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GENE：CLPP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLPP
FullNmae caseinolytic mitochondrial matrix peptidase proteolytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2084
EnsembleID ENSG00000125656
Uniprot Q16740

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLPP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLPP cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CLPP GO:0004175,GO:0004176,GO:0004252,GO:0004252,GO:0005515,GO:0005739,GO:0005759,GO:0005759,GO:0006508,GO:0006515,GO:0008233,GO:0009368,GO:0009368,GO:0009368,GO:0033619,GO:0042802,GO:0051117,GO:0051603

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CLPP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CLPP 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CLPP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F4 CLPP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLPP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 CLPP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005CE28 CLPP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE CLPP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B CLPP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A CLPP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 CLPP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 CLPP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 CLPP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D CLPP 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CLPP CLPX 25361965 interaction type N/A PTMCode2
CLPX CLPP 25361965 interaction type N/A PTMCode2
CLPP TUFM 25361965 interaction type N/A PTMCode2
TUFM CLPP 25361965 interaction type N/A PTMCode2
CLPP HSPD1 25361965 interaction type N/A PTMCode2
HSPD1 CLPP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RBPMS CLPP 25348397 N/A two hybrid ComPPI
SAP18 CLPP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COX5B CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
EFEMP2 CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NUTF2 CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FBXO17 CLPP 25348397 N/A physical interaction ComPPI
KEAP1 CLPP 25348397 N/A physical interaction ComPPI
COX5A CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
SMN1 CLPP 25348397 N/A two hybrid ComPPI
SSBP1 CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
POLDIP2 CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
PPP2CA CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FECH CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
TRAP1 CLPP 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
TST CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
MT-ND1 CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
EGFR CLPP 25348397 N/A physical interaction ComPPI
DTX2 CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EFEMP1 CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FDPS CLPP 25348397 N/A physical interaction ComPPI
IDH3B CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 CLPP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK3 CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
TFAM CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
BIRC5 CLPP 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SARS2 CLPP 25348397 N/A physical interaction ComPPI
ECSIT CLPP 25348397 N/A physical interaction ComPPI
CLPX CLPP 11923310 14525934 24234451 25348397 26058080 27898060 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct,OmniPath
CLPP FBXW11 25348397 N/A physical interaction ComPPI
CLPP PPA2 25348397 N/A physical interaction ComPPI
CLPP NDUFA10 25348397 N/A physical interaction ComPPI
CLPP MRPS30 25348397 N/A physical interaction ComPPI
CLPP ARNTL2 25348397 N/A physical interaction ComPPI
CLPP USP47 25348397 N/A physical interaction ComPPI
CLPP MTG2 25348397 N/A physical interaction ComPPI
CLPP YBEY 25348397 N/A physical interaction ComPPI
CLPP UQCC1 25348397 N/A physical interaction ComPPI
CLPP MRPL12 25348397 N/A physical interaction ComPPI
CLPP SLC25A10 25348397 N/A physical interaction ComPPI
CLPP ARNT2 25348397 N/A physical interaction ComPPI
CLPP FOXRED1 25348397 N/A physical interaction ComPPI
CLPP ZNF133 25348397 N/A physical interaction ComPPI
CLPP IMPDH1 25348397 N/A physical interaction ComPPI
CLPP SDHB 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CLPP HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLPP RAB5IF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLPP GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLPP ACO2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP MRRF 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ATP5MK 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP NDUFAF1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP GLUD2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP POLG2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP COQ3 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP COX7C 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP MTRF1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP GCDH 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP COX6A1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP UQCR10 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ALAS1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP CBR4 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP NDUFA4 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP TMLHE 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP CDS2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP SDHC 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP HSD17B4 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP FDX1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP MT-ATP8 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP PMPCB 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ACSS1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ACADM 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP NARS2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP GSTK1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP OXCT1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP AK3 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP AK4 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ACADSB 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP WARS2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP NIPSNAP1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP QRSL1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP ALDH4A1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP NFS1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP SDHA 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP CARS2 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP CS 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CLPP C14ORF119 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLPP PLSCR4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLPP P4HA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLPP AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PSMB1 CLPP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AURKAIP1 CLPP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 CLPP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNRNP27 CLPP 25348397 N/A physical interaction ComPPI
TRIM43 CLPP 25348397 N/A physical interaction ComPPI
TRMT61B CLPP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP CLPP 14525934 16115876 20637416 24234451 N/A cosedimentation in solution,experimental interaction detection HPRD,IntAct

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