GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
CIAO2A
FullNmae
cytosolic iron-sulfur assembly component 2A
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:26235
EnsembleID
ENSG00000166797
Uniprot
Q9H5X1
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
CIAO2A
cuproptosis
36313717
The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1.
Genes of iron-sulfur cluster related proteins
CIAO2A
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
CIAO2A
GO:0005515,GO:0005654,GO:0005829,GO:0007059,GO:0016226,GO:0046872,GO:0097361,GO:0097428,GO:0106035
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
CIAO2A
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
ETS1
CIAO2A
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
SMARCA4
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F1
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F4
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
CIAO2A
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS0000324096
CIAO2A
N/A
rna interference,inhibition
experimental interaction detection
miRSponge
URS0000324096
CIAO2A
18668040
25416803
mrna cleavage,inhibition
experimental interaction detection,experimental interaction detection,experimental interaction detection
TarBase
URS00000ED600
CIAO2A
20215506
25416803
mrna cleavage,inhibition
array technology
TarBase
URS0000065D58
CIAO2A
18668040
25416803
mrna cleavage,inhibition
experimental interaction detection
TarBase
URS00001CC4BD
CIAO2A
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000033EBB8
CIAO2A
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000236310
CIAO2A
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000018C928
CIAO2A
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000272039
CIAO2A
23313552
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000040EC3B
CIAO2A
23313552
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000259AE4
CIAO2A
23313552
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000100748
CIAO2A
23313552
25416803
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
CIAO1
CIAO2A
14525934
16189514
24234451
25348397
25416956
physical association
two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid
ComPPI,HPRD,IntAct
APOA2
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
POLE
CIAO2A
25348397
N/A
physical interaction
ComPPI
AGTRAP
CIAO2A
25348397
N/A
physical interaction
ComPPI
TOP3B
CIAO2A
25348397
N/A
physical interaction
ComPPI
VAMP3
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
PLP2
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
PRPS2
CIAO2A
25348397
N/A
physical interaction
ComPPI
DERL1
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
DNAJB6
CIAO2A
25348397
N/A
physical interaction
ComPPI
TNFRSF10D
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
EBAG9
CIAO2A
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
CIAO2A
IREB2
25348397
N/A
physical interaction
ComPPI
CIAO2A
MLF2
25348397
N/A
physical interaction
ComPPI
CIAO2A
LIME1
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
CIAO2A
PRAF2
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
CIAO2A
CREB3L1
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
Visualization