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GENE：BCL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCL2
FullNmae BCL2 apoptosis regulator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:990
EnsembleID ENSG00000171791
Uniprot P10415

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCL2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2 necroptosis 33186708 Overall, we conclude that RSV could relieve CT-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in CIK cells. retulator signature
BCL2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BCL2 mpt 19228691 Therefore, we here describe a novel function of CypD as a Bcl2 collaborator and an inhibitor of cytochrome c release from mitochondria independent of the MPT. This function of CypD may explain the anti-apoptotic effect of this protein observed in various cancer cells. retulator signature
BCL2 mitotic_cd 27887793 Our results showed that quercetin triggered BCL2/BAX-mediated apoptosis, as well as necrosis and mitotic catastrophe, and inhibited the migratory potential of A549 cells. retulator signature
BCL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2 autophagy 31776982 Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. retulator signature
BCL2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BCL2 apoptosis 26587781 These proteins aim to restore homeostasis, but they can also induce cell death, which has been shown to occur by necroptosis and, more commonly, through the regulation of Bcl-2 family proteins (Bim, Noxa and Puma) that leads to mitochondrial apoptosis. retulator signature
BCL2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BCL2 anoikis 30139926 In healthy cells, anoikis is mostly governed by B-cell lymphoma-2 (BCL2) protein family members. retulator signature
BCL2 cuproptosis 36072790 CYP2D6,聽DAPK2,聽BCL2,聽RANTES, and聽IL-8聽are all related to the redox characteristics of copper. redox characteristics of copper

Go Annotation:

GeneSymbol Go id
BCL2 GO:0000082,GO:0000209,GO:0001503,GO:0001541,GO:0001656,GO:0001658,GO:0001662,GO:0001782,GO:0001783,GO:0001836,GO:0001836,GO:0001952,GO:0002020,GO:0002320,GO:0002326,GO:0002903,GO:0002931,GO:0003014,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005783,GO:0005789,GO:0005829,GO:0006582,GO:0006808,GO:0006915,GO:0006959,GO:0006974,GO:0007015,GO:0007409,GO:0007565,GO:0008284,GO:0008584,GO:0008625,GO:0008630,GO:0008631,GO:0009314,GO:0009410,GO:0009410,GO:0009636,GO:0009791,GO:0010039,GO:0010224,GO:0010332,GO:0010468,GO:0010507,GO:0010507,GO:0010523,GO:0010559,GO:0014031,GO:0014042,GO:0014909,GO:0014911,GO:0015267,GO:0016020,GO:0016248,GO:0021747,GO:0022612,GO:0022898,GO:0030279,GO:0030307,GO:0030308,GO:0030318,GO:0030336,GO:0030890,GO:0031069,GO:0031103,GO:0031625,GO:0031647,GO:0031965,GO:0032469,GO:0032835,GO:0032848,GO:0032880,GO:0032991,GO:0033028,GO:0033033,GO:0033077,GO:0033138,GO:0033687,GO:0033689,GO:0034097,GO:0035094,GO:0035265,GO:0040018,GO:0042100,GO:0042149,GO:0042542,GO:0042551,GO:0042802,GO:0042803,GO:0043029,GO:0043065,GO:0043066,GO:0043066,GO:0043066,GO:0043200,GO:0043209,GO:0043375,GO:0043524,GO:0043565,GO:0043583,GO:0045069,GO:0045636,GO:0046666,GO:0046671,GO:0046902,GO:0046930,GO:0046982,GO:0046982,GO:0048041,GO:0048536,GO:0048538,GO:0048546,GO:0048599,GO:0048741,GO:0048743,GO:0048753,GO:0048864,GO:0048873,GO:0050853,GO:0051384,GO:0051402,GO:0051434,GO:0051607,GO:0051721,GO:0051881,GO:0051902,GO:0051924,GO:0060090,GO:0060218,GO:0060402,GO:0070059,GO:0070231,GO:0070233,GO:0071310,GO:0071456,GO:0072593,GO:0097048,GO:0097049,GO:0097138,GO:0097192,GO:0098609,GO:0140297,GO:1902166,GO:1904019,GO:1904036,GO:2000134,GO:2000378,GO:2000669,GO:2000672,GO:2000811,GO:2001234,GO:2001240,GO:2001243,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCL2 hsa:596 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
BCL2 hsa:596 path:hsa01522 Endocrine resistance - Homo sapiens (human)
BCL2 hsa:596 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
BCL2 hsa:596 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04140 Autophagy - animal - Homo sapiens (human)
BCL2 hsa:596 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
BCL2 hsa:596 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04210 Apoptosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
BCL2 hsa:596 path:hsa04217 Necroptosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
BCL2 hsa:596 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04510 Focal adhesion - Homo sapiens (human)
BCL2 hsa:596 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
BCL2 hsa:596 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
BCL2 hsa:596 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
BCL2 hsa:596 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
BCL2 hsa:596 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
BCL2 hsa:596 path:hsa05131 Shigellosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa05132 Salmonella infection - Homo sapiens (human)
BCL2 hsa:596 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa05152 Tuberculosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa05161 Hepatitis B - Homo sapiens (human)
BCL2 hsa:596 path:hsa05162 Measles - Homo sapiens (human)
BCL2 hsa:596 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
BCL2 hsa:596 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
BCL2 hsa:596 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
BCL2 hsa:596 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
