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GENE：CCL5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCL5
FullNmae C-C motif chemokine ligand 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10632
EnsembleID ENSG00000271503
Uniprot P13501

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCL5 cuproptosis 36341328 Further, differentially expressed genes with prognostic significance were used to construct a cuproptosis-related gene signature (PGK1, SLC52A2, SEC14L2, RAD23B, SLC16A6, CCL5, and MAL2) and scoring system. cuproptosis-related gene signature

Go Annotation:

GeneSymbol Go id
CCL5 GO:0002407,GO:0002548,GO:0002548,GO:0002676,GO:0004435,GO:0004672,GO:0005515,GO:0005576,GO:0005615,GO:0006816,GO:0006874,GO:0006887,GO:0006935,GO:0006954,GO:0007159,GO:0007186,GO:0007186,GO:0007267,GO:0008009,GO:0008009,GO:0008009,GO:0009615,GO:0009636,GO:0010536,GO:0010759,GO:0010820,GO:0010820,GO:0014911,GO:0016004,GO:0030298,GO:0030335,GO:0030593,GO:0031328,GO:0031584,GO:0031726,GO:0031726,GO:0031726,GO:0031729,GO:0031730,GO:0033634,GO:0034112,GO:0042056,GO:0042102,GO:0042119,GO:0042327,GO:0042379,GO:0042531,GO:0042802,GO:0042803,GO:0043547,GO:0043621,GO:0043922,GO:0044344,GO:0045070,GO:0045071,GO:0045089,GO:0045744,GO:0045785,GO:0045948,GO:0046427,GO:0046817,GO:0048020,GO:0048245,GO:0048246,GO:0048247,GO:0048661,GO:0050796,GO:0050863,GO:0050918,GO:0051897,GO:0051928,GO:0070098,GO:0070098,GO:0070098,GO:0070100,GO:0070233,GO:0070234,GO:0070374,GO:0071346,GO:0071346,GO:0071347,GO:0071347,GO:0071356,GO:0071356,GO:0090026,GO:0098586,GO:2000406,GO:2000503

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCL5 hsa:6352 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CCL5 hsa:6352 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05020 Prion disease - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05131 Shigellosis - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05142 Chagas disease - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05164 Influenza A - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
CCL5 hsa:6352 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TGFBR1 CCL5 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
TGFBR2 CCL5 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
IRF3 CCL5 12388374 17652396 23180781 9891032 physical association affinity chromatography technology,electrophoretic mobility shift assay InnateDB
RELA CCL5 12820969 16931600 22030901 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB CCL5 12820969 23180781 physical association anti tag coimmunoprecipitation InnateDB
REL CCL5 12820969 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIGR CCL5 11509627 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL5 CCR5 10477718 23180781 physical association competition binding InnateDB
CCL5 CCR1 23180781 7545673 8530354 9115216 physical association competition binding InnateDB
ACKR1 CCL5 23180781 7592830 8132497 9195930 physical association competition binding InnateDB
CCL5 VCAN 11083865 23180781 physical association solid phase assay InnateDB
CCL5 PIK3R1 11350939 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL5 CCR3 23180781 8642344 physical association competition binding InnateDB
CCL5 ACKR2 23180781 9405404 physical association competition binding InnateDB
CEBPB CCL5 12388374 23180781 physical association electrophoretic mobility supershift assay InnateDB
CREB1 CCL5 12388374 23180781 physical association electrophoretic mobility supershift assay InnateDB
ATF2 CCL5 12388374 23180781 physical association electrophoretic mobility supershift assay InnateDB
CCL5 IRF1 12388374 23180781 physical association affinity chromatography technology,electrophoretic mobility supershift assay InnateDB
CCL5 IRF7 10938111 23180781 physical association electrophoretic mobility shift assay InnateDB
POLR2F CCL5 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
CCR5 CCL5 12213786 23180781 physical association competition binding InnateDB

Source Target Pmid Interactiontype Methods Database
ATF3 CCL5 10760799 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
JUND CCL5 10760799 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CREB1 CCL5 11413310 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 CCL5 10385645 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 CCL5 10385645 20483755 trascriptional regulation,stimulation inferred by curator TFlink
IRF7 CCL5 10385645 trascriptional regulation,stimulation inferred by curator TFlink
JUN CCL5 11413310 trascriptional regulation,stimulation inferred by curator TFlink
KLF13 CCL5 17513757 22797700 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CCL5 11259372 11389171 11413310 11478739 12122011 19786024 9120310 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA CCL5 15228586 trascriptional regulation,stimulation inferred by curator TFlink
REL CCL5 11259372 trascriptional regulation,stimulation inferred by curator TFlink
RELA CCL5 11259372 11389171 11413310 11478739 12122011 19786024 9120310 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CCL5 11259372 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CCL5 11259372 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CCL5 10760799 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPB CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPD CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink
FOS CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink
FOSB CCL5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 CCL5 20589685 25416803 26126865 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 CCL5 20589685 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000160683 CCL5 23171795 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 CCL5 24996260 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000075AB14 CCL5 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 CCL5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 CCL5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D CCL5 25416803 26126865 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SDC1 CCL5 25361965 interaction type N/A PTMCode2
CCL5 SDC1 25361965 interaction type N/A PTMCode2
CCL5 PF4 25361965 interaction type N/A PTMCode2
PF4 CCL5 25361965 interaction type N/A PTMCode2
CCL5 CCR1 25361965 interaction type N/A PTMCode2
CCR1 CCL5 25361965 interaction type N/A PTMCode2
CCL5 CCR4 25361965 interaction type N/A PTMCode2
CCR4 CCL5 25361965 interaction type N/A PTMCode2
CCL5 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CCL5 25361965 interaction type N/A PTMCode2
CCL5 SDC4 25361965 interaction type N/A PTMCode2
SDC4 CCL5 25361965 interaction type N/A PTMCode2
CCL5 CXCR3 25361965 interaction type N/A PTMCode2
CXCR3 CCL5 25361965 interaction type N/A PTMCode2
CCL2 CCL5 25361965 interaction type N/A PTMCode2
CCL5 CCL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRAS CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CXCL9 CCL5 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
TGFB1 CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
S100A13 CCL5 25348397 N/A physical interaction ComPPI
GRB2 CCL5 14525934 25348397 9009162 N/A experimental interaction detection,in vivo ComPPI,HPRD
FZR1 CCL5 25348397 N/A physical interaction ComPPI
WT1 CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APC CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDH1 CCL5 24234451 25348397 25640309 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN1 CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PF4 CCL5 14525934 15459010 24234451 25348397 28381538 N/A experimental interaction detection,filter binding,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
CXCR3 CCL5 25348397 N/A physical interaction,biochemical ComPPI
PIGR CCL5 11509627 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CCL5 SDC1 14525934 14637022 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CCL5 DPP4 11390394 14525934 21314817 24234451 25348397 27898060 9516414 cleavage reaction experimental interaction detection,protease assay,in vitro ComPPI,HPRD,IntAct,OmniPath
CCL5 CCR1 11116158 12270118 14525934 14637022 24234451 25348397 28381538 7545673 9289016 association,physical association experimental interaction detection,fluorescence-activated cell sorting,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
CCL5 CCR5 10477718 11116158 14525934 14637022 23480650 24234451 25348397 28381538 8663314 9289016 association,physical association experimental interaction detection,fluorescence-activated cell sorting,nuclear magnetic resonance,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
CCL5 IGFBP7 12847218 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CCL5 CCR4 12270118 14525934 25348397 8573157 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CCL5 ACKR4 14525934 25348397 27898060 9405404 9469451 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CCL5 SDC4 14525934 14637022 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CCL5 ACKR2 14525934 25348397 9405404 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CCL5 CXCL8 25348397 N/A physical interaction ComPPI
CCL5 CCR3 14525934 25348397 8642344 9289016 N/A experimental interaction detection,physical interaction,biochemical ComPPI,HPRD
CCL5 VCAN 11083865 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCL5 TRIP6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCL5 SLC2A5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 RANGAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCL5 RELA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 EDC4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCL5 BAG4 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 BCAR3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 PALB2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 PHB 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCL5 C4A 25348397 N/A physical interaction ComPPI
CCL5 NTMT1 25348397 N/A physical interaction ComPPI
CCL5 SPATA20 25348397 N/A physical interaction ComPPI
CCL5 AK4 25348397 N/A physical interaction ComPPI
CCL5 SPRYD4 25348397 N/A physical interaction ComPPI
CCL5 GPD1L 25348397 N/A physical interaction ComPPI
CCL5 CXCR5 25348397 N/A physical interaction,biochemical ComPPI
CCL5 TNFAIP6 24234451 24501198 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL17 24234451 25348397 28381538 physical association filter binding,surface plasmon resonance,proximity ligation assay,surface plasmon resonance array,solution state nmr ComPPI,IntAct
CCL5 CXCL12 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 PPBP 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CXCL6 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CXCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 XCL1 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL28 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL26 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL25 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL24 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL20 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL16 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL13 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL11 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CXCL10 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CXCL17 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL27 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
UBAC1 CCL5 25348397 N/A physical interaction ComPPI
CXCL11 CCL5 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
XCL2 CCL5 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CXCL14 CCL5 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 ACKR1 12081195 14525934 17416748 N/A experimental interaction detection HPRD
CCL5 CCL5 14525934 15530372 21827949 23480650 24234451 28381538 7542919 8576227 9889151 association dynamic light scattering,experimental interaction detection,fluorescence-activated cell sorting,mass spectrometry studies of complexes,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,x ray scattering HPRD,IntAct
CCL5 SNAI1 24234451 25314079 association chromatin immunoprecipitation assay IntAct
IRF3 CCL5 11991981 27898060 stimulant N/A OmniPath
SP1 CCL5 19124744 27898060 stimulant N/A OmniPath
CCL5 CXCR3 27898060 9660793 stimulant N/A OmniPath
CCL5 CCR5 10318947 10477718 10488147 11116158 11449371 12213786 14637022 16298345 23480650 24218476 27898060 8663314 9207005 9289016 9334377 9790730 stimulant N/A OmniPath
CCL5 CCR3 10733106 10734056 11449371 24218476 27898060 7622448 8642344 9289016 stimulant N/A OmniPath
CCL5 CCR4 12270118 24218476 27898060 8573157 stimulant N/A OmniPath
CCL5 CCR1 10734056 10910894 11116158 11449371 12270118 14637022 24218476 27898060 7545673 7622448 8530354 9115216 9289016 9336350 9624164 stimulant N/A OmniPath
CCL5 ACKR2 24218476 27898060 9405404 N/A N/A OmniPath
CCL5 ACKR1 12081195 17416748 24218476 27898060 7592830 8132497 9195930 N/A N/A OmniPath

Visualization










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