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GENE：CERS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CERS2
FullNmae ceramide synthase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14076
EnsembleID ENSG00000143418
Uniprot Q96G23

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CERS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CERS2 GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0016020,GO:0019216,GO:0030148,GO:0035902,GO:0046513,GO:0046513,GO:0048681,GO:0050291,GO:0050291,GO:0050291,GO:1900148,GO:1905045

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CERS2 hsa:29956 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
CERS2 hsa:29956 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CERS2 hsa:29956 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CERS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CERS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CERS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CERS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF6 CERS2 22169644 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CERS2 22169644 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CERS2 22169644 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 CERS2 22393241 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000153377 CERS2 22393241 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 CERS2 22393241 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000153377 CERS2 22393241 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 CERS2 20371350 25416803 27099514 mrna cleavage,inhibition nucleotide sequence identification,western blot TarBase
URS0000001A7A CERS2 23622248 25416803 26701625 27292025 mrna cleavage,inhibition clip,clash TarBase
URS0000042E1F CERS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004ACAAA CERS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 CERS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA CERS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 CERS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000034B6F5 CERS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000054DF42 CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005E58C CERS2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 CERS2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 CERS2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC0F4 CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C CERS2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E96DA CERS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000017CCCB CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002198F3 CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000023133F CERS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000020579D CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000015A0D9 CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000047A8F CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000214763 CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000235862 CERS2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000079F78 CERS2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATP5F1B CERS2 25348397 N/A physical interaction ComPPI
PSMD14 CERS2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ATP6V0C CERS2 11543633 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
KPNB1 CERS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA1 CERS2 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
PTPN5 CERS2 24234451 25348397 28330616 association pull down ComPPI,IntAct
ATP6AP2 CERS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR CERS2 25348397 N/A physical interaction ComPPI
NDN CERS2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FUBP1 CERS2 25348397 N/A physical interaction ComPPI
PTPRE CERS2 25348397 N/A physical interaction ComPPI
CERS2 SLC22A1 11543633 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CERS2 ASGR1 11543633 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
CERS2 FLOT1 25348397 N/A physical interaction ComPPI
CERS2 ELOVL1 25348397 N/A physical interaction ComPPI
CERS2 TECR 25348397 N/A physical interaction ComPPI
CERS2 HSD17B12 25348397 N/A physical interaction ComPPI
CERS2 ELOVL5 25348397 N/A physical interaction ComPPI
CERS2 PEX6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CERS2 TMBIM6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CERS2 ATP5PB 25348397 N/A physical interaction ComPPI
CERS2 LPAR1 25348397 N/A physical interaction ComPPI
CERS2 VIPR2 25348397 N/A physical interaction ComPPI
CERS2 HTR2C 25348397 N/A physical interaction ComPPI
CERS2 TACR1 25348397 N/A physical interaction ComPPI
CERS2 C3AR1 25348397 N/A physical interaction ComPPI
CERS2 RELL1 25348397 N/A physical interaction ComPPI
CERS2 TRIM25 25348397 N/A physical interaction ComPPI
CERS2 ARHGEF7 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
KIF1B CERS2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CERS2 DRD2 24234451 28298427 physical association ubiquitin reconstruction IntAct

Source Target Pmid Interactiontype Methods Database
URS00009BC133 CERS2 27087310 direct interaction,inhibition N/A NPInter

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