GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
API5
FullNmae
apoptosis inhibitor 5
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:594
EnsembleID
ENSG00000166181
Uniprot
Q9BZZ5
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
API5
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
API5
GO:0003723,GO:0003723,GO:0005515,GO:0005634,GO:0005634,GO:0005681,GO:0005737,GO:0016020,GO:0016607,GO:0017134,GO:0043066,GO:0043066,GO:0043066,GO:0043066,GO:0044346,GO:2000270
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
ETS1
API5
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
SMARCA4
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F4
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXP1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
GATA2
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
PRDM14
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
RUNX1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TAL1
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TP53
API5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS0000184017
API5
N/A
18319255
rna interference,inhibition
experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay
miRSponge
URS0000184017
API5
18319255
22328513
22743998
25416803
mrna cleavage,inhibition
western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay
miRDeathDB,TarBase
URS0000345DEB
API5
20371350
25416803
mrna cleavage,inhibition
nucleotide sequence identification
TarBase
URS000032FC1A
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000C5BAA
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000215483
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000AA464
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00004818BD
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000003575B
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00004AC389
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000016D2D4
API5
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
SNW1
API5
20467437
24234451
25348397
association
anti bait coimmunoprecipitation,physical interaction
ComPPI,IntAct
CDC5L
API5
25348397
N/A
physical interaction
ComPPI
GLRX3
API5
25348397
N/A
physical interaction
ComPPI
OXSR1
API5
25348397
N/A
physical interaction
ComPPI
BAG3
API5
25348397
N/A
physical interaction
ComPPI
IMPDH2
API5
25348397
N/A
physical interaction
ComPPI
TP53BP1
API5
24234451
25348397
29656893
association
proximity-dependent biotin identification
ComPPI,IntAct
MCM5
API5
25348397
N/A
physical interaction
ComPPI
DCUN1D1
API5
25348397
N/A
physical interaction
ComPPI
RAD21
API5
25348397
N/A
physical interaction
ComPPI
EZH2
API5
25348397
N/A
physical interaction
ComPPI
DLD
API5
24234451
25348397
29128334
association
cross-linking study,physical interaction
ComPPI,IntAct
NTRK1
API5
25348397
N/A
physical interaction
ComPPI
XRN2
API5
25348397
N/A
physical interaction
ComPPI
LASP1
API5
25348397
N/A
physical interaction
ComPPI
EIF6
API5
25348397
N/A
physical interaction
ComPPI
PPP2R5C
API5
25348397
N/A
physical interaction
ComPPI
EWSR1
API5
25348397
N/A
physical interaction
ComPPI
PPP2R5E
API5
25348397
N/A
physical interaction
ComPPI
EGFR
API5
25348397
N/A
physical interaction
ComPPI
HTT
API5
17500595
24234451
25348397
physical association
two hybrid
ComPPI,IntAct
STAT6
API5
25348397
N/A
physical interaction
ComPPI
EED
API5
25348397
N/A
physical interaction
ComPPI
H3C1
API5
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
STK39
API5
25348397
N/A
physical interaction
ComPPI
TRIM25
API5
25348397
N/A
physical interaction
ComPPI
ACIN1
API5
19387494
24234451
25348397
27898060
colocalization,physical association
anti bait coimmunoprecipitation,fluorescence microscopy
ComPPI,IntAct,OmniPath
ELAVL1
API5
25348397
N/A
physical interaction
ComPPI
MLH1
API5
25348397
N/A
physical interaction
ComPPI
DDX39A
API5
25348397
N/A
physical interaction
ComPPI
SOD1
API5
24234451
25348397
29128334
association
cross-linking study,physical interaction
ComPPI,IntAct
PRKAB1
API5
17353931
24234451
25348397
physical association
anti bait coimmunoprecipitation
ComPPI,IntAct
GTF3C4
API5
25348397
N/A
physical interaction
ComPPI
FGF2
API5
11075807
14525934
25348397
27898060
N/A
two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid
ComPPI,HPRD,OmniPath
EHD1
API5
25348397
N/A
physical interaction
ComPPI
CCND2
API5
25348397
N/A
physical interaction
ComPPI
DRG2
API5
25348397
N/A
physical interaction
ComPPI
POU5F1
API5
25348397
N/A
physical interaction
ComPPI
API5
ADSL
25348397
N/A
physical interaction
ComPPI
API5
TTI1
25348397
N/A
physical interaction
ComPPI
API5
OTUB1
24234451
25348397
26752685
association
anti tag coimmunoprecipitation
ComPPI,IntAct
EBNA1BP2
API5
25348397
N/A
physical interaction
ComPPI
API5
SOCS6
24234451
30021884
physical association
cross-linking study
IntAct
DDX39B
API5
24234451
30021884
physical association
cross-linking study
IntAct
API5
LTV1
24234451
30021884
physical association
cross-linking study
IntAct
Visualization