Gene Information gene info

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GENE：CIAO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CIAO1
FullNmae cytosolic iron-sulfur assembly component 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14280
EnsembleID ENSG00000144021
Uniprot O76071

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CIAO1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CIAO1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CIAO1 cuproptosis 36313717 Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) Proteins carrying iron-sulfur cluster
CIAO1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins
CIAO1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CIAO1 GO:0005515,GO:0005737,GO:0006357,GO:0007059,GO:0008284,GO:0016226,GO:0016226,GO:0016226,GO:0071817,GO:0097361,GO:0097361,GO:0097428

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SRPK1 CIAO1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CIAO1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF CIAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CIAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
WT1 CIAO1 9556563 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 CIAO1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000338542 CIAO1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 CIAO1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AA464 CIAO1 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000075AB14 CIAO1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 CIAO1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E CIAO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 CIAO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F CIAO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 CIAO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD CIAO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C CIAO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 CIAO1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 CIAO1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 CIAO1 19536157 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 CIAO1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED CIAO1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB CIAO1 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00001CC4BD CIAO1 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS000075B538 CIAO1 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MMS19 CIAO1 25361965 interaction type N/A PTMCode2
CIAO1 MMS19 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC73 CIAO1 25348397 N/A physical interaction ComPPI
CIAO1 CIAO2B 14525934 16189514 21516116 24234451 25348397 25416956 28178521 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CIAO1 WT1 14525934 25348397 9556563 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CIAO1 CIAO2A 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CIAO1 CCDC7 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CIAO1 GOLM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CIAO1 GAS8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 MLF2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 MCM5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 USP11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 DNAAF5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 MYO1C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 WDR5 25348397 N/A physical interaction ComPPI
CIAO1 APP 25348397 N/A physical interaction ComPPI
CIAO1 MMS19 17353931 21516116 24234451 25348397 28178521 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CIAO1 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CIAO1 CHD1L 25348397 N/A physical interaction ComPPI
CIAO1 ERCC2 24234451 25348397 28178521 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 IREB2 25348397 N/A physical interaction ComPPI
CIAO1 PHAX 25348397 N/A physical interaction ComPPI
CIAO1 UPF3B 25348397 N/A physical interaction ComPPI
CIAO1 WDR75 25348397 N/A physical interaction ComPPI
CIAO1 DPP8 25348397 N/A physical interaction ComPPI
CIAO1 DPP9 25348397 N/A physical interaction ComPPI
CIAO1 POLA2 25348397 N/A physical interaction ComPPI
CIAO1 POLE 25348397 N/A physical interaction ComPPI
CIAO1 TYW1 25348397 N/A physical interaction ComPPI
CIAO1 YAE1 25348397 N/A physical interaction ComPPI
CIAO1 TOE1 25348397 N/A physical interaction ComPPI
CIAO1 LEO1 25348397 N/A physical interaction ComPPI
CIAO1 WDR43 25348397 N/A physical interaction ComPPI
CIAO1 NUP35 25348397 N/A physical interaction ComPPI
CIAO1 ELP2 25348397 N/A physical interaction ComPPI
CIAO1 GLRX3 25348397 N/A physical interaction ComPPI
CIAO1 MRE11 25348397 N/A physical interaction ComPPI
CIAO1 PLEKHA5 25348397 N/A physical interaction ComPPI
CIAO1 PPAT 25348397 N/A physical interaction ComPPI
CIAO1 UCKL1 25348397 N/A physical interaction ComPPI
CIAO1 TSC2 25348397 N/A physical interaction ComPPI
CIAO1 MAK16 25348397 N/A physical interaction ComPPI
CIAO1 ERP29 25348397 N/A physical interaction ComPPI
CIAO1 RTEL1 25348397 N/A physical interaction ComPPI
CIAO1 CNP 25348397 N/A physical interaction ComPPI
CIAO1 ABCE1 25348397 N/A physical interaction ComPPI
CIAO1 TSC1 25348397 N/A physical interaction ComPPI
CIAO1 PPIL4 25348397 N/A physical interaction ComPPI
CIAO1 WDR61 25348397 N/A physical interaction ComPPI
CIAO1 ELP3 25348397 N/A physical interaction ComPPI
CIAO1 POLA1 25348397 N/A physical interaction ComPPI
CIAO1 PAF1 25348397 N/A physical interaction ComPPI
CIAO1 EEPD1 25348397 N/A physical interaction ComPPI
CIAO1 ELP5 25348397 N/A physical interaction ComPPI
CIAO1 ELP6 25348397 N/A physical interaction ComPPI
CIAO1 CTU2 25348397 N/A physical interaction ComPPI
CIAO1 NSRP1 25348397 N/A physical interaction ComPPI
CIAO1 CDKAL1 25348397 N/A physical interaction ComPPI
CIAO1 SF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CIAO1 CTR9 25348397 N/A physical interaction ComPPI
CIAO1 FMNL3 25348397 N/A physical interaction ComPPI
CIAO1 ELP4 25348397 N/A physical interaction ComPPI
CIAO1 FMNL2 25348397 N/A physical interaction ComPPI
CIAO1 POLD1 24234451 25348397 28178521 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 CIAO3 25348397 N/A physical interaction ComPPI
CIAO1 CTU1 25348397 N/A physical interaction ComPPI
CIAO1 UGDH 25348397 N/A physical interaction ComPPI
CIAO1 PRIM1 25348397 N/A physical interaction ComPPI
CIAO1 PRIM2 25348397 N/A physical interaction ComPPI
CIAO1 DNA2 25348397 N/A physical interaction ComPPI
CIAO1 GOLGA3 25348397 N/A physical interaction ComPPI
CIAO1 MEOX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CIAO1 MPPED1 25348397 N/A physical interaction ComPPI
CIAO1 SLC30A4 25348397 N/A physical interaction ComPPI
CIAO1 WBP1 25348397 N/A physical interaction ComPPI
CIAO1 RSAD2 24234451 24245804 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 MTM1 25348397 N/A physical interaction ComPPI
CIAO1 CPLX3 25348397 N/A physical interaction ComPPI
CIAO1 FBXL5 25348397 N/A physical interaction ComPPI
CIAO1 RGS13 25348397 N/A physical interaction ComPPI
CIAO1 AKAP8L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 NDUFA9 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 RPAP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 MRPL24 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 HELLS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 GTF3C5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 GNL3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 MCM3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 FBL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 CDK2AP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 RO60 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 COPB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 GTF3C3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 POLR1C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 HDAC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 NUBP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 DDX20 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 PSMB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 DPM1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 SNRNP200 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 CLPX 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 TRIM28 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 MYO1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 TUBG2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 EIF4G2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 KATNA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 HLTF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 SLFN11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 BAG6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 MYO1D 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 CDC45 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 ACACA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 DCTN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 NUP93 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 HSPB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 IPO4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 IFT88 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
CIAO1 HAUS3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 RGS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 PGRMC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 TOP3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 TCP10L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 SLC4A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CIAO1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct

Visualization










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