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GENE：AP1S1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AP1S1
FullNmae adaptor related protein complex 1 subunit sigma 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:559
EnsembleID ENSG00000106367
Uniprot P61966

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AP1S1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
AP1S1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
AP1S1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AP1S1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Copper metabolism disease related genes

Go Annotation:

GeneSymbol Go id
AP1S1 GO:0000139,GO:0005765,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006898,GO:0009615,GO:0016020,GO:0016192,GO:0016192,GO:0030121,GO:0030121,GO:0030659,GO:0032588,GO:0032588,GO:0035615,GO:0043231,GO:0043231,GO:0060155,GO:0110010,GO:1903232

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AP1S1 hsa:1174 path:hsa04142 Lysosome - Homo sapiens (human)
AP1S1 hsa:1174 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 AP1S1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 AP1S1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 AP1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AP1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AP1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 AP1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AP1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 AP1S1 21282569 25416803 mrna cleavage,inhibition array technology TarBase
URS000025EABA AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065FDF AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032EF64 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237CBD AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000122ED0 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000324096 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029979D AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000B1C9 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000031E12 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A07C1 AP1S1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000EC1BE AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 AP1S1 21572407 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000913AC AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD AP1S1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D AP1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AP1S1 AP1B1 25361965 interaction type N/A PTMCode2
AP1B1 AP1S1 25361965 interaction type N/A PTMCode2
AP1S2 AP1S1 25361965 interaction type N/A PTMCode2
AP1S1 AP1S2 25361965 interaction type N/A PTMCode2
AP1M2 AP1S1 25361965 interaction type N/A PTMCode2
AP1S1 AP1M2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KEAP1 AP1S1 25348397 N/A physical interaction ComPPI
RAB10 AP1S1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AP1G2 AP1S1 25348397 N/A two hybrid,physical interaction ComPPI
AP1M1 AP1S1 25348397 N/A physical interaction ComPPI
AP1M2 AP1S1 10535737 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HNRNPL AP1S1 25348397 N/A physical interaction ComPPI
AP2A2 AP1S1 11707398 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
XPO1 AP1S1 25348397 N/A physical interaction ComPPI
AP2B1 AP1S1 25348397 N/A physical interaction ComPPI
AP1B1 AP1S1 24234451 24843023 25348397 physical association molecular sieving,x-ray crystallography,physical interaction ComPPI,IntAct
AP1G1 AP1S1 14525934 25348397 9733768 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EGFR AP1S1 25348397 N/A physical interaction ComPPI
ELOB AP1S1 25348397 N/A physical interaction ComPPI
SLC16A1 AP1S1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBA1 AP1S1 25348397 N/A physical interaction ComPPI
AP2M1 AP1S1 25348397 N/A physical interaction ComPPI
TRIM25 AP1S1 25348397 N/A physical interaction ComPPI
AP1S1 SEC61A1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AP1S1 ARMC6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AP1S1 MOV10 25348397 N/A physical interaction ComPPI
AP1S1 GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP1S1 RHOU 25348397 N/A physical interaction ComPPI
AP1S1 AP1S2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AP1S1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AP1S1 AP1S1 14525934 9733768 N/A two hybrid HPRD

Visualization










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