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GENE：ARHGEF39

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARHGEF39
FullNmae Rho guanine nucleotide exchange factor 39
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25909
EnsembleID ENSG00000137135
Uniprot Q8N4T4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARHGEF39 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ARHGEF39 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
ARHGEF39 cuproptosis 36313444 Finally, seven copper death genes related to lung adenocarcinoma were screened out, including ARHGEF39, EFCC1, SERPIND1, INSL4, ANLN, RHOV and CCL20. copper death genes

Go Annotation:

GeneSymbol Go id
ARHGEF39 GO:0005085,GO:0005515,GO:0005886,GO:0005886,GO:0030335,GO:0030335

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 ARHGEF39 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ARHGEF39 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A ARHGEF39 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ARHGEF39 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001AFC71 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ARHGEF39 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 ARHGEF39 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040EC3B ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000034979B ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000D5FFC ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237AF9 ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C5969 ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003758F0 ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001067D1 ARHGEF39 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RBPMS ARHGEF39 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ZNRD2 ARHGEF39 25348397 N/A physical interaction ComPPI
TIFA ARHGEF39 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DVL2 ARHGEF39 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CALCOCO2 ARHGEF39 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct

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