Gene Information gene info

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GENE：ATIC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATIC
FullNmae 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:794
EnsembleID ENSG00000138363
Uniprot P31939

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATIC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATIC cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ATIC GO:0003360,GO:0003937,GO:0003937,GO:0004643,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0006139,GO:0006177,GO:0006189,GO:0006189,GO:0006189,GO:0010035,GO:0016020,GO:0021549,GO:0021987,GO:0031100,GO:0042803,GO:0044208,GO:0045296,GO:0046452,GO:0046654,GO:0070062,GO:0097294,GO:0098761

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATIC hsa:471 path:hsa00230 Purine metabolism - Homo sapiens (human)
ATIC hsa:471 path:hsa00670 One carbon pool by folate - Homo sapiens (human)
ATIC hsa:471 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ATIC hsa:471 path:hsa01523 Antifolate resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 ATIC 16009940 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ATIC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATIC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ATIC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATIC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATIC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATIC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000079D48 ATIC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 ATIC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000072E4C ATIC 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 ATIC 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D ATIC 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC ATIC 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB ATIC 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F ATIC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AC389 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000003FD55 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B0920 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000331800 ATIC 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ALK ATIC 22135298 phosphorylation N/A PhosphoSite
ATIC ATIC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNRPA ATIC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 ATIC 25348397 N/A physical interaction ComPPI
TRAF6 ATIC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLNS1A ATIC 25348397 N/A physical interaction ComPPI
CRK ATIC 25348397 N/A physical interaction ComPPI
RBBP6 ATIC 25348397 N/A physical interaction ComPPI
CTBP1 ATIC 25348397 N/A physical interaction ComPPI
U2AF2 ATIC 25348397 N/A physical interaction ComPPI
PGM1 ATIC 25348397 N/A physical interaction ComPPI
NTRK1 ATIC 25348397 N/A physical interaction ComPPI
CDH1 ATIC 25348397 N/A physical interaction ComPPI
JAK1 ATIC 25348397 N/A physical interaction ComPPI
KCNAB1 ATIC 25348397 N/A physical interaction ComPPI
KCNAB2 ATIC 25348397 N/A physical interaction ComPPI
TXN ATIC 25348397 N/A physical interaction ComPPI
PAFAH1B1 ATIC 25348397 N/A physical interaction ComPPI
SUMO2 ATIC 25348397 N/A physical interaction ComPPI
NAE1 ATIC 25348397 N/A physical interaction ComPPI
SPR ATIC 25348397 N/A physical interaction ComPPI
CDK2 ATIC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR ATIC 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
YWHAE ATIC 25348397 N/A physical interaction ComPPI
VHL ATIC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSTPIP1 ATIC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPB1 ATIC 25348397 N/A physical interaction ComPPI
RTN4 ATIC 25348397 N/A physical interaction ComPPI
MSN ATIC 25348397 N/A physical interaction ComPPI
DNM1L ATIC 25348397 N/A physical interaction ComPPI
CUL7 ATIC 25348397 N/A physical interaction ComPPI
PLIN3 ATIC 25348397 N/A physical interaction ComPPI
UBA1 ATIC 25348397 N/A physical interaction ComPPI
CAPN2 ATIC 25348397 N/A physical interaction ComPPI
INSR ATIC 25348397 N/A physical interaction ComPPI
MTNR1A ATIC 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
NSFL1C ATIC 25348397 N/A physical interaction ComPPI
ATIC IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC RADIL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC STOM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC HNRNPDL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC NDUFAF1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC CMBL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATIC SIRT7 25348397 N/A physical interaction ComPPI
ATIC TYMS 25348397 N/A physical interaction ComPPI
ATIC OXCT1 25348397 N/A physical interaction ComPPI
ATIC TARDBP 25348397 N/A physical interaction ComPPI
ATIC ASB6 25348397 N/A physical interaction ComPPI
ATIC CTH 25348397 N/A physical interaction ComPPI
ATIC FH 25348397 N/A physical interaction ComPPI
ATIC GMDS 25348397 N/A physical interaction ComPPI
ATIC MCTS1 25348397 N/A physical interaction ComPPI
ATIC STK26 25348397 N/A physical interaction ComPPI
ATIC MYO1E 25348397 N/A physical interaction ComPPI
ATIC OGFOD1 25348397 N/A physical interaction ComPPI
ATIC PAPSS1 25348397 N/A physical interaction ComPPI
ATIC PTMA 25348397 N/A physical interaction ComPPI
ATIC TATDN1 25348397 N/A physical interaction ComPPI
ATIC IPO5 25348397 N/A physical interaction ComPPI
ATIC PLPBP 25348397 N/A physical interaction ComPPI
ATIC ALDH16A1 25348397 N/A physical interaction ComPPI
ATIC ACOT13 25348397 N/A physical interaction ComPPI
ATIC ADSL 25348397 N/A physical interaction ComPPI
ATIC ARMT1 25348397 N/A physical interaction ComPPI
ATIC DERA 25348397 N/A physical interaction ComPPI
ATIC GLO1 25348397 N/A physical interaction ComPPI
ATIC PAICS 25348397 N/A physical interaction ComPPI
ATIC SHMT1 25348397 N/A physical interaction ComPPI
ATIC EEF2 25348397 N/A physical interaction ComPPI
ATIC ELAC2 25348397 N/A physical interaction ComPPI
ATIC GART 25348397 N/A physical interaction ComPPI
ATIC TRNT1 25348397 N/A physical interaction ComPPI
ATIC SERPINB5 25348397 N/A physical interaction ComPPI
ATIC ME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATIC PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
ATIC OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
AHCY ATIC 25348397 N/A physical interaction ComPPI
ISOC1 ATIC 25348397 N/A physical interaction ComPPI
ATIC ATIC 11096114 14525934 9598063 N/A experimental interaction detection HPRD
ISG15 ATIC 16009940 27898060 N/A N/A OmniPath

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