BCL2 hsa:596 path:hsa05210 Colorectal cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05215 Prostate cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05226 Gastric cancer - Homo sapiens (human)
BCL2 hsa:596 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
BCL2 hsa:596 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2 BAX 11704864 16227588 17446862 17891140 20709625 21641962 22039431 22705850 23064052 23180781 23377657 23430059 23850759 26192618 7644501 8358790 8929532 9872359 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
BCL2 BBC3 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
BCL2 BAK1 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
BCL2 TMBIM6 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 9660918 association N/A ACSN
BCL2 BECN1 10604474 11704864 16179260 17106237 17438366 17446862 17891140 18612260 19050071 19273585 19347031 20622903 22039431 22885520 23064052 23180781 23377657 23430059 23850759 26192618 27754749 8929532 9765397 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,tandem affinity purification ACSN,InnateDB
BCL2 UVRAG 10604474 11704864 16179260 17106237 17446862 17891140 18612260 22039431 22885520 23064052 23377657 23430059 23850759 26192618 27754749 8929532 9765397 interaction type N/A ACSN
BCL2 BCL2L11 10198631 11704864 15486085 15724238 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 9430630 association N/A ACSN
BCL2 BAD 10826997 10949026 11342610 11704864 12107820 12175651 12444011 12767520 15849194 16931767 17446862 19030972 19641503 21540285 22039431 23064052 23180781 23377657 23430059 23850759 26192618 8929532 9346240 association,physical association gst pull down ACSN,InnateDB
BCL2 BMF 11546872 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
BCL2 AMBRA1 11704864 17446862 21358617 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
MYC BCL2 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 26192618 28536364 interaction type N/A ACSN
NFKB1 BCL2 11313951 11704864 21725609 23178297 23572150 26192618 interaction type N/A ACSN
FKBP8 BCL2 10409669 20139069 26192618 interaction type N/A ACSN
BCL2 COX5A 10198631 10677502 11323415 11546872 11704864 14747474 15486085 15724238 17244528 17446862 19834492 22039431 23064052 23377657 23430059 23850759 26192618 8929532 9115213 9130713 9430630 9738012 interaction type N/A ACSN
PRKCA BCL2 10677502 10679481 10871288 11323415 16492141 20027184 26192618 9115213 9738012 interaction type N/A ACSN
CUL3 BCL2 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759 26192618 interaction type N/A ACSN
KEAP1 BCL2 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759 26192618 interaction type N/A ACSN
RBX1 BCL2 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759 26192618 interaction type N/A ACSN
BCL2 TRAF2 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 interaction type N/A ACSN
BCL2 MCL1 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 interaction type N/A ACSN
BCL2 GRB2 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 17446862 19289794 19565474 22039431 23064052 23377657 23430059 23850759 24027568 26192618 8929532 9069260 9872359 interaction type N/A ACSN
BCL2 RAF1 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 15849194 17446862 19289794 19565474 22039431 23064052 23180781 23377657 23430059 23850759 24027568 26192618 8929532 9069260 9872359 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
CREB1 BCL2 19815709 26192618 interaction type N/A ACSN
GLI1 BCL2 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257 26192618 interaction type N/A ACSN
BCL2 TFAP2A 12391156 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
BCL2 RB1 12391156 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 FKBP8 12510191 15733859 17942410 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
BCL2 MAPK8 15733859 23180781 phosphorylation reaction in-gel kinase assay InnateDB
BAX BCL2 17525161 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK1 BCL2 15225643 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
BCL2 PTPA 15225643 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 CEBPB 19487031 19717648 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 LGALS3 23180781 8692888 physical association anti tag coimmunoprecipitation InnateDB
BIK BCL2 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 STAT3 15805299 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 GLI2 15520176 21483830 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
BCL2 GLI1 21483830 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 LEF1 21795403 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2 MYB 21795403 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF4 BCL2 23180781 25644173 physical association anti tag coimmunoprecipitation InnateDB
BCL2 BCL2 12624108 26467481 8183370 interaction type,bind,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR BCL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ATF1 BCL2 10542244 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CREB1 BCL2 10542244 17290286 19626458 8816467 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
E2F1 BCL2 11559537 12679318 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ESR1 BCL2 10542244 11261829 18414489 19148464 9306964 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 BCL2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 BCL2 18971253 19127412 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
