GENE：COA6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COA6 |
| FullNmae | cytochrome c oxidase assembly factor 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18025 |
| EnsembleID | ENSG00000168275 |
| Uniprot | Q5JTJ3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COA6 | cuproptosis | 36882769 | Copper ions entering the cytoplasm and mitochondrial intermembrane space bind to GSH and MT or form copper-containing molecular chaperones such as SOD1 which is crucial for proper function of copper. To sustain normal cellular functions, COA6, SCO1 and SCO2 work together to mediate the transfer of copper to COX in the mitochondrial intermembrane space. | copper transport |
| COA6 | cuproptosis | 36882769 | Cytochrome c oxidase assembly factor 6(COA6) served as a thiol-disulfide oxidoreductase to reduce the formation of disulfide bonds between cysteine residues in synthesis of cytochrome c oxidase1/2 (SCO1/2) and substances other than copper, thus allowing copper binding. The deficiency of COA6 lead to disorder of respiratory complex IV biogenesis. | regulator |
| COA6 | cuproptosis | 38006800 | As for CRG, 19 CRGs(CP,CD274,PDE3B,DLAT,VEGFA,DBH,COX11,COA6,PDK1,SLC31A2,UBE2D1,UlK1,SLC25A3,MTF1,UBE2D3,SLC31A1,MAP2K1,AOC3,CCL8) were significantly differentially expressed in the Control and sepsis induced cardiotoxicity groups in GSE44363 | cuproptosis-related genes |
| COA6 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| COA6 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| COA6 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
| COA6 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| COA6 | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COA6 | GO:0003723,GO:0005507,GO:0005515,GO:0005654,GO:0005739,GO:0005739,GO:0005739,GO:0005758,GO:0005886,GO:0008535,GO:0008535,GO:0008535,GO:0042774,GO:0042775,GO:0042775,GO:0045277 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| COA6 | hsa:388753 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | COA6 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | COA6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | COA6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | COA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | COA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | COA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | COA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD81 | COA6 | 24234451 25348397 26212323 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| GABARAP | COA6 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| DTX2 | COA6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| AIFM1 | COA6 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| COX4I1 | COA6 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MT-CO2 | COA6 | 25348397 | N/A | physical interaction | ComPPI |
| SFXN1 | COA6 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| COA6 | SCO2 | 25348397 | N/A | physical interaction | ComPPI |
| COA6 | SCO1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |