Gene Information gene info

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GENE：CHTOP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CHTOP
FullNmae chromatin target of PRMT1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24511
EnsembleID ENSG00000160679
Uniprot Q9Y3Y2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CHTOP autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHTOP cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CHTOP GO:0000346,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0006406,GO:0006406,GO:0008327,GO:0016607,GO:0016607,GO:0032781,GO:0051096

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 CHTOP 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 CHTOP 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 CHTOP 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR CHTOP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CHTOP 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CHTOP 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CHTOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CHTOP 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001C3AC1 CHTOP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 CHTOP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 CHTOP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 CHTOP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004C5774 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB35 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 CHTOP 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 CHTOP 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GABARAPL2 CHTOP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BMI1 CHTOP 25348397 N/A physical interaction ComPPI
KEAP1 CHTOP 25348397 N/A physical interaction ComPPI
SMN1 CHTOP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KHDRBS2 CHTOP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
JUN CHTOP 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
U2AF2 CHTOP 25348397 N/A physical interaction ComPPI
PRMT1 CHTOP 19858291 24234451 25284789 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
CANX CHTOP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRMT5 CHTOP 25348397 N/A physical interaction ComPPI
DCTN1 CHTOP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
THOC5 CHTOP 23299939 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPHP1 CHTOP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VDAC1 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
THOC1 CHTOP 23299939 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRSF2 CHTOP 23299939 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
SRPK1 CHTOP 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR77 CHTOP 25348397 N/A physical interaction ComPPI
SFN CHTOP 25348397 N/A physical interaction ComPPI
RNF2 CHTOP 25348397 N/A physical interaction ComPPI
MAP1LC3A CHTOP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 CHTOP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NXT1 CHTOP 23299939 24234451 25348397 association,physical association pull down ComPPI,IntAct
BCLAF1 CHTOP 25348397 N/A physical interaction ComPPI
LBR CHTOP 25348397 N/A physical interaction ComPPI
ELAVL1 CHTOP 25348397 N/A physical interaction ComPPI
SRPK2 CHTOP 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
TNFRSF13B CHTOP 25348397 N/A physical interaction ComPPI
PARK7 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HECW2 CHTOP 25348397 N/A physical interaction ComPPI
MAGOH CHTOP 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ALYREF CHTOP 23299939 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
AURKAIP1 CHTOP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ERH CHTOP 24234451 25348397 25416956 30021884 physical association cross-linking study,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EIF4A3 CHTOP 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRPK3 CHTOP 23602568 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SUZ12 CHTOP 25348397 N/A physical interaction ComPPI
THOC7 CHTOP 25348397 N/A physical interaction ComPPI
ATG12 CHTOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SARNP CHTOP 25348397 N/A physical interaction ComPPI
DLST CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FYTTD1 CHTOP 25348397 N/A physical interaction ComPPI
HSD17B10 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DDX39B CHTOP 14667819 23299939 24234451 25348397 30021884 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cross-linking study,pull down ComPPI,IntAct
HSF2 CHTOP 25348397 N/A physical interaction ComPPI
PRMT8 CHTOP 25348397 N/A physical interaction ComPPI
SCLT1 CHTOP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
APP CHTOP 25348397 N/A physical interaction ComPPI
NXF1 CHTOP 23299939 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MOV10 CHTOP 25348397 N/A physical interaction ComPPI
ZC3H18 CHTOP 24234451 25348397 29298432 association anti tag coimmunoprecipitation ComPPI,IntAct
OBSL1 CHTOP 25348397 N/A physical interaction ComPPI
COX15 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CEP290 CHTOP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CCDC8 CHTOP 25348397 N/A physical interaction ComPPI
CHTOP LUZP4 25348397 N/A physical interaction ComPPI
CHTOP RSPO1 25348397 N/A physical interaction ComPPI
CHTOP RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CHTOP POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CHTOP THOC2 23299939 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHTOP CHCHD10 25348397 N/A physical interaction ComPPI
CHTOP SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CHTOP MTIF2 24234451 30021884 physical association cross-linking study IntAct
CHTOP DDX39A 24234451 30021884 physical association cross-linking study IntAct
CHTOP ZNF585A 24234451 30021884 physical association cross-linking study IntAct
CHTOP CENPC 24234451 30021884 physical association cross-linking study IntAct
L1TD1 CHTOP 24234451 25702638 association anti bait coimmunoprecipitation IntAct

Visualization










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