MYC BCL2 12695333 18809243 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PGR BCL2 17785366 9306964 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
PPARG BCL2 14960510 15067355 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP1 BCL2 10542244 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TFAP2A BCL2 12391156 16533807 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 BCL2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BCL2 12970736 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR BCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ABL1 BCL2 11753601 trascriptional regulation,stimulation inferred by curator TFlink
ATF5 BCL2 21212266 trascriptional regulation,stimulation inferred by curator TFlink
ATM BCL2 16214353 trascriptional regulation,stimulation inferred by curator TFlink
BACH2 BCL2 18929412 trascriptional regulation,stimulation inferred by curator TFlink
DDB2 BCL2 20013802 trascriptional regulation,stimulation inferred by curator TFlink
DEK BCL2 17685435 trascriptional regulation,stimulation inferred by curator TFlink
ERCC2 BCL2 22387547 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 BCL2 14555646 15520176 19074837 21135115 24739390 trascriptional regulation,stimulation inferred by curator TFlink
GLI2 BCL2 16880536 21135115 trascriptional regulation,stimulation inferred by curator TFlink
HOXA1 BCL2 12482855 15665309 trascriptional regulation,stimulation inferred by curator TFlink
ING2 BCL2 15748897 trascriptional regulation,stimulation inferred by curator TFlink
ING4 BCL2 19895734 20707719 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 BCL2 10918594 trascriptional regulation,stimulation inferred by curator TFlink
MSX2 BCL2 21730974 trascriptional regulation,stimulation inferred by curator TFlink
MYB BCL2 11675351 16088151 20659323 trascriptional regulation,stimulation inferred by curator TFlink
NCOA3 BCL2 22213475 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BCL2 12032828 14739605 14978135 15120608 16022909 16453001 17673602 18031796 18158998 18566231 18761399 19233129 19259124 20103608 20332461 20446017 21503108 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 BCL2 16085054 trascriptional regulation,stimulation inferred by curator TFlink
PARP1 BCL2 20564216 trascriptional regulation,stimulation inferred by curator TFlink
PAWR BCL2 11912153 9989812 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 BCL2 22105368 trascriptional regulation,stimulation inferred by curator TFlink
PER1 BCL2 19675098 trascriptional regulation,stimulation inferred by curator TFlink
RELA BCL2 14739605 14978135 15120608 16022909 16453001 17673602 18031796 18158998 18566231 18761399 19233129 19259124 20103608 20332461 20446017 21503108 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 BCL2 20564216 21310710 trascriptional regulation,stimulation inferred by curator TFlink
SIM2 BCL2 21729534 trascriptional regulation,stimulation inferred by curator TFlink
SMAD2 BCL2 24739390 trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 BCL2 24739390 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 BCL2 10542244 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 BCL2 15184887 15805299 18320073 18839277 19926637 20043094 20446017 21172343 21344490 21385902 21435102 22313388 22504301 trascriptional regulation,stimulation inferred by curator TFlink
TBP BCL2 11313951 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 BCL2 23671559 trascriptional regulation,stimulation inferred by curator TFlink
TCF4 BCL2 23671559 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BCL2 11313951 17693666 19411072 20428827 21859835 9000137 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 BCL2 23095743 trascriptional regulation,stimulation inferred by curator TFlink
WT1 BCL2 12644474 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB16 BCL2 14769944 trascriptional regulation,stimulation inferred by curator TFlink
POLR1H BCL2 16373708 16609701 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYBL1 BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB2 BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A BCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000031E12 BCL2 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000A07C1 BCL2 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000204177 BCL2 22967897 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000008A99 BCL2 19843160 23276710 rna interference,inhibition western blot miRSponge
URS00003BBF48 BCL2 21455217 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000171CD1 BCL2 16166262 17707831 18362358 19478946 19903841 20876285 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000041CB9C BCL2 N/A 18449891 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002075FA BCL2 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000018C928 BCL2 20162574 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000236310 BCL2 20162574 22207524 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00001CC379 BCL2 22848417 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 BCL2 19074876 rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000040EE1D BCL2 20727858 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000012A1DD BCL2 21993663 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 BCL2 21993663 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 BCL2 19074899 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F BCL2 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000009262D BCL2 17072344 20048743 21468550 22528454 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000076995 BCL2 20041405 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D BCL2 20041405 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 BCL2 17656095 17914404 18505919 18803879 19461653 19683563 20598588 21399894 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000027352D BCL2 18803879 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002C7B2B BCL2 18803879 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000031B6ED BCL2 21640710 22072615 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000055BBE5 BCL2 21993663 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001F5B39 BCL2 21569010 rna interference,inhibition chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay miRSponge
