Gene Information gene info

  1. Home

GENE：CCS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCS
FullNmae copper chaperone for superoxide dismutase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1613
EnsembleID ENSG00000173992
Uniprot O14618

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCS cuproptosis 36882769 Copper chaperone for superoxide dismutase(CCS) directly interacted with and transported copper ions to superoxide dismutase 1(SOD1) . transported copper
CCS cuproptosis 38339398 Copper Chaperone for Superoxide Dismutase (CCS):Forms heterodimers with copper–zinc superoxide dismutase copper ionophores
CCS cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
CCS cuproptosis 38348451 SOD1 is a copper-containing enzyme that clears superoxide radicals within the cell. CCS helps SOD1 in its proper folding and activity by providing copper ions. This is crucial for maintaining the redox balance within the cell and preventing oxidative damage. CRGs in the cuproptosis pathway
CCS cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
CCS cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
CCS cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
CCS cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CCS GO:0005507,GO:0005507,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006801,GO:0015035,GO:0015680,GO:0016532,GO:0019430,GO:0034599,GO:0045296

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCS hsa:9973 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
CCS hsa:9973 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL7R CCS 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 CCS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE CCS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC CCS 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002E0524 CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E CCS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 CCS 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED CCS 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A CCS 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B0E50 CCS 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB14 CCS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 CCS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 CCS 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF CCS 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
YWHAG CCS 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
XIAP CCS 25348397 N/A physical interaction ComPPI
CDH1 CCS 25348397 N/A physical interaction ComPPI
TXN CCS 25348397 N/A physical interaction ComPPI
CUL4B CCS 25348397 N/A physical interaction ComPPI
APBA1 CCS 11115513 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ATOX1 CCS 25348397 N/A physical interaction ComPPI
RAE1 CCS 25348397 N/A physical interaction ComPPI
SOD1 CCS 10677207 12968035 14525934 24234451 25348397 9726962 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CCS SLC31A1 25348397 N/A physical interaction ComPPI
CCS CAPZA2 25348397 N/A physical interaction ComPPI
CCS SCRN2 25348397 N/A physical interaction ComPPI
CCS GMPPB 25348397 N/A physical interaction ComPPI
CCS GOT1 25348397 N/A physical interaction ComPPI
CCS PPIL3 25348397 N/A physical interaction ComPPI
CCS DUSP13 25348397 N/A physical interaction ComPPI
CCS DUSP13 25348397 N/A physical interaction ComPPI
CCS CCS 10677207 14525934 N/A experimental interaction detection HPRD
CCS APBA2 24234451 29578633 N/A fluorescence polarization spectroscopy IntAct
IL7R CCS 20167604 27898060 N/A N/A OmniPath

Visualization










  Return