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GENE：CDC27

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDC27
FullNmae cell division cycle 27
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1728
EnsembleID ENSG00000004897
Uniprot P30260

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDC27 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC27 ferroptosis 35242701 Collectively, our data is the first to report that the CDC27/ODC1 axis promotes tumorigenesis and acts as a positive regulator of ferroptosis in NB, highlighting that CDC27 may represent a novel therapeutic strategy and prognostic biomarker in neuroblastoma. retulator signature
CDC27 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CDC27 GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005680,GO:0005680,GO:0005680,GO:0005680,GO:0005737,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0007091,GO:0007091,GO:0007346,GO:0016567,GO:0019903,GO:0031145,GO:0031145,GO:0051301,GO:0051445,GO:0070979,GO:0072686

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDC27 hsa:996 path:hsa04110 Cell cycle - Homo sapiens (human)
CDC27 hsa:996 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
CDC27 hsa:996 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
CDC27 hsa:996 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
CDC27 hsa:996 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIN1 CDC27 10037602 23180781 9499405 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
AR CDC27 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CDC27 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CDC27 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CDC27 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CDC27 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A CDC27 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 CDC27 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CDC27 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 CDC27 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CDC27 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002FC5B0 CDC27 20371350 22473208 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000B7E30 CDC27 24324762 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000039607D CDC27 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00002AAD6B CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000544FF1 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000035925E CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CDC27 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 CDC27 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B CDC27 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002AA55A CDC27 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA CDC27 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 CDC27 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D CDC27 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C CDC27 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CDC27 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001F9A0F CDC27 25416803 27974673 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001B341F CDC27 25416803 25943633 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 CDC27 22135298 phosphorylation N/A PhosphoSite
PRKAA2 CDC27 22135298 phosphorylation N/A PhosphoSite
CDK1 CDC27 22135298 phosphorylation N/A PhosphoSite
PLK1 CDC27 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 CDC27 10037602 14525934 25348397 9499405 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ZNF408 CDC27 25348397 N/A physical interaction ComPPI
SNW1 CDC27 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L CDC27 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CKS1B CDC27 25348397 N/A physical interaction ComPPI
MAD2L2 CDC27 17719540 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SH3KBP1 CDC27 25348397 N/A physical interaction ComPPI
PCNA CDC27 25348397 N/A physical interaction ComPPI
CDKN1A CDC27 25348397 N/A physical interaction ComPPI
SKIL CDC27 11691834 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CCND1 CDC27 20439707 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 CDC27 25348397 N/A physical interaction ComPPI
VCP CDC27 25348397 N/A physical interaction ComPPI
HHEX CDC27 25348397 N/A physical interaction ComPPI
TACC3 CDC27 25348397 N/A physical interaction ComPPI
PIK3R1 CDC27 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRAP2 CDC27 25348397 N/A physical interaction ComPPI
NOTCH1 CDC27 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NCK1 CDC27 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CASP3 CDC27 14525934 25348397 9618490 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB2 CDC27 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
RB1 CDC27 14525934 17187060 25348397 27898060 7756179 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CREBBP CDC27 25348397 N/A physical interaction ComPPI
SMAD2 CDC27 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 CDC27 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDC16 CDC27 14525934 16648845 20360068 24234451 25348397 26496610 9405394 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,tandem affinity purification,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct
FZR1 CDC27 12797865 14525934 18662541 21186364 21241890 22014574 24234451 25348397 9637688 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PAXIP1 CDC27 25348397 N/A physical interaction ComPPI
NTRK1 CDC27 25348397 N/A physical interaction ComPPI
CDH1 CDC27 20802534 20951947 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,immunodepleted coimmunoprecipitation ComPPI,IntAct
BUB3 CDC27 25348397 N/A physical interaction ComPPI
PPP2R5A CDC27 25348397 N/A physical interaction ComPPI
E2F1 CDC27 25348397 N/A physical interaction ComPPI
NEK2 CDC27 16648845 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2CA CDC27 25348397 N/A physical interaction ComPPI
ELMO1 CDC27 25348397 N/A physical interaction ComPPI
ELMO2 CDC27 25348397 N/A physical interaction ComPPI
ANAPC10 CDC27 11524682 14525934 24234451 25348397 26496610 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
NUP98 CDC27 25348397 N/A physical interaction ComPPI
XPO1 CDC27 25348397 N/A physical interaction ComPPI