URS00002E857A BCL2 20816946 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS0000008A99 BCL2 19843160 20878132 22160209 22743998 23276710 25416803 25492481 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00003BBF48 BCL2 21455217 22743998 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000171CD1 BCL2 16166262 17260024 17707831 18362358 18927107 19478946 19903841 20876285 22473208 22743998 25416803 26397135 27596960 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS000040EE1D BCL2 20727858 22328513 22473208 22743998 23451060 25416803 26064276 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000029D9F1 BCL2 18927107 19070389 19074899 22743998 22892391 23152059 24960059 25416803 27519795 28280358 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS000009262D BCL2 17072344 17478730 18927107 20048743 21376256 21468550 22528454 22710123 22743998 24606718 25327529 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS00000ED600 BCL2 20584986 22328513 22743998 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr miRDeathDB,TarBase
URS0000031E12 BCL2 17260024 18927107 mrna cleavage,inhibition N/A miR2Disease
URS00000A07C1 BCL2 17260024 18927107 mrna cleavage,inhibition N/A miR2Disease
URS000041CB9C BCL2 18449891 18927107 19232449 22473208 23907579 25416803 26884837 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000EED18 BCL2 17540599 17656095 17914404 18505919 18803879 18927107 19461653 19683563 20598588 21399894 21566225 23292172 23862748 24565525 25416803 25910896 26406332 26802970 27939626 28340489 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000027352D BCL2 17656095 18803879 18927107 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00002C7B2B BCL2 17656095 18803879 18927107 24960059 25416803 26795575 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000042E1F BCL2 19666108 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002075FA BCL2 19666108 24280866 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272A3D BCL2 20041405 23894561 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000076995 BCL2 20041405 25006537 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000236310 BCL2 20162574 22207524 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000018C928 BCL2 20162574 25416803 25898913 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001270D3 BCL2 18803879 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00000B59A2 BCL2 19074876 25416803 26550150 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E857A BCL2 20816946 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000031B6ED BCL2 21640710 22072615 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001F5B39 BCL2 21569010 24248414 24260067 24960059 25416803 27351886 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000012A1DD BCL2 21993663 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 BCL2 21993663 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000055BBE5 BCL2 21993663 25416803 26513239 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000204177 BCL2 22967897 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000FFC8B BCL2 21463514 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001CC379 BCL2 22848417 23936432 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000052E1A6 BCL2 23293219 25416803 mrna cleavage,inhibition immunocytochemistry TarBase
URS00000F31F4 BCL2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C BCL2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000016914 BCL2 23612742 24297308 25416803 26397843 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 BCL2 23603512 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000035CC3E BCL2 24280866 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007D64A BCL2 21258880 25416803 26339338 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000034B6F5 BCL2 24855559 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase
URS00001F0C23 BCL2 25416803 26297542 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000019D79B BCL2 23754151 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS000032015F BCL2 24157866 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002152A8 BCL2 24178239 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000184017 BCL2 22989374 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS00000F6E49 BCL2 23856992 24931256 25416803 28343379 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000535FDD BCL2 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000044FD7 BCL2 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000023BE29 BCL2 25416803 27244080 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C0D3F BCL2 25416803 27517917 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00004959F4 BCL2 25416803 27627897 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001B9F58 BCL2 25416803 27965982 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS00000FFE5F BCL2 25416803 28044223 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00004BCD9C BCL2 25416803 27596960 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000122ED0 BCL2 25416803 27422937 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 BCL2 22135298 phosphorylation N/A PhosphoSite
