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GENE：PFN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PFN2
FullNmae profilin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8882
EnsembleID ENSG00000070087
Uniprot P35080

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PFN2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PFN2 GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005737,GO:0005856,GO:0010633,GO:0016887,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0032233,GO:0032233,GO:0032781,GO:0033138,GO:0050821,GO:0051496,GO:0070062,GO:0098685,GO:0098793,GO:0098794,GO:0098885,GO:0098978,GO:0099171,GO:1900028,GO:2000300

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PFN2 hsa:5217 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PFN2 hsa:5217 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PFN2 hsa:5217 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PFN2 hsa:5217 path:hsa05131 Shigellosis - Homo sapiens (human)
PFN2 hsa:5217 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PFN2 SNTA1 15123239 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
AR PFN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PFN2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PFN2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PFN2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001A405B PFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075AB0E PFN2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001938D9 PFN2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PFN2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PFN2 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A PFN2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PFN2 VASP 25361965 interaction type N/A PTMCode2
VASP PFN2 25361965 interaction type N/A PTMCode2
PFN2 FHOD1 25361965 interaction type N/A PTMCode2
FHOD1 PFN2 25361965 interaction type N/A PTMCode2
PFN2 MYPOP 25361965 interaction type N/A PTMCode2
MYPOP PFN2 25361965 interaction type N/A PTMCode2
PFN2 DNM1 25361965 interaction type N/A PTMCode2
DNM1 PFN2 25361965 interaction type N/A PTMCode2
PFN2 PFN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAD2L2 PFN2 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
DHX15 PFN2 25348397 N/A physical interaction ComPPI
SGTA PFN2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
VASP PFN2 10882740 14525934 25348397 27898060 7737110 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ACTG1 PFN2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRAF6 PFN2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 PFN2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTB PFN2 10600384 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ROCK1 PFN2 14517206 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MCM2 PFN2 25348397 N/A physical interaction ComPPI
EVL PFN2 10945997 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SYN1 PFN2 14525934 25348397 9463375 N/A experimental interaction detection,in vitro ComPPI,HPRD
DLD PFN2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PLAUR PFN2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PTPN1 PFN2 25348397 N/A physical interaction ComPPI
DIAPH1 PFN2 25348397 N/A physical interaction ComPPI
PFN2 DNM1 14525934 16319076 25348397 27898060 9463375 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PFN2 FHOD1 12677009 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PFN2 EEF1A1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 TERF1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 SEPTIN5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 RPS10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 DLST 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 RAP1GAP 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 PTPRS 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 CCDC113 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 IVNS1ABP 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 RNF146 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PFN2 WDR33 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 ANTKMT 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 FLT3LG 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 DDX11 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PFN2 GOLGB1 14525934 16169070 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 NDUFB8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN2 MYPOP 14525934 15615774 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
PFN2 HTT 14525934 15383276 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
PFN2 SIN3A 25348397 N/A physical interaction ComPPI
PFN2 DDX12P 25348397 N/A physical interaction ComPPI
PFN2 EEF1A1P5 25348397 N/A physical interaction ComPPI
PFN2 FMNL1 25348397 N/A physical interaction ComPPI
PFN2 HMGCS1 25348397 N/A physical interaction ComPPI
PFN2 SNTA1 25348397 N/A physical interaction ComPPI
PFN2 ASB12 25348397 N/A physical interaction ComPPI
PFN2 MTMR8 25348397 N/A physical interaction ComPPI
PFN2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFN2 NAA80 25348397 N/A physical interaction ComPPI
PFN2 INF2 25348397 N/A physical interaction ComPPI
PFN2 PALLD 25348397 N/A physical interaction ComPPI
PFN2 ACTBL2 25348397 N/A physical interaction ComPPI
PFN2 ACTA2 25348397 N/A physical interaction ComPPI
PFN2 BLVRB 25348397 N/A physical interaction ComPPI
PFN2 ENAH 25348397 N/A physical interaction ComPPI
PFN2 GSN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PFN2 EIF3K 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PFN2 ARPC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PFN2 TRIM25 25348397 N/A physical interaction ComPPI
PFN2 G3BP1 25348397 N/A physical interaction ComPPI
PFN2 MUC7 16203048 24234451 25348397 physical association two hybrid ComPPI,IntAct
PFN2 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFN2 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFN2 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFN2 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFN2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PFN2 MSANTD3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
WASF1 PFN2 24234451 25348397 9843499 physical association pull down ComPPI,IntAct
IK PFN2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DNALI1 PFN2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SESTD1 PFN2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PFN2 PFN2 10600384 14525934 N/A experimental interaction detection HPRD

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