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GENE：CLPX

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLPX
FullNmae caseinolytic mitochondrial matrix peptidase chaperone subunit X
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2088
EnsembleID ENSG00000166855
Uniprot O76031

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLPX cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CLPX GO:0004176,GO:0005515,GO:0005524,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0005759,GO:0005759,GO:0005829,GO:0006457,GO:0006508,GO:0008270,GO:0009368,GO:0009368,GO:0009841,GO:0016504,GO:0016887,GO:0016887,GO:0042645,GO:0046034,GO:0046983,GO:0051082,GO:0051603,GO:0051603,GO:0140662

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CLPX UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CLPX 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CLPX 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CLPX 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CLPX 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CLPX 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CLPX 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 CLPX 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000214763 CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075A281 CLPX 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 CLPX 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FBXW11 CLPX 25361965 interaction type N/A PTMCode2
CLPX FBXW11 25361965 interaction type N/A PTMCode2
CLPP CLPX 25361965 interaction type N/A PTMCode2
CLPX CLPP 25361965 interaction type N/A PTMCode2
CLPX BTRC 25361965 interaction type N/A PTMCode2
BTRC CLPX 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD2 CLPX 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 CLPX 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BOLA1 CLPX 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ATPAF2 CLPX 25348397 N/A physical interaction ComPPI
TOMM22 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FASTKD3 CLPX 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
LMNA CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
KEAP1 CLPX 25348397 N/A physical interaction ComPPI
MCM2 CLPX 25348397 N/A physical interaction ComPPI
GRB2 CLPX 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NTRK1 CLPX 25348397 N/A physical interaction ComPPI
NIT1 CLPX 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BTRC CLPX 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLDIP2 CLPX 25348397 N/A physical interaction ComPPI
C1QBP CLPX 25348397 N/A physical interaction ComPPI
MAPK6 CLPX 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PDP2 CLPX 25348397 N/A physical interaction ComPPI
CUL4B CLPX 25348397 N/A physical interaction ComPPI
CUL1 CLPX 25348397 N/A physical interaction ComPPI
EGFR CLPX 25348397 N/A physical interaction ComPPI
FASLG CLPX 25348397 N/A physical interaction ComPPI
RNF2 CLPX 25348397 N/A physical interaction ComPPI
LIG3 CLPX 25348397 N/A physical interaction ComPPI
RAB9A CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKN CLPX 25348397 N/A physical interaction ComPPI
H3C1 CLPX 24234451 25348397 29568061 association pull down ComPPI,IntAct
PDK1 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSPE1 CLPX 25348397 N/A physical interaction ComPPI
CLPX CLPP 11923310 14525934 24234451 25348397 26058080 27898060 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct,OmniPath
CLPX RAB5IF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPX FBXW11 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPX BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPX MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPX FBXO6 25348397 N/A physical interaction ComPPI
CLPX THTPA 25348397 N/A physical interaction ComPPI
CLPX ETFBKMT 25348397 N/A physical interaction ComPPI
CLPX AGMAT 25348397 N/A physical interaction ComPPI
CLPX GCAT 25348397 N/A physical interaction ComPPI
CLPX KIF12 25348397 N/A physical interaction ComPPI
CLPX OXLD1 25348397 N/A physical interaction ComPPI
CLPX LONP1 25348397 N/A physical interaction ComPPI
CLPX CHCHD10 25348397 N/A physical interaction ComPPI
CLPX PTPMT1 25348397 N/A physical interaction ComPPI
CLPX COQ9 25348397 N/A physical interaction ComPPI
CLPX CISD3 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPX NDUFS3 25348397 N/A physical interaction ComPPI
CLPX TRUB2 25348397 N/A physical interaction ComPPI
CLPX FMC1 25348397 N/A physical interaction ComPPI
CLPX COQ5 25348397 N/A physical interaction ComPPI
CLPX ATP5F1A 25348397 N/A physical interaction ComPPI
CLPX NDEL1 25348397 N/A physical interaction ComPPI
CLPX FOXRED1 25348397 N/A physical interaction ComPPI
CLPX GNS 25348397 N/A physical interaction ComPPI
CLPX CLEC3A 25348397 N/A physical interaction ComPPI
CLPX TRMT1 25348397 N/A physical interaction ComPPI
CLPX SDHB 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
CLPX EXD2 25348397 N/A physical interaction ComPPI
CLPX TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLPX PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLPX SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX AIFM1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
CLPX BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPX HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPX COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPX SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPX FBL 24234451 25348397 29568061 association pull down ComPPI,IntAct
CLPX MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX MIX23 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX RCC1L 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPX COQ6 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
AURKAIP1 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRIM43 CLPX 25348397 N/A physical interaction ComPPI
TRMT61B CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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