CDK1 BCL2 22135298 phosphorylation N/A PhosphoSite
MAPK14 BCL2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 BCL2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCA BCL2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK8 BCL2 22135298 phosphorylation N/A PhosphoSite
HRAS BCL2 25361965 interaction type N/A PTMCode2
BCL2 HRAS 25361965 interaction type N/A PTMCode2
AVEN BCL2 25361965 interaction type N/A PTMCode2
BCL2 AVEN 25361965 interaction type N/A PTMCode2
FKBP8 BCL2 25361965 interaction type N/A PTMCode2
BCL2 FKBP8 25361965 interaction type N/A PTMCode2
CPT1A BCL2 25361965 interaction type N/A PTMCode2
BCL2 CPT1A 25361965 interaction type N/A PTMCode2
BCL2L1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BCL2L1 25361965 interaction type N/A PTMCode2
RAF1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 RAF1 25361965 interaction type N/A PTMCode2
PIN1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 PIN1 25361965 interaction type N/A PTMCode2
BCL2 MAPK1 25361965 interaction type N/A PTMCode2
CASP2 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CASP2 25361965 interaction type N/A PTMCode2
CYCS BCL2 25361965 interaction type N/A PTMCode2
BCL2 CYCS 25361965 interaction type N/A PTMCode2
PPP3R1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 PPP3R1 25361965 interaction type N/A PTMCode2
MOAP1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 MOAP1 25361965 interaction type N/A PTMCode2
SPNS1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 SPNS1 25361965 interaction type N/A PTMCode2
PKMYT1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 PKMYT1 25361965 interaction type N/A PTMCode2
BAD BCL2 25361965 interaction type N/A PTMCode2
BCL2 BAD 25361965 interaction type N/A PTMCode2
RAD9A BCL2 25361965 interaction type N/A PTMCode2
BCL2 RAD9A 25361965 interaction type N/A PTMCode2
BIK BCL2 25361965 interaction type N/A PTMCode2
BCL2 BIK 25361965 interaction type N/A PTMCode2
TP53 BCL2 25361965 interaction type N/A PTMCode2
BCL2 TP53 25361965 interaction type N/A PTMCode2
CASP3 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CASP3 25361965 interaction type N/A PTMCode2
NR3C1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 NR3C1 25361965 interaction type N/A PTMCode2
BCL2 MAPK11 25361965 interaction type N/A PTMCode2
MAPK11 BCL2 25361965 interaction type N/A PTMCode2
BCL2 TP53BP2 25361965 interaction type N/A PTMCode2
TP53BP2 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BMF 25361965 interaction type N/A PTMCode2
BMF BCL2 25361965 interaction type N/A PTMCode2
BCL2 BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L11 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BCL2 25361965 interaction type N/A PTMCode2
BCL2 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BECN1 25361965 interaction type N/A PTMCode2
BECN1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BNIP3 25361965 interaction type N/A PTMCode2
BNIP3 BCL2 25361965 interaction type N/A PTMCode2
BCL2 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BAG3 25361965 interaction type N/A PTMCode2
BAG3 BCL2 25361965 interaction type N/A PTMCode2
BCL2 HSPA1A 25361965 interaction type N/A PTMCode2
HSPA1A BCL2 25361965 interaction type N/A PTMCode2
BCL2 MYC 25361965 interaction type N/A PTMCode2
MYC BCL2 25361965 interaction type N/A PTMCode2
BCL2 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BCL2 25361965 interaction type N/A PTMCode2
BCL2 PPP3CA 25361965 interaction type N/A PTMCode2
PPP3CA BCL2 25361965 interaction type N/A PTMCode2
BCL2 PPP2CA 25361965 interaction type N/A PTMCode2
PPP2CA BCL2 25361965 interaction type N/A PTMCode2
SOD1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 SOD1 25361965 interaction type N/A PTMCode2
RRAS BCL2 25361965 interaction type N/A PTMCode2
BCL2 RRAS 25361965 interaction type N/A PTMCode2
CDK2 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CDK2 25361965 interaction type N/A PTMCode2
BCL2L10 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BCL2L10 25361965 interaction type N/A PTMCode2
PPP1CA BCL2 25361965 interaction type N/A PTMCode2
BCL2 PPP1CA 25361965 interaction type N/A PTMCode2
BNIP2 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BNIP2 25361965 interaction type N/A PTMCode2
BAX BCL2 25361965 interaction type N/A PTMCode2
BCL2 BAX 25361965 interaction type N/A PTMCode2
BCL2 MAPK14 25361965 interaction type N/A PTMCode2
SIVA1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 SIVA1 25361965 interaction type N/A PTMCode2
BCL2 PRKCA 25361965 interaction type N/A PTMCode2
BAG4 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BAG4 25361965 interaction type N/A PTMCode2
BAG1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BAG1 25361965 interaction type N/A PTMCode2
PML BCL2 25361965 interaction type N/A PTMCode2
BCL2 PML 25361965 interaction type N/A PTMCode2
PMAIP1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 PMAIP1 25361965 interaction type N/A PTMCode2
