GENE：AOC3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AOC3 |
| FullNmae | amine oxidase copper containing 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:550 |
| EnsembleID | ENSG00000131471 |
| Uniprot | Q16853 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AOC3 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AOC3 | cuproptosis | 38006800 | Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. | cuproptosis-related genes |
| AOC3 | cuproptosis | 38006800 | As for CRG, 19 CRGs(CP,CD274,PDE3B,DLAT,VEGFA,DBH,COX11,COA6,PDK1,SLC31A2,UBE2D1,UlK1,SLC25A3,MTF1,UBE2D3,SLC31A1,MAP2K1,AOC3,CCL8) were significantly differentially expressed in the Control and sepsis induced cardiotoxicity groups in GSE44363 | cuproptosis-related genes |
| AOC3 | cuproptosis | 38348451 | AOC3 encodes a copper-dependent enzyme involved in the metabolism of amines. Its role in cuproptosis may be linked to its participation in oxidative reactions. | CRGs in the cuproptosis pathway |
| AOC3 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| AOC3 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| AOC3 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AOC3 | GO:0005507,GO:0005507,GO:0005509,GO:0005515,GO:0005737,GO:0005769,GO:0005769,GO:0005783,GO:0005783,GO:0005794,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005902,GO:0006954,GO:0007155,GO:0008131,GO:0009308,GO:0009308,GO:0009986,GO:0016020,GO:0042802,GO:0046677,GO:0046677,GO:0046982,GO:0048038,GO:0052593,GO:1902283,GO:1902283 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AOC3 | hsa:8639 | path:hsa00260 | Glycine, serine and threonine metabolism - Homo sapiens (human) |
| AOC3 | hsa:8639 | path:hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| AOC3 | hsa:8639 | path:hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| AOC3 | hsa:8639 | path:hsa00410 | beta-Alanine metabolism - Homo sapiens (human) |
| AOC3 | hsa:8639 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | AOC3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | AOC3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AOC3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AOC3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AOC3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | AOC3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000235862 | AOC3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | AOC3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | AOC3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | AOC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D6605 | AOC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | AOC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D69F6 | AOC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SGTA | AOC3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| LMNA | AOC3 | 25348397 | N/A | physical interaction | ComPPI |
| VAV1 | AOC3 | 1375396 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| AOC3 | SLC9A1 | 25348397 | N/A | physical interaction | ComPPI |
| AOC3 | ERF | 25348397 | N/A | physical interaction | ComPPI |
| AOC3 | MYBPC2 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| AOC3 | CREB3L1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| AOC3 | STX1A | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |