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GENE：CCL8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCL8
FullNmae C-C motif chemokine ligand 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10635
EnsembleID ENSG00000108700
Uniprot P80075

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCL8 cuproptosis 38006800 Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. cuproptosis-related genes
CCL8 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study

Go Annotation:

GeneSymbol Go id
CCL8 GO:0002548,GO:0004672,GO:0005515,GO:0005615,GO:0006816,GO:0006874,GO:0006887,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008201,GO:0009615,GO:0016004,GO:0030593,GO:0043547,GO:0044828,GO:0048020,GO:0048245,GO:0048247,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCL8 hsa:6355 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CCL8 hsa:6355 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CCL8 hsa:6355 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CCL2 CCL8 16803905 23180781 physical association mass spectrometry studies of complexes,nuclear magnetic resonance InnateDB
CCL8 CCL8 16803905 23180781 physical association mass spectrometry studies of complexes InnateDB
CCR5 CCL8 10477718 23180781 physical association competition binding InnateDB
VCAN CCL8 11083865 23180781 physical association solid phase assay InnateDB
ACKR2 CCL8 23180781 9405404 physical association competition binding InnateDB
CCR1 CCL8 23180781 9115216 physical association competition binding InnateDB
CCR2 CCL8 23180781 9115216 physical association competition binding InnateDB
CCL8 ACKR4 10734104 23180781 physical association competition binding InnateDB
CCL8 BCL6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL8 STAT6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
MMP12 CCL8 18660381 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 CCL8 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 CCL8 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CCL8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CCL8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC864 CCL8 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CCL8 CCR2 25361965 interaction type N/A PTMCode2
CCR2 CCL8 25361965 interaction type N/A PTMCode2
CCL8 CCR1 25361965 interaction type N/A PTMCode2
CCR1 CCL8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP3 CCL8 12149192 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CCR5 CCL8 10477718 14525934 25348397 9468473 N/A experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
CCR1 CCL8 14525934 25348397 9115216 N/A experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
ACKR2 CCL8 14525934 25348397 9405404 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CCL13 CCL8 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CCR2 25348397 N/A physical interaction,biochemical,in vivo ComPPI
CCL8 ACKR4 10734104 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD
CCL8 VCAN 11083865 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCL8 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CCL26 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CCL11 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CXCL10 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CXCL8 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 PPBP 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CXCL17 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL11 CCL8 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
XCL2 CCL8 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL8 CCR3 14525934 9005985 N/A experimental interaction detection HPRD
ACKR1 CCL8 13679391 14525934 N/A experimental interaction detection HPRD
VCAN CCL8 11083865 27898060 N/A N/A OmniPath
CCL8 VCAN 11083865 27898060 N/A N/A OmniPath
CCL2 CCL8 16803905 27898060 N/A N/A OmniPath
CCR5 CCL8 10477718 27898060 9468473 N/A N/A OmniPath
CCL8 CCR5 10477718 24218476 27898060 9468473 9790730 stimulant N/A OmniPath
CCL8 CCR3 24218476 27898060 9005985 stimulant N/A OmniPath
CCR1 CCL8 27898060 9115216 N/A N/A OmniPath
CCL8 CCR1 24218476 27898060 9115216 stimulant N/A OmniPath
CCR2 CCL8 12149192 27898060 9115216 9195948 N/A N/A OmniPath
CCL8 CCR2 12149192 12554737 24218476 27898060 9115216 9195948 stimulant N/A OmniPath
ACKR2 CCL8 27898060 9405404 N/A N/A OmniPath
CCL8 ACKR2 24218476 27898060 9405404 N/A N/A OmniPath
ACKR4 CCL8 10734104 27898060 9405404 N/A N/A OmniPath

Visualization










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