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GENE：CDC16

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDC16
FullNmae cell division cycle 16
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1720
EnsembleID ENSG00000130177
Uniprot Q13042

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDC16 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC16 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CDC16 GO:0005515,GO:0005654,GO:0005680,GO:0005680,GO:0005680,GO:0005680,GO:0005737,GO:0005737,GO:0005813,GO:0005829,GO:0007049,GO:0007346,GO:0016567,GO:0031145,GO:0031145,GO:0045842,GO:0051301,GO:0051445,GO:0070979,GO:0072686

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDC16 hsa:8881 path:hsa04110 Cell cycle - Homo sapiens (human)
CDC16 hsa:8881 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
CDC16 hsa:8881 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
CDC16 hsa:8881 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
CDC16 hsa:8881 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CDC16 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CDC16 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CDC16 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CDC16 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CDC16 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CDC16 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC CDC16 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 CDC16 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 CDC16 22135298 phosphorylation N/A PhosphoSite
PLK1 CDC16 22135298 phosphorylation N/A PhosphoSite
ANAPC1 CDC16 25361965 interaction type N/A PTMCode2
CDC16 ANAPC1 25361965 interaction type N/A PTMCode2
CDC20 CDC16 25361965 interaction type N/A PTMCode2
CDC16 CDC20 25361965 interaction type N/A PTMCode2
FBXO5 CDC16 25361965 interaction type N/A PTMCode2
CDC16 FBXO5 25361965 interaction type N/A PTMCode2
HDAC3 CDC16 25361965 interaction type N/A PTMCode2
CDC16 HDAC3 25361965 interaction type N/A PTMCode2
CDC16 NEK2 25361965 interaction type N/A PTMCode2
NEK2 CDC16 25361965 interaction type N/A PTMCode2
CDC16 BUB3 25361965 interaction type N/A PTMCode2
BUB3 CDC16 25361965 interaction type N/A PTMCode2
CDC16 CDC23 25361965 interaction type N/A PTMCode2
CDC23 CDC16 25361965 interaction type N/A PTMCode2
CDC16 FZR1 25361965 interaction type N/A PTMCode2
FZR1 CDC16 25361965 interaction type N/A PTMCode2
CCNB1 CDC16 25361965 interaction type N/A PTMCode2
CDC16 CCNB1 25361965 interaction type N/A PTMCode2
ANAPC2 CDC16 25361965 interaction type N/A PTMCode2
CDC16 ANAPC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 CDC16 25348397 N/A physical interaction ComPPI
SNW1 CDC16 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GATAD2B CDC16 25348397 N/A physical interaction ComPPI
CDC5L CDC16 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK9 CDC16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SH3KBP1 CDC16 25348397 N/A physical interaction ComPPI
FTH1 CDC16 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SKIL CDC16 11691834 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TP53BP1 CDC16 25348397 N/A physical interaction ComPPI
B4GALT7 CDC16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IQGAP3 CDC16 25348397 N/A physical interaction ComPPI
ZBTB5 CDC16 25348397 N/A physical interaction ComPPI
DAB2 CDC16 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RB1 CDC16 25348397 N/A physical interaction ComPPI
CREBBP CDC16 25348397 N/A physical interaction ComPPI
SMAD2 CDC16 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EP300 CDC16 25348397 N/A physical interaction ComPPI
SMAD3 CDC16 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDC16 PPP5C 14525934 25348397 9405394 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CDC16 MAD2L1 14525934 20360068 24234451 25348397 9628895 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDC16 BUB1B 10477750 11030144 14525934 20360068 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDC16 CDC20 12196507 14525934 20360068 24234451 25348397 26496610 9628895 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDC16 CDC27 14525934 16648845 20360068 24234451 25348397 26496610 9405394 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,tandem affinity purification,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct
CDC16 ANAPC11 11739784 14525934 20360068 24234451 25348397 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDC16 CDC23 10318877 14525934 20360068 24234451 25348397 26496610 27173435 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
CDC16 ANAPC10 10318877 14525934 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDC16 ANAPC1 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 TTK 25348397 N/A physical interaction ComPPI
CDC16 MDC1 25348397 N/A physical interaction ComPPI
CDC16 ANAPC4 20360068 24234451 25348397 26496610 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 ANAPC7 10318877 14525934 20360068 24234451 25348397 association,physical association experimental interaction detection,physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
CDC16 SMARCAD1 25348397 N/A physical interaction ComPPI
CDC16 CCNB1 25348397 N/A physical interaction ComPPI
CDC16 COPS2 25348397 N/A physical interaction ComPPI
CDC16 FBXO5 20360068 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 ANAPC2 20360068 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 ANAPC5 20360068 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 PAXIP1 25348397 N/A physical interaction ComPPI
CDC16 ANAPC15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 TRIM33 25348397 N/A physical interaction ComPPI
CDC16 DNAJA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC16 HINT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC16 XRCC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC16 C11ORF49 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC16 PHF8 25348397 N/A physical interaction ComPPI
CDC16 HECW2 25348397 N/A physical interaction ComPPI
CDC16 UBE2S 25348397 N/A physical interaction ComPPI
CDC16 MOV10 25348397 N/A physical interaction ComPPI
CDC16 NXF1 25348397 N/A physical interaction ComPPI
CDC16 BRCA1 25348397 N/A physical interaction ComPPI
CDC16 FZR1 20360068 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 MAGIX 25348397 N/A physical interaction ComPPI
CDC16 TTLL1 25348397 N/A physical interaction ComPPI
CDC16 TAF4 25348397 N/A physical interaction ComPPI
CDC16 TAF5 25348397 N/A physical interaction ComPPI
CDC16 NAP1L4 25348397 N/A physical interaction ComPPI
CDC16 TAF3 25348397 N/A physical interaction ComPPI
CDC16 ATP5PF 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 NEK2 20360068 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 PYCR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 PYCR2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 NSUN5 25348397 N/A physical interaction ComPPI
CDC16 ANAPC16 20360068 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC16 SMCR8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC16 USP37 25348397 N/A physical interaction ComPPI
CDC16 C16ORF87 25348397 N/A physical interaction ComPPI
CDC16 KIAA0586 25348397 N/A physical interaction ComPPI
CDC16 CEP295 25348397 N/A physical interaction ComPPI
CDC16 STIL 25348397 N/A physical interaction ComPPI
CDC16 KRBA1 25348397 N/A physical interaction ComPPI
CDC16 CEP350 25348397 N/A physical interaction ComPPI
CDC16 EIF4ENIF1 25348397 N/A physical interaction ComPPI
CDC16 ZNF318 25348397 N/A physical interaction ComPPI
CDC16 USP54 25348397 N/A physical interaction ComPPI
CDC16 IZUMO1 25348397 N/A physical interaction ComPPI
CDC16 CEP164 25348397 N/A physical interaction ComPPI
CDC16 ANO6 25348397 N/A physical interaction ComPPI
CDC16 YY1AP1 25348397 N/A physical interaction ComPPI
CDC16 ANKHD1 25348397 N/A physical interaction ComPPI
CDC16 SALL2 25348397 N/A physical interaction ComPPI
CDC16 TTC8 25348397 N/A physical interaction ComPPI
CDC16 KIF2B 25348397 N/A physical interaction ComPPI
CDC16 RECQL4 25348397 N/A physical interaction ComPPI
