1 RTL8B 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ALAS1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ALAS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ALAS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ALAS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ALAS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ALAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC ALAS1 15123725 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE ALAS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 ALAS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RTL8B ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF564 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TEKT4 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZFYVE26 ALAS1 25348397 N/A physical interaction ComPPI
UTP14C ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPL ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNRPB2 ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC73 ALAS1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
USP20 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TMSB4X ALAS1 25348397 N/A physical interaction ComPPI
CDKN1A ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TK1 ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZNF175 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LRRC45 ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZMAT1 ALAS1 25348397 N/A physical interaction ComPPI
GNL3L ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TMSB10 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3CB ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
POLDIP2 ALAS1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAP1B ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAMK2D ALAS1 25348397 N/A physical interaction ComPPI
RNF168 ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUMO2 ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VHL ALAS1 25348397 N/A physical interaction ComPPI
RCHY1 ALAS1 25348397 N/A physical interaction ComPPI
CDK5 ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FDPS ALAS1 25348397 N/A physical interaction ComPPI
WIPF1 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PDK1 ALAS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ALAS1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
STAMBP ALAS1 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FBXL8 ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DUSP19 ALAS1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAP2 ALAS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPD1 ALAS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUDT3 ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SH2D4A ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNX20 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL7A ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KLHL35 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NDUFS6 ALAS1 25348397 N/A physical interaction ComPPI
MGST3 ALAS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HMGCL ALAS1 25348397 N/A physical interaction ComPPI
C8ORF33 ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ECHDC2 ALAS1 25348397 N/A physical interaction ComPPI
ALAS1 PLAU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ALAS1 TCEA2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 CCHCR1 25348397 N/A physical interaction ComPPI
ALAS1 EP400 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 CERK 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 TTC23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 LONRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 MTFR2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALAS1 MOV10 25348397 N/A physical interaction ComPPI
ALAS1 NXF1 25348397 N/A physical interaction ComPPI
ALAS1 OXLD1 25348397 N/A physical interaction ComPPI
ALAS1 TMOD3 25348397 N/A physical interaction ComPPI
ALAS1 THEM4 25348397 N/A physical interaction ComPPI
ALAS1 MCAT 25348397 N/A physical interaction ComPPI
ALAS1 TMOD4 25348397 N/A physical interaction ComPPI
ALAS1 PCK2 25348397 N/A physical interaction ComPPI
ALAS1 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
ALAS1 KIF9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALAS1 HSBP1L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALAS1 MTSS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALAS1 GRXCR1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALAS1 COBL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALAS1 WASHC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRMT61B ALAS1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
C2ORF42 ALAS1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSCB ALAS1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ALAS1 ALAS1 24234451 25416956 physical association two hybrid array,two hybrid prey pooling approach IntAct
OXTR ALAS1 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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