BCL2L14 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BCL2L14 25361965 interaction type N/A PTMCode2
BID BCL2 25361965 interaction type N/A PTMCode2
BCL2 BID 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 BCL2 11988841 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBE2I BCL2 25348397 N/A physical interaction ComPPI
DYNLL1 BCL2 25348397 N/A physical interaction ComPPI
BCL2L11 BCL2 10198631 14525934 15694340 16697956 17074758 17289999 21199865 23845444 24234451 25348397 26004684 9430630 9463381 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
PPP1CC BCL2 25348397 N/A physical interaction,antibody array ComPPI
BAG3 BCL2 11513873 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
KRAS BCL2 10490827 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CRYAB BCL2 25348397 N/A physical interaction ComPPI
PPP1CB BCL2 17274640 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
XIAP BCL2 25348397 N/A physical interaction ComPPI
BIK BCL2 12853473 14525934 16697956 17289999 24234451 25348397 9463381 9525867 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
TP53BP2 BCL2 14525934 18719108 24234451 25348397 8668206 N/A affinity chromatography technology,two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescence technology,peptide array,surface plasmon resonance,physical interaction,biochemical,enzyme linked immunosorbent assay,in vitro,proximity ligation assay,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
KEAP1 BCL2 25348397 N/A physical interaction ComPPI
SMN1 BCL2 14525934 25348397 9389483 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CYCS BCL2 10622714 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2L1 BCL2 11583631 14525934 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,HPRD
BAD BCL2 11483855 14525934 15694340 16697956 17446862 19168699 24234451 25348397 7834748 9388232 9463381 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MOAP1 BCL2 11060313 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK1 BCL2 10567572 12039864 14525934 15225643 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HRAS BCL2 10490827 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8 BCL2 10567572 12039864 14525934 15225643 15733859 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKCA BCL2 14525934 25348397 9738012 N/A experimental interaction detection,in vivo ComPPI,HPRD
RRAS BCL2 14525934 25348397 27898060 8232588 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
CASP3 BCL2 11948397 14525934 25348397 9395403 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK3 BCL2 10677502 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HIF1A BCL2 25348397 N/A physical interaction ComPPI
MAPK14 BCL2 11495898 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BLK BCL2 14525934 25348397 9525867 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKACA BCL2 11158204 14525934 25348397 7929424 9115213 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPARA BCL2 25348397 26556865 27898060 N/A physical interaction ComPPI,OmniPath
IRS2 BCL2 25348397 N/A physical interaction ComPPI
HSP90AA1 BCL2 25348397 N/A physical interaction ComPPI
BAG1 BCL2 25348397 N/A two hybrid,physical interaction,physical interaction,in vitro ComPPI
PARP1 BCL2 11790116 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP2R5A BCL2 11929874 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CALR BCL2 21139567 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
HSPA1A BCL2 10354271 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
HSPA1B BCL2 25348397 N/A physical interaction,in vivo ComPPI
RAD9A BCL2 10620799 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MCL1 BCL2 21139567 24234451 25348397 27898060 7937747 colocalization two hybrid,cosedimentation through density gradient,physical interaction ComPPI,IntAct,OmniPath
CASP8 BCL2 11406564 14525934 16183855 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
IKBKB BCL2 25348397 N/A physical interaction ComPPI
PPP1CA BCL2 11390485 14525934 17274640 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,antibody array,two hybrid ComPPI,HPRD,IntAct,OmniPath
MYC BCL2 14525934 15210690 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PXN BCL2 10417825 25348397 27898060 N/A in vitro ComPPI,OmniPath
SERPINB8 BCL2 25348397 N/A physical interaction ComPPI
VDAC1 BCL2 19706527 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2CA BCL2 14525934 15225643 24234451 25348397 9852076 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SQSTM1 BCL2 25348397 N/A physical interaction ComPPI
MDM4 BCL2 19521340 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 BCL2 14525934 15619620 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCAP31 BCL2 14525934 24234451 25348397 9334338 physical association coimmunoprecipitation,experimental interaction detection,far western blotting,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SIVA1 BCL2 14739602 24234451 25348397 physical association pull down ComPPI,IntAct
IRS1 BCL2 25348397 N/A physical interaction ComPPI
NR4A1 BCL2 14525934 14980220 18835031 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,circular dichroism,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RAF1 BCL2 14525934 25348397 8910675 8929532 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RTN4 BCL2 11126360 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CHUK BCL2 25348397 N/A physical interaction ComPPI
HSPA9 BCL2 21139567 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