RRM2 CDC27 25348397 N/A physical interaction ComPPI
EPN3 CDC27 25348397 N/A physical interaction ComPPI
CDC20 CDC27 12196507 14525934 14561775 17443180 17443186 20212161 20360068 20951947 22014574 24234451 24781523 25348397 9637688 9736712 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
TFDP1 CDC27 25348397 N/A physical interaction ComPPI
TAF4 CDC27 25348397 N/A physical interaction ComPPI
FBXO5 CDC27 17719540 18662541 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TAF5 CDC27 25348397 N/A physical interaction ComPPI
CDK7 CDC27 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CCNB1 CDC27 25348397 N/A physical interaction ComPPI
CTNNB1 CDC27 25348397 N/A physical interaction ComPPI
SIRT2 CDC27 22014574 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PTEN CDC27 21241890 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
MDC1 CDC27 17827148 19826003 22942284 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FDPS CDC27 25348397 N/A physical interaction ComPPI
USP11 CDC27 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FYN CDC27 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
H3C1 CDC27 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BUB1B CDC27 10477750 11030144 14525934 20212161 20360068 20951947 21300909 24234451 25348397 25852190 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
RPL5 CDC27 25348397 N/A physical interaction ComPPI
FOXE1 CDC27 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
UBE4B CDC27 25348397 N/A physical interaction ComPPI
PPP5C CDC27 14525934 25348397 9405394 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MIB1 CDC27 25348397 N/A physical interaction ComPPI
FOXO3 CDC27 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
CCNA2 CDC27 25348397 N/A physical interaction ComPPI
MAD2L1 CDC27 14525934 17443180 17443186 20212161 20951947 21772247 24234451 25348397 26496610 9736712 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MAD2L1BP CDC27 25348397 N/A physical interaction ComPPI
KIF2B CDC27 25348397 N/A physical interaction ComPPI
TEAD2 CDC27 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HECW2 CDC27 25348397 N/A physical interaction ComPPI
BIRC6 CDC27 25348397 N/A physical interaction ComPPI
REV1 CDC27 25348397 N/A physical interaction ComPPI
MAD1L1 CDC27 25348397 N/A physical interaction ComPPI
AURKB CDC27 25348397 N/A physical interaction ComPPI
TRIM33 CDC27 25348397 N/A physical interaction ComPPI
TTK CDC27 12686615 20729194 22045814 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ANAPC5 CDC27 20360068 21241890 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ANAPC2 CDC27 10922056 14525934 16648845 17443186 20360068 24234451 25043029 25348397 26083744 27120157 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,electron tomography,in vivo ComPPI,HPRD,IntAct
ANAPC11 CDC27 25348397 N/A physical interaction ComPPI
COMT CDC27 25348397 N/A physical interaction ComPPI
CDC27 HOXC10 12853486 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CDC27 ANAPC1 20360068 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 ANAPC4 20360068 21241890 24234451 25348397 25383541 26083744 26496610 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CDC27 ANAPC7 10922056 14525934 21241890 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,inference by socio-affinity scoring ComPPI,HPRD,IntAct
CDC27 CDC23 16648845 20360068 24234451 25348397 26496610 27173435 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CDC27 PTTG1 21186364 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC27 PTTG2 25348397 N/A physical interaction ComPPI
CDC27 HSF2 25348397 N/A physical interaction ComPPI
CDC27 UBE2S 25348397 N/A physical interaction ComPPI
CDC27 ANAPC16 20360068 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 SMARCAD1 25348397 N/A physical interaction ComPPI
CDC27 CUEDC2 25348397 N/A physical interaction ComPPI
CDC27 NINL 25348397 N/A physical interaction ComPPI
CDC27 FOXM1 25348397 N/A physical interaction ComPPI
CDC27 USP37 25348397 N/A physical interaction ComPPI
CDC27 EMILIN1 25348397 N/A physical interaction ComPPI
CDC27 MCPH1 22139841 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDC27 ANAPC15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC27 GKN1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC27 DCPS 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC27 ADNP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC27 PHF8 25348397 N/A physical interaction ComPPI
CDC27 FBXO43 17276914 20534816 24770399 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDC27 SIRT6 25348397 N/A physical interaction ComPPI
CDC27 PENK 25348397 N/A physical interaction ComPPI
CDC27 MAGIX 25348397 N/A physical interaction ComPPI
CDC27 TTLL1 25348397 N/A physical interaction ComPPI
CDC27 DCLRE1C 25348397 N/A physical interaction ComPPI
CDC27 NCL 25348397 N/A physical interaction ComPPI
CDC27 CFAP97 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC27 CHD8 25348397 N/A physical interaction ComPPI
CDC27 ZNF526 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC27 RBPJ 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CDC27 C16ORF87 25348397 N/A physical interaction ComPPI
CDC27 ANO6 25348397 N/A physical interaction ComPPI
CDC27 RNF19B 25348397 N/A physical interaction ComPPI
CDC27 SRP68 25348397 N/A physical interaction ComPPI
CDC27 RSBN1 25348397 N/A physical interaction ComPPI
CDC27 HOXD13 25348397 N/A physical interaction ComPPI
CDC27 LNP1 25348397 N/A physical interaction ComPPI
CDC27 CDCA5 21186364 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC27 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CDC26 CDC27 10922056 14525934 20360068 24234451 25348397 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
ANAPC13 CDC27 20360068 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H1-1 CDC27 24234451 30021884 physical association cross-linking study IntAct
CDC27 CCDC125 24234451 30021884 physical association cross-linking study IntAct
PIN1 CDC27 10037602 27898060 9499405 N/A N/A OmniPath
CDK1 CDC27 10871279 14657031 23751495 27898060 stimulant N/A OmniPath
CSNK2A1 CDC27 21209074 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C2FFC CDC27 27087310 direct interaction,inhibition N/A NPInter

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