GENE：CCL20
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CCL20 |
| FullNmae | C-C motif chemokine ligand 20 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10619 |
| EnsembleID | ENSG00000115009 |
| Uniprot | P78556 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CCL20 | cuproptosis | 36313444 | Finally, seven copper death genes related to lung adenocarcinoma were screened out, including ARHGEF39, EFCC1, SERPIND1, INSL4, ANLN, RHOV and CCL20. | copper death genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CCL20 | GO:0002548,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0006955,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0030593,GO:0031731,GO:0035584,GO:0042742,GO:0043547,GO:0048020,GO:0048247,GO:0060326,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0072678,GO:0072679,GO:2000406 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CCL20 | hsa:6364 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CCL20 | hsa:6364 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
| CCL20 | hsa:6364 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| CCL20 | hsa:6364 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| CCL20 | hsa:6364 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| CCL20 | hsa:6364 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NFKB1 | CCL20 | 11254498 18089854 23180781 | physical association | genetic interference,rna interference,electrophoretic mobility shift assay | InnateDB |
| CTSB | CCL20 | 16709808 23180781 | cleavage reaction,protein cleavage | protease assay | InnateDB |
| CTSD | CCL20 | 16709808 23180781 | cleavage reaction,protein cleavage | protease assay | InnateDB |
| VCAN | CCL20 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| CCL20 | CCR6 | 23180781 9169459 | physical association | saturation binding | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CCL20 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| HIF1A | CCL20 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | CCL20 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | CCL20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CCL20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CCL20 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPD | CCL20 | 23028973 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CCL20 | 19939449 22240809 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CCL20 | 11749970 22240809 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CCL20 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | CCL20 | 22001440 | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS000009262D | CCL20 | 22001440 23817679 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | CCL20 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RALBP1 | CCL20 | 17703191 18239685 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TRAF6 | CCL20 | 18239685 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PF4 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CCL5 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| TGFB3 | CCL20 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CXCL11 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding | ComPPI,IntAct |
| XCL2 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding | ComPPI,IntAct |
| CCL20 | CCR6 | 14525934 25348397 9169459 9223454 9294137 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CCL20 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CCL20 | CXCL17 | 24234451 25348397 28381538 | N/A | filter binding | ComPPI,IntAct |
| CXCL5 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding | ComPPI,IntAct |
| CTSD | CCL20 | 16709808 27898060 | N/A | N/A | OmniPath |
| CTSB | CCL20 | 16709808 27898060 | N/A | N/A | OmniPath |
| CCL20 | CXCR3 | 27898060 9660793 | stimulant | N/A | OmniPath |
| VCAN | CCL20 | 11083865 27898060 | N/A | N/A | OmniPath |
| CCL20 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| CCR6 | CCL20 | 10488147 10498628 27898060 9169459 9223454 9294137 | N/A | N/A | OmniPath |
| CCL20 | CCR6 | 10488147 10498628 12081481 12964882 24218476 27898060 9169459 9223454 9294137 | stimulant | N/A | OmniPath |