BAG4 BCL2 11527400 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SF1 BCL2 14525934 25348397 8668206 N/A experimental interaction detection,in vitro ComPPI,HPRD
BAK1 BCL2 11206074 11728179 14525934 24234451 25348397 26004684 9463381 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2 ATP2A2 14525934 25348397 27898060 9788433 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
BCL2 PPP3CA 14525934 19706527 25348397 27898060 7593193 9109491 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
BCL2 TMBIM6 14525934 25348397 9660918 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2 CPT1A 14525934 25348397 27898060 9070836 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
BCL2 NLRP1 14525934 17418785 19223583 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,confocal microscopy ComPPI,HPRD,IntAct
BCL2 NMT2 14525934 16530191 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BCL2 PML 14525934 15231068 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2 ITPR1 14525934 15613488 19706527 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
BCL2 SOD1 14525934 15233914 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BCL2 PSEN1 10521466 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
BCL2 NRAS 10490827 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2 BAX 14525934 15231068 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 24234451 25348397 26004684 8358790 9111042 9388232 9463381 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence technology,physical interaction,enzyme linked immunosorbent assay,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2 TOMM20 14525934 25348397 9119086 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2 PKMYT1 11326318 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2 MAPK11 25348397 N/A in vitro ComPPI
BCL2 BNIP1 10217402 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
BCL2 BNIP2 10381623 12901880 14525934 24234451 25348397 7954800 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
BCL2 BNIP3 10381623 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
BCL2 HRK 10075695 14525934 25348397 9130713 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BCL2 ITM2B 12082633 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2 BECN1 14525934 17446862 19050071 19180116 19959994 21139567 21358617 23541952 23954414 24034250 24234451 24472739 25348397 29849149 9765397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2 FKBP8 12510191 14525934 15733859 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2 BCL2L14 11054413 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2 BMF 11546872 14525934 16697956 17289999 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BCL2 BCL2L10 11278245 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2 TP53AIP1 25348397 N/A physical interaction,in vivo ComPPI
BCL2 SPNS1 12815463 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
BCL2 PMAIP1 10807576 14525934 21454712 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BCL2 BBC3 15694340 16697956 17289999 24234451 25348397 26431330 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct
BCL2 BCLAF1 10330179 14525934 23541952 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
BCL2 BFAR 10716992 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2 BNIPL 12901880 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
BCL2 BID 11583631 12624108 14525934 16697956 17289999 19074266 24234451 25348397 9463381 9727491 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction ComPPI,HPRD,IntAct
BCL2 BBC3 11463392 14525934 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL2 CAPN2 25348397 N/A physical interaction ComPPI
BCL2 CDK1 25348397 N/A physical interaction ComPPI
BCL2 AVEN 25348397 N/A physical interaction ComPPI
BCL2 BNIP3L 10467396 14525934 24234451 25348397 9973195 N/A experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
BCL2 BLID 25348397 N/A physical interaction ComPPI
BCL2 PRKN 25348397 N/A physical interaction ComPPI
BCL2 TP53 12667443 14525934 19521340 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
BCL2 HSP90AA2P 25348397 N/A physical interaction ComPPI
BCL2 CISD2 25348397 N/A physical interaction ComPPI
BCL2 MEX3D 25348397 N/A physical interaction ComPPI
BCL2 HNRNPD 25348397 N/A physical interaction ComPPI
BCL2 ATG12 25348397 N/A physical interaction ComPPI
BCL2 BRCA1 21444675 24234451 25348397 27898060 colocalization,physical association physical interaction,confocal microscopy,proximity ligation assay ComPPI,IntAct,OmniPath
BCL2 AMBRA1 21358617 24234451 25348397 covalent binding,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,fluorescent resonance energy transfer,physical interaction,fluorescence microscopy ComPPI,IntAct
BCL2 IKBKG 25348397 N/A physical interaction ComPPI
BCL2 PPP3CC 25348397 N/A physical interaction ComPPI
BCL2 ATP2A3 25348397 N/A physical interaction ComPPI
BCL2 GIMAP5 25348397 N/A physical interaction ComPPI
BCL2 MAT2A 25348397 N/A physical interaction ComPPI
BCL2 BARD1 25348397 N/A physical interaction ComPPI
BCL2 RTN3 25348397 N/A physical interaction ComPPI
BCL2 SEPTIN4 25348397 N/A physical interaction ComPPI
BCL2 VRK2 16963744 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
BCL2 NAF1 20010695 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
BCL2 PPIF 19228691 24234451 25348397 physical association two hybrid ComPPI,IntAct
BCL2 BECN2 23954414 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BCL2 LRRK2 25348397 N/A protein kinase assay ComPPI
