GENE：MAP3K13
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAP3K13 |
| FullNmae | mitogen-activated protein kinase kinase kinase 13 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6852 |
| EnsembleID | ENSG00000073803 |
| Uniprot | O43283 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAP3K13 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAP3K13 | GO:0004674,GO:0004674,GO:0004706,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007254,GO:0007254,GO:0007254,GO:0014042,GO:0016020,GO:0018105,GO:0019899,GO:0019901,GO:0042802,GO:0042803,GO:0043507,GO:0043539,GO:0045773,GO:0046777,GO:0046872,GO:0051092,GO:0051403,GO:0106137,GO:0106310,GO:0150012,GO:1905492 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAP3K13 | hsa:9175 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAP3K13 | PRDX3 | 12492477 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IKBKB | MAP3K13 | 12492477 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAP3K13 | MAP2K7 | 11726277 23331499 | stimulation | N/A | SignaLink |
| MAP3K13 | MAPK8IP1 | 11726277 23331499 | interaction type | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAP3K13 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | MAP3K13 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MAP3K13 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | MAP3K13 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MAP3K13 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| INPPL1 | MAP3K13 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-DRB3 | MAP3K13 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| IKBKB | MAP3K13 | 12492477 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8IP1 | MAP3K13 | 11726277 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAP2K7 | MAP3K13 | 25348397 | N/A | physical interaction | ComPPI |
| STAT3 | MAP3K13 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MAP3K13 | PRDX3 | 12492477 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
| MAP3K13 | GLO1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MAP3K13 | H2AC20 | 25348397 | N/A | physical interaction | ComPPI |
| MAP3K13 | KLHL20 | 25348397 | N/A | physical interaction | ComPPI |
| MAP3K13 | MAP3K13 | 11163770 14525934 24234451 | physical association | anti tag coimmunoprecipitation,experimental interaction detection | HPRD,IntAct |
| MAP3K13 | MAPK8IP1 | 11726277 27898060 | N/A | N/A | OmniPath |
| MAP3K13 | MAP2K7 | 11726277 27898060 | stimulant | N/A | OmniPath |
| IKBKB | MAP3K13 | 12492477 27898060 | N/A | N/A | OmniPath |
| MAP3K13 | PRDX3 | 12492477 27898060 | N/A | N/A | OmniPath |