CDC16 MYO5C 25348397 N/A physical interaction ComPPI
CDC16 ALMS1 25348397 N/A physical interaction ComPPI
CDC16 HAUS8 25348397 N/A physical interaction ComPPI
CDC16 TRPS1 25348397 N/A physical interaction ComPPI
CDC16 DUS3L 25348397 N/A physical interaction ComPPI
CDC16 TEDC1 25348397 N/A physical interaction ComPPI
CDC16 TROAP 25348397 N/A physical interaction ComPPI
CDC16 ZNF644 25348397 N/A physical interaction ComPPI
CDC16 SMG8 25348397 N/A physical interaction ComPPI
CDC16 IQCB1 25348397 N/A physical interaction ComPPI
CDC16 BUB1 25348397 N/A physical interaction ComPPI
CDC16 SMG7 25348397 N/A physical interaction ComPPI
CDC16 C15ORF39 25348397 N/A physical interaction ComPPI
CDC16 GPR156 25348397 N/A physical interaction ComPPI
CDC16 RSBN1 25348397 N/A physical interaction ComPPI
CDC16 PLCH1 25348397 N/A physical interaction ComPPI
CDC16 LONP2 25348397 N/A physical interaction ComPPI
CDC16 RICTOR 25348397 N/A physical interaction ComPPI
CDC16 PIK3C2A 25348397 N/A physical interaction ComPPI
CDC16 CCP110 25348397 N/A physical interaction ComPPI
CDC16 NCOR1 25348397 N/A physical interaction ComPPI
CDC16 HAUS6 25348397 N/A physical interaction ComPPI
CDC16 ERF 25348397 N/A physical interaction ComPPI
CDC16 PHLDB3 25348397 N/A physical interaction ComPPI
CDC16 MYO9A 25348397 N/A physical interaction ComPPI
CDC16 BCOR 25348397 N/A physical interaction ComPPI
CDC16 DISC1 25348397 N/A physical interaction ComPPI
CDC16 HAUS3 25348397 N/A physical interaction ComPPI
CDC16 SNX18 25348397 N/A physical interaction ComPPI
CDC16 HOOK3 25348397 N/A physical interaction ComPPI
CDC16 KAT14 25348397 N/A physical interaction ComPPI
CDC16 RAVER1 25348397 N/A physical interaction ComPPI
CDC16 TRIM37 25348397 N/A physical interaction ComPPI
CDC16 ZNF687 25348397 N/A physical interaction ComPPI
CDC16 ASPM 25348397 N/A physical interaction ComPPI
CDC16 CEP97 25348397 N/A physical interaction ComPPI
CDC16 EIF4E2 25348397 N/A physical interaction ComPPI
CDC16 HAUS7 25348397 N/A physical interaction ComPPI
CDC16 TASOR 25348397 N/A physical interaction ComPPI
CDC16 ALOX5 25348397 N/A physical interaction ComPPI
CDC16 JMJD4 25348397 N/A physical interaction ComPPI
CDC16 FAM83H 25348397 N/A physical interaction ComPPI
CDC16 MGA 25348397 N/A physical interaction ComPPI
CDC16 HAUS5 25348397 N/A physical interaction ComPPI
CDC16 TRIM24 25348397 N/A physical interaction ComPPI
CDC16 ZNF281 25348397 N/A physical interaction ComPPI
CDC16 HOOK1 25348397 N/A physical interaction ComPPI
CDC16 MKS1 25348397 N/A physical interaction ComPPI
CDC16 GTSE1 25348397 N/A physical interaction ComPPI
CDC16 MAP7D3 25348397 N/A physical interaction ComPPI
CDC16 DHX35 25348397 N/A physical interaction ComPPI
CDC16 ZNHIT6 25348397 N/A physical interaction ComPPI
CDC16 YDJC 25348397 N/A physical interaction ComPPI
CDC16 SAMD1 25348397 N/A physical interaction ComPPI
CDC16 ESPL1 25348397 N/A physical interaction ComPPI
CDC16 TUBB8 25348397 N/A physical interaction ComPPI
CDC16 MED12 25348397 N/A physical interaction ComPPI
CDC16 MLF1 25348397 N/A physical interaction ComPPI
CDC16 ALG13 25348397 N/A physical interaction ComPPI
CDC16 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
CDC16 UHRF2 25348397 N/A physical interaction ComPPI
CDC16 ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
CDC16 CDK7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC16 CDK8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BUB3 CDC16 20360068 24234451 25348397 association tandem affinity purification ComPPI,IntAct
H3C1 CDC16 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC26 CDC16 20360068 21988832 24234451 25348397 25416956 26496610 association,physical association anti tag coimmunoprecipitation,circular dichroism,two hybrid,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ANAPC13 CDC16 20360068 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CDK1 CDC16 10871279 14657031 23751495 27898060 stimulant N/A OmniPath

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