BCL2 RTL10 23055042 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP3R1 BCL2 15757646 24234451 25348397 colocalization pull down,fluorescence microscopy ComPPI,IntAct
PPID BCL2 25348397 N/A physical interaction ComPPI
BCL2 BCL2 14525934 15302859 18835031 24234451 9111042 9463381 physical association anti tag coimmunoprecipitation,experimental interaction detection,two hybrid HPRD,IntAct
BRD2 BCL2 23791182 24234451 association chromatin immunoprecipitation assay IntAct
BCL2 BRD4 23791182 24234451 association chromatin immunoprecipitation assay IntAct
RELA BCL2 18191642 24234451 association chromatin immunoprecipitation assay IntAct
BCL2 IER3 18191642 24234451 association chromatin immunoprecipitation assay IntAct
BCL2 CEBPA 23814099 24234451 association chromatin immunoprecipitation assay IntAct
BCL2 LGALS3 27898060 8692888 N/A N/A OmniPath
SRC BCL2 10567572 12039864 27898060 N/A N/A OmniPath
PRKCA BCL2 27898060 9738012 inhibition,stimulant N/A OmniPath
CREB1 BCL2 10753867 27898060 stimulant N/A OmniPath
FLI1 BCL2 11847117 27898060 stimulant N/A OmniPath
CASP3 BCL2 11948397 27898060 9395403 inhibition N/A OmniPath
BCL2 BID 11583631 12624108 15520201 15694340 16697956 17289999 18835031 19074266 27898060 8918887 9463381 9727491 inhibition N/A OmniPath
BMF BCL2 11546872 16697956 17289999 27898060 inhibition N/A OmniPath
BNIP3 BCL2 10381623 10625696 19136941 23504944 27898060 7954800 inhibition N/A OmniPath
CAPN1 BCL2 12000759 27898060 inhibition N/A OmniPath
BCL2 BAD 11483855 15694340 15849194 15990872 16697956 17446862 19168699 20603619 27898060 7834748 9305851 9388232 9463381 inhibition N/A OmniPath
BAD BCL2 11483855 11583631 15694340 15849194 15990872 16697956 17446862 19168699 20603619 27898060 7834748 9305851 9388232 9463381 inhibition,stimulant N/A OmniPath
BAG1 BCL2 27898060 7834747 8947043 9305631 stimulant N/A OmniPath
BCL2 BAK1 11206074 11728179 14980220 17289999 26004684 27898060 9463381 inhibition N/A OmniPath
JUNB BCL2 11163237 27898060 inhibition N/A OmniPath
CAPN2 BCL2 12000759 27898060 inhibition N/A OmniPath
MAPK3 BCL2 10567572 10669763 10677502 11077443 11495898 12039864 12421819 15703383 16714293 16738310 17097560 18570871 19029119 19336399 25826088 27898060 9312139 9735392 inhibition,stimulant N/A OmniPath
BCL2 CYCS 10622714 12624108 27898060 inhibition N/A OmniPath
TP53 BCL2 11313951 12667443 19007744 19521340 19555669 21597459 21624955 27898060 8205530 inhibition N/A OmniPath
MAPK14 BCL2 11495898 16714293 19336399 27898060 inhibition N/A OmniPath
HSP90AA1 BCL2 18266962 20668552 21543763 27898060 stimulant N/A OmniPath
BBC3 BCL2 15694340 27898060 inhibition N/A OmniPath
PMAIP1 BCL2 10807576 15694340 15725726 21454712 27898060 inhibition N/A OmniPath
BCL2L11 BCL2 10198631 11301022 15136728 15694340 16697956 17074758 17097560 17289999 18498746 19805519 23840878 23845444 26186194 27898060 9430630 9463381 9731710 inhibition N/A OmniPath
DDIT3 BCL2 17652152 27898060 inhibition N/A OmniPath
FUS BCL2 18471544 27898060 inhibition N/A OmniPath
CDK1 BCL2 10766756 11326318 11774038 27898060 9668078 inhibition N/A OmniPath
BCL2 XRCC6 18313378 27898060 inhibition N/A OmniPath
RAF1 BCL2 12488548 15849194 27898060 8910675 8929532 N/A N/A OmniPath
TNF BCL2 10669763 15225643 27898060 N/A N/A OmniPath
NOXA1 BCL2 19879762 27898060 inhibition N/A OmniPath
EIF4G2 BCL2 18450493 27898060 stimulant N/A OmniPath
SPNS1 BCL2 12815463 27898060 inhibition N/A OmniPath
CISD2 BCL2 20010695 27898060 stimulant N/A OmniPath
BCL2 BECN1 16179260 16799551 17438366 17446862 17643073 18281291 18570871 18641390 18772134 19050071 19273585 19347031 19959994 20010695 20622903 20711182 20889974 21358617 21543763 21971985 22622204 23168911 23316280 23479509 23504944 23541952 23564079 23954414 24034250 24472739 25891078 25984893 27898060 9765397 inhibition N/A OmniPath
BCL2 BIK 12853473 15694340 16697956 17289999 22705850 27898060 8816500 9305912 9463381 9488477 9525867 inhibition N/A OmniPath
BAG2 BCL2 27898060 7834747 8692945 stimulant N/A OmniPath
MAPK1 BCL2 10567572 10669763 10677502 10766756 12039864 15225643 27898060 inhibition,stimulant N/A OmniPath
HRK BCL2 10075695 15694340 27898060 9130713 inhibition N/A OmniPath
PPP2CA BCL2 15225643 16717086 27898060 9852076 stimulant N/A OmniPath
BCL2 BAX 10620799 10716992 14980220 15231068 16642033 17097560 17289999 17525161 21199865 21458670 21671007 21778226 22262057 22705850 23479509 26004684 27898060 8183370 8358790 8631771 9111042 9115213 9388232 9463381 9742125 inhibition N/A OmniPath
BCL2 TP53AIP1 12019168 27898060 inhibition N/A OmniPath
DAPK1 BCL2 19395874 27898060 inhibition N/A OmniPath
STAT3 BCL2 11994401 27898060 stimulant N/A OmniPath
FKBP8 BCL2 12510191 15733859 15990872 17379601 17942410 27898060 stimulant N/A OmniPath
PPP2R5C BCL2 27898060 9852076 inhibition N/A OmniPath
BCL2 MAPK8 10567572 12039864 15225643 15733859 27898060 N/A N/A OmniPath
MAPK8 BCL2 10567572 11988841 12039864 15026553 15225643 15733859 15817479 17190831 18471544 18570871 19029119 20388787 21778226 23943652 25619840 27898060 9563469 9738012 inhibition,stimulant N/A OmniPath
PPP1CC BCL2 12051739 27898060 stimulant N/A OmniPath
BBC3 BCL2 11463392 15694340 16697956 17289999 27898060 inhibition N/A OmniPath
BCAP31 BCL2 27898060 9334338 stimulant N/A OmniPath
PPP2R5B BCL2 18845789 27898060 inhibition N/A OmniPath
PPP2CB BCL2 15225643 27898060 9852076 stimulant N/A OmniPath